FGFR3 F384L

CI-VAR-00001113Explore in graph →NP_000133.1:p.Phe384LeuNM_000142.4:c.1150T>CClinVar 134404 CIViC 3516

Curated evidence

Evidence by cancer (3 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–3 of 3 evidence items across 3 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Multiple Myeloma1
FGFR3 F384L	Midostaurin	Predictive	D	Supports Sensitivity Response	2	submitted	EID10410 Cell line LP1 expressing FGFR3 F384L was treated with small molecule inhibitor PKC412, with relative viability rising above 1.1/1.0 at both 50 nM and 100 nM. Relative viability dropped to 0.96/1.0 at … (full text at CIViC) PMID 16091734 · Chen et al., 2005 · Open in CIViC	civic
Transitional Cell Carcinoma1
FGFR3 F384L	Infigratinib	Predictive	C	Does Not Support Sensitivity Response	2	submitted	EID6415 In this one-arm study, 67 patients with metastastic urothelial carcinoma and diverse FGFR3 alterations were treated with pan-FGFR Inhibitor BGJ398. The majority of patients (70.1%) had received two or… (full text at CIViC) PMID ·

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.

Hypochondroplasia1unmapped disease
FGFR3 F384L	(predisposing)	Predisposing	C	Supports Predisposition	1	submitted	EID9707 A rare variant was found through Sanger sequencing on affected members of a family with short stature. The segregation of the variant was not entirely related to the phenotype since it was present in … (full text at CIViC) PMID 25777271 · Kant et al., 2015 · Open in CIViC	civic