DUX4 Fusion

CI-VAR-00001183Explore in graph →CIViC 524

Curated evidence

Evidence by cancer (3 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–3 of 3 evidence items across 2 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Acute Lymphoblastic Leukemia2
DUX4::v Fusion	(prognostic)	Prognostic	C	Supports Better Outcome	3	accepted	EID1277 Ph- ALL (Philadelphia chromosome negative acute lymphoblastic leukemia) gene expression profiles cluster into two main groups, Ph like and non-Ph like ALL. Non-Ph like ALL have favorable outcomes whe… (full text at CIViC) PMID 27019113 · Yasuda et al., 2016 · Open in CIViC	civic
DUX4::v Fusion	(diagnostic)	Diagnostic	D	Supports Positive	4	accepted	EID1276 A screen for fusion genes in Ph- AYA-ALL (Philadelphia chromosome negative acute lymphoblastic leukemia in adolescents and young adults) was performed using RNA-seq from multiple cohorts of ALL patien… (full text at CIViC) PMID 27019113 · Yasuda et al., 2016 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.

B Acute Lymphoblastic Leukemia with DUX4 Rearrangement1
DUX4::v Fusion OR v::DUX4 Fusion	(diagnostic)	Diagnostic	B	Supports Positive	4	submitted	EID11523 Integrated genomic analysis of was performed for 1,988 childhood and adult B-ALL cases. 106 cases (5.3%) showed DUX4 rearrangements, commonly with the IGH region. These cases were characterized by a u… (full text at CIViC) PMID 30643249 · Gu et al., 2019 · Open in CIViC	civic