HSP90B1 Overexpression

CI-VAR-00003225Explore in graph →CIViC 3732

Curated evidence

Evidence by cancer (1 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–1 of 1 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Glioma1
HSP90B1 Overexpression	Onalespib + TemozolomideCombination	Predictive	D	Supports Sensitivity Response	2	submitted	EID10153 In vivo overexpression of HSP90 was observed in segments of the glioma-containing tissue versus the non-tumor-bearing areas in the forebrain of nude mice implanted with bioluminescent intracranial gli… (full text at CIViC) PMID 28679777 · Canella et al., 2017 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.