IDH2 R172K

CI-VAR-00003717Explore in graph →NP_002159.2:p.Arg172LysNM_002168.3:c.515G>AClinVar 375987 CIViC 63 rs121913503

Curated evidence

Evidence by cancer (4 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–4 of 4 evidence items across 3 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Acute Myeloid Leukemia2
IDH2 R172K	(prognostic)	Prognostic	B	Does Not Support N/A	2	accepted	EID331 AML patients with IDH2 mutations such as R172K have event free survival and overall survival similar to those with wild-type IDH2. PMID 22616558 · Zhou et al., 2012 · Open in CIViC	civic
IDH2 R172K	(prognostic)	Prognostic	B	Supports Poor Outcome	3	accepted	EID375 In AML, patients with an IDH2 R172K mutation have worse overall survival compared to those with wild-type IDH2. PMID 21596855 · Green et al., 2011 · Open in CIViC	civic
Low Grade Glioma1
IDH2 R172K OR IDH2 R172G OR IDH2 R172W

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
375987	risk factor	no assertion criteria provided	0	Acute myocardial infarction; Neoplasm; IDH-mutant and 1p/19q-codeleted oligodendroglioma; Astrocytoma IDH-mutant	somatic	3	—	clinvar

Myelodysplastic Syndrome1
IDH2 R172K	(prognostic)	Prognostic	B	Does Not Support N/A	2	accepted	EID332 In patients suffering from MDS, the presence of IDH2 mutations such as R172K do not confer prognostic value (overall survival). PMID 21997850 · Lin et al., 2012 · Open in CIViC	civic