KIT D579del

CI-VAR-00000505Explore in graph →NP_000213.1:p.Asp579delNM_000222.2:c.1735_1737delGATClinVar 409725 CIViC 977 rs1060502543

Curated evidence

Evidence by cancer (4 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–4 of 4 evidence items across 2 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Gastrointestinal Stromal Tumor3
KIT D579del	Imatinib	Predictive	D	Supports Sensitivity Response	—	submitted	EID2485 Molecular models predict that deletion of a portion of the juxtamembrane domain relieves steric hindrance and results in higher binding affinity for imatinib. PMID 21364689 · Pierotti et al., 2011 · Open in CIViC	civic
KIT D579del	Sunitinib	Predictive	C	Supports Resistance	2	accepted	EID4142 Patient 74 from a larger cohort of genotyped patients (n= 78) with imatinib resistant or intolerant gastrointestinal stromal tumors (GISTs) harbored a primary (pre-imatinib treatment) KIT D579 deletio… (full text at CIViC) PMID 18955458 · Heinrich et al., 2008 · Open in CIViC	civic
KIT D579del

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
409725	Pathogenic	criteria provided, multiple submitters, no conflicts	2	Gastrointestinal stromal tumor; Hereditary cancer-predisposing syndrome	germline/somatic	4	Aug 30, 2025	clinvar

Sinonasal Undifferentiated Carcinoma1
KIT D579del	Imatinib Mesylate	Predictive	C	Supports Sensitivity Response	4	submitted	EID7252 Molecularly guided treatment with imatinib in analogy to the management of gastrointestinal stromal tumor (GIST) resulted in a dramatic and durable response with remission of nearly all tumor manifest… (full text at CIViC) PMID 27687311 · Dieter et al., 2017 · Open in CIViC	civic