EGFR P596L

CI-VAR-00003368Explore in graph →NP_005219.2:p.Pro596LeuNM_005228.5:c.1787C>TClinVar 1058870 CIViC 3489 rs1477025000

Curated evidence

Evidence by cancer (3 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–3 of 3 evidence items across 3 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Malignant Colorectal Neoplasm1
EGFR P596L	Cetuximab + PanitumumabSubstitutes	Predictive	D	Supports Sensitivity Response	3	submitted	EID9658 Oncogenic somatic EGFR mutations found in colorectal cancer samples were tested for sensitivity to EGFR inhibitors cetuximab and panitumumab. Ba/F3 cells expressing EGFR P596L showed a dose-dependent … (full text at CIViC) PMID 31290142 · Kim et al., 2020 · Open in CIViC	civic
Malignant Neoplasm1
EGFR P596L	(oncogenic)	Oncogenic	D	Supports Oncogenicity	3	submitted	EID9648 The oncogenic potential of somatic EGFR mutations found in colorectal cancer samples were tested. IL-3 independent growth of Ba/F3 cells was achieved when cells were transduced with EGFR P596L. NIH-3T…

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
1058870	Uncertain significance	criteria provided, multiple submitters, no conflicts	2	EGFR-related lung cancer; Neoplasm; Hereditary cancer-predisposing syndrome	germline/somatic	3	Sep 24, 2025	clinvar

Unmapped disease1unmapped disease
EGFR P596L	(functional)	Functional	D	Supports Gain Of Function	3	submitted	EID9640 Ba/F3 cells transfected with EGFR P596L had levels of p-EGFR, p-STAT5, and p-AKT that were similar to known activating mutation L858R and higher than in cells expressing wild-type EGFR. PMID 31290142 · Kim et al., 2020 · Open in CIViC	civic