CCNE1 Overexpression

CI-VAR-00003125Explore in graph →CIViC 24

Curated evidence

Evidence by cancer (7 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–7 of 7 evidence items across 3 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Gastric Adenosquamous Carcinoma2
CCNE1 Overexpression	(prognostic)	Prognostic	B	Supports Poor Outcome	4	rejected	EID364 Elevated levels of CCNE1 mRNA has been shown to be correlated with advanced stage gastric carcinoma. PMID 10224221 · Donnellan et al., 1999 · Open in CIViC	civic
CCNE1 Overexpression	(prognostic)	Prognostic	B	Supports Poor Outcome	4	accepted	EID365 Elevated levels of CCNE1 mRNA has been shown to be correlated with increased depth of tumor invasion in gastic carcinoma. PMID 10224221 · Donnellan et al., 1999 · Open in CIViC	civic
Malignant Breast Neoplasm3

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.

Malignant Ovarian Neoplasm2
CCNE1 Overexpression	CDK Inhibitor SNS-032	Predictive	D	Supports Sensitivity Response	2	accepted	EID1734 Four ovarian cancer cell lines with elevated CCNE1 expression were 40x more sensitive to Cdk2 inhibitor SNS-032 than four cell lines without CCNE1 overexpression. SNS-032 greatly prolonged the surviva… (full text at CIViC) PMID 26204491 · Yang et al., 2015 · Open in CIViC	civic
CCNE1 Overexpression	Palbociclib	Predictive	D	Supports Resistance	3	submitted	EID7792 The effect of high CCNE1 expression on PD0332991 (palbociclib) sensitivity was observed in cell lines. One PD0332991 sensitive cell line, HEY, was engineered to constitutively express CCNE1 (HEY-CCNE… (full text at CIViC) PMID 25557169 · Taylor-Harding et al., 2015 · Open in CIViC	civic