Variant · Expression
KRAS KRAS4A underexpression
CI-VAR-00002190Explore in graph →CIViC 3471
Curated evidence
Evidence by cancer (4 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 29504894
- Run
- ING-CIVIC-20260908-000001
| Molecular profile | Therapy | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| Lung Adenocarcinoma1 | ||||||||
| KRAS KRAS4A underexpression | (prognostic) | Prognostic | B | Supports Poor Outcome | 4 | submitted | EID9600In a clinical study including 148 patients expressing KRAS mutants, low expression of KRAS4A is significantly associated with decreased OS (p = 2.72 x 10^-3) and low proportion of KRAS4A is also signi… (full text at CIViC) PMID 29504894 · Yang et al., 2018 · Open in CIViC | civic |
| Malignant Colorectal Neoplasm2 | ||||||||
| KRAS KRAS4A underexpression | (prognostic) | Prognostic | B | Supports Poor Outcome | 4 | submitted | EID9598In a clinical study including 285 patients, KRAS4A low expression is significantly correlated with reduced OS by a multivariate analysis (p = 0.0038). Such significant correlation is observed in the w… (full text at CIViC) PMID 19824059 · | |
ClinVar
Clinical significance (0)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
Data not yet available