EGFR T725M

CI-VAR-00004336Explore in graph →NP_005219.2:p.Thr725MetNM_005228.3:c.2174C>TCIViC 861 rs767505234

Curated evidence

Evidence by cancer (2 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–2 of 2 evidence items across 2 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Lung Adenocarcinoma1
EGFR T725M	Unspecified therapy	Predictive	D	Supports N/A	3	submitted	EID1973 T725M and L861R are rare cancer-associated mutations and increase EGFR activity in the absence of the activating EGF ligand in cell-based assays PMID 24743239 · U et al., 2014 · Open in CIViC	civic
Unmapped disease1unmapped disease
EGFR T725M	(functional)	Functional	D	Supports Gain Of Function	3	submitted	EID10037 EGFR mutations were selected (L861R, G724S, T725M, L858Q, E746K) using an ensemble machine learning approach to prioritize variants. CHO cells were transfected with EGFR-mutant or WT to functionally c… (full text at CIViC) PMID 24743239 · U et al., 2014 · Open in CIViC

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.