EGFR R165Q

CI-VAR-00003700Explore in graph →ClinVar 1000496 CIViC 3470 rs761795138

Curated evidence

Evidence by cancer (3 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–3 of 3 evidence items across 3 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Malignant Colorectal Neoplasm1
EGFR R165Q	Cetuximab + PanitumumabSubstitutes	Predictive	D	Supports Sensitivity Response	4	submitted	EID9597 Oncogenic somatic EGFR mutations found in colorectal cancer samples were tested for sensitivity to EGFR inhibitors cetuximab and panitumumab. Ba/F3 cells expressing EGFR R165Q showed a dose-dependent … (full text at CIViC) PMID 31290142 · Kim et al., 2020 · Open in CIViC	civic
Malignant Neoplasm1
EGFR R165Q	(oncogenic)	Oncogenic	D	Supports Oncogenicity	3	submitted	EID9596 The oncogenic potential of somatic EGFR mutations found in colorectal cancer samples were tested. IL-3 independent growth of Ba/F3 cells was achieved when cells were transduced with EGFR R165Q. NIH-3T…

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
1000496	Conflicting classifications of pathogenicity	criteria provided, conflicting classifications	1	EGFR-related lung cancer; EGFR-related disorder; Hereditary cancer-predisposing syndrome	germline	4	Apr 04, 2025	clinvar

Unmapped disease1unmapped disease
EGFR R165Q	(functional)	Functional	D	Supports Gain Of Function	3	submitted	EID9595 Ba/F3 cells transfected with EGFR R165Q had levels of p-EGFR, p-STAT5, and p-AKT that were similar to known activating mutation L858R and higher than in cells expressing wild-type EGFR. PMID 31290142 · Kim et al., 2020 · Open in CIViC	civic