RAD51 e24::e4

CI-VAR-00004946Explore in graph →CIViC 5144

Curated evidence

Evidence by cancer (2 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–2 of 2 evidence items across 2 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Lung Adenocarcinoma1
EGFR::RAD51 e24::e4	Afatinib	Predictive	C	Supports Sensitivity Response	3	accepted	EID12369 A 62 year-old female never smoker diagnosed of lung adenocarcinoma that was negative for EGFR and ALK alterations (EGFR hotspot tissue NGS) was treated with carboplatin/ pemetrexed/ bevacizumab (x 6 c… (full text at CIViC) PMID 29472054 · Raez et al., 2018 · Open in CIViC	civic
Lung Non-Small Cell Carcinoma1
EGFR::RAD51 e24::e4	Erlotinib	Predictive	C	Supports Sensitivity Response	4	accepted	EID12360 A 48 year old male with lung adenocarcinoma who was a smoker presented with diminished vision and tinnitus, and multiple intracranial brain metastasis were identified by CT. Metastatic site was submit… (full text at CIViC) PMID 29290255 ·

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.