EGFR S464T

CI-VAR-00004074Explore in graph →NP_005219.2:p.Ser464ThrNM_005228.5:c.1390T>AClinVar 854970 CIViC 2602 rs746763556

Curated evidence

Evidence by cancer (1 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–1 of 1 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Malignant Colorectal Neoplasm1
EGFR S464T	Cetuximab + PanitumumabSubstitutes	Predictive	B	Supports Resistance	3	submitted	EID7082 Next-generation sequencing data from cfDNA of 1,397 patients with colorectal cancer identified a novel cluster of extracellular domain (ECD) mutations in EGFR, mediating resistance by blocking binding… (full text at CIViC) PMID 29196463 · Strickler et al., 2018 · Open in CIViC	civic

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
854970	Uncertain significance	criteria provided, multiple submitters, no conflicts	2	EGFR-related lung cancer; Hereditary cancer-predisposing syndrome	germline	2	Feb 02, 2026	clinvar