Variant · Snv
RPGR NM_001034853.2(RPGR):c.1274G>A (p.Arg425Lys)
CI-VAR-00018520Explore in graph →p.Arg425LysNM_001034853.2:c.1274G>AClinVar 98734 rs1801687
Curated evidence
Evidence by cancer (0 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
Data not yet available
No curated evidence item references this variant yet.
ClinVar
Clinical significance (1)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
clinvarProvenance
- Source
- NCBI ClinVar (variant_summary)
- Dataset
- ClinVar variant_summary
- Version
- 2026-09-14
- Retrieved
- Sep 15, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- database
- License
- Public domain (US Government work, NCBI/NLM); acknowledgment requested
- Run
- ING-CLINVAR-20260915-000001
| Variation | Clinical significance | Review status | Stars | Conditions | Origin | Submitters | Last evaluated | Source |
|---|---|---|---|---|---|---|---|---|
| 98734 | Benign | reviewed by expert panel | 3 | Primary ciliary dyskinesia; Retinal dystrophy; RPGR-related retinopathy; Uterine carcinosarcoma; Melanoma; Colorectal cancer; Thymoma; Cholangiocarcinoma; Acute myeloid leukemia; Malignant tumor of esophagus; Adrenocortical carcinoma, hereditary; Uveal melanoma; Colon adenocarcinoma | germline | 14 | Aug 01, 2025 | clinvar |