Gene

PPARGC1A

PPARG coactivator 1 alpha

Curated evidence

Clinical evidence (2)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–2 of 2 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
PPARGC1A Fusion2
(functional)	—UNRESOLVED	Functional	D	Supports Gain Of Function	3	submitted	EID11157 Figure 3. NIH3T3 cells stably transduced with lentiviral expression vector for EGFR, PPARGC1A or EGFR (exon 16)::PPARGC1A (exon2) fusion, or control were implanted into nude mice. Control and PPARGC1A… (full text at CIViC) PMID 28978917 · Egashira et al., 2017 · Open in CIViC	civic
(diagnostic)	Skin Squamous Cell Carcinoma	Diagnostic	D	Supports Positive	2	submitted	EID10997 By transcriptome sequencing, they identified the fusion variant EGFR::PPARGC1A in around 30% (31 out of 102) of cutaneous squamous cell carcinoma (cSCC). They found that the lesions harboring the fusi… (full text at CIViC) PMID 28978917 · Egashira et al., 2017 ·

Cohorts

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

Data not yet available

No cohort frequency recorded for this gene.

Literature

Data not yet available

No publication linked to this gene yet.