NRAS NM_002524.5(NRAS):c.35G>C (p.Gly12Ala)

CI-VAR-00034699Explore in graph →p.Gly12AlaNM_002524.5:c.35G>CClinVar 219097 rs121913237

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
219097	Pathogenic/Likely pathogenic	criteria provided, multiple submitters, no conflicts	2	Myelodysplastic syndrome progressed to acute myeloid leukemia; RASopathy; Noonan syndrome and Noonan-related syndrome; Autoimmune lymphoproliferative syndrome type 4; Colorectal cancer; Embryonal rhabdomyosarcoma; Germinoma; Noonan syndrome 6	germline/somatic	8	Apr 14, 2025	clinvar