PPARGC1A Fusion

CI-VAR-00001343Explore in graph →CIViC 4283

Curated evidence

Evidence by cancer (2 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–2 of 2 evidence items across 2 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Skin Squamous Cell Carcinoma1
EGFR::PPARGC1A Fusion	(diagnostic)	Diagnostic	D	Supports Positive	2	submitted	EID10997 By transcriptome sequencing, they identified the fusion variant EGFR::PPARGC1A in around 30% (31 out of 102) of cutaneous squamous cell carcinoma (cSCC). They found that the lesions harboring the fusi… (full text at CIViC) PMID 28978917 · Egashira et al., 2017 · Open in CIViC	civic
Unmapped disease1unmapped disease
EGFR::PPARGC1A Fusion	(functional)	Functional	D	Supports Gain Of Function	3	submitted	EID11157 Figure 3. NIH3T3 cells stably transduced with lentiviral expression vector for EGFR, PPARGC1A or EGFR (exon 16)::PPARGC1A (exon2) fusion, or control were implanted into nude mice. Control and PPARGC1A… (full text at CIViC)

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.