Variant · Snv
ACTN4 NM_004924.6(ACTN4):c.369C>T (p.Gly123=)
CI-VAR-00047818Explore in graph →p.Gly123=NM_004924.6:c.369C>TClinVar 259578 rs140381330
Curated evidence
Evidence by cancer (0 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
Data not yet available
No curated evidence item references this variant yet.
ClinVar
Clinical significance (1)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
clinvarProvenance
- Source
- NCBI ClinVar (variant_summary)
- Dataset
- ClinVar variant_summary
- Version
- 2026-09-24
- Retrieved
- Sep 29, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- database
- License
- Public domain (US Government work, NCBI/NLM); acknowledgment requested
- Run
- ING-CLINVAR-20260929-000001
| Variation | Clinical significance | Review status | Stars | Conditions | Origin | Submitters | Last evaluated | Source |
|---|---|---|---|---|---|---|---|---|
| 259578 | Benign/Likely benign | criteria provided, multiple submitters, no conflicts | 2 | Focal segmental glomerulosclerosis 1; Focal segmental glomerulosclerosis; Clear cell carcinoma of kidney; Colon adenocarcinoma; Cholangiocarcinoma; Hepatocellular carcinoma; Cervical cancer; Uveal melanoma; Sarcoma; Melanoma; Acute myeloid leukemia; Uterine corpus endometrial carcinoma; Malignant tumor of esophagus; Nonpapillary renal cell carcinoma; Adrenocortical carcinoma, hereditary; Lung cancer; Gastric cancer; Ovarian serous cystadenocarcinoma; Thymoma; Thyroid cancer, nonmedullary, 1 | germline | 9 | Jan 30, 2026 | clinvar |