EGFR L718V

CI-VAR-00002389Explore in graph →CIViC 3000

Curated evidence

Evidence by cancer (5 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–5 of 5 evidence items across 2 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Lung Adenocarcinoma4
EGFR L718Q AND EGFR L718V	Afatinib	Predictive	C	Does Not Support Resistance	3	submitted	EID8054 A 62 year old patient with 4 pack-year smoking history with back and flank pain was found to have metastatic lung adenocarcinoma by CT and MRI. Targeted NGS sequencing discovered an EGFR L858R mutatio… (full text at CIViC) PMID 32193290 · Starrett et al., 2020 · Open in CIViC	civic
EGFR L718Q AND EGFR L718V	Osimertinib	Predictive	C	Supports Resistance	4	submitted	EID8052 A 62 year old patient with 4 pack-year smoking history with back and flank pain was found to have metastatic lung adenocarcinoma by CT and MRI. Targeted NGS sequencing discovered an EGFR L858R mutatio… (full text at CIViC) PMID 32193290 · Starrett et al., 2020 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.

Malignant Neoplasm1
EGFR L718V	Afatinib	Predictive	D	Supports Sensitivity Response	2	submitted	EID8074 Preclinical models of osimertinib-resistant EGFR mutants were treated with erlotinib or afatinib. Treatment with afatinib suppressed EGFR phosphorylation of L858R+L797S, and caused complete inhibition… (full text at CIViC) PMID 32193290 · Starrett et al., 2020 · Open in CIViC	civic