Variant · Indel

EGFR L747_T751delinsP

CI-VAR-00002407Explore in graph →NP_001333827.1:p.Leu747_Thr751delinsProNM_001346898.2:c.2239_2251delinsCClinVar 16610 CIViC 1010 rs397509368

Curated evidence

Evidence by cancer (6 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–6 of 6 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Lung Non-Small Cell Carcinoma6
EGFR L747_T751delinsP	Afatinib	Predictive	C	Supports Sensitivity Response	—	submitted	EID2581 In a phase 2b/3 study of 585 stage IIIB-IV lung adenocarcinoma patients who had a previous round of EGFR-TKI treatment, archival material was available for 141 patients. EGFR mutational analysis revea… (full text at CIViC) PMID 22452896 · Miller et al., 2012 · Open in CIViC	civic
EGFR L747_T751delinsP	Afatinib	Predictive	C	Supports Sensitivity Response	—	submitted	EID2582 A phase 3 study of 345 stage IIIB-IV lung adenocarcinoma patients, reported improved median progression free survival (13.6 months vs. 6.9 months, HR: 0.47, 95% CI: 0.34-0.65, P=0.001) in EGFR mutatio… (full text at CIViC) PMID 23816960 · Sequist et al., 2013 · Open in CIViC

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
16610	drug response	no assertion criteria provided	0	Nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, somatic; Tyrosine kinase inhibitor response	somatic	2	Oct 28, 2006	clinvar