ALK G881D

CI-VAR-00001846Explore in graph →CIViC 5536

Curated evidence

Evidence by cancer (2 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–2 of 2 evidence items across 2 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Lung Adenocarcinoma1
ALK G881D AND ALK Y1239H AND ALK V597A AND ALK S413N	(oncogenic)	Oncogenic	D	Supports Oncogenicity	2	submitted	EID13125 Analysis of 48 lung adenocarcinomas identified novel ALK mutations in six tumours, including S413N in the MAM1 domain, V597A in the MAM2, H694R in an undefined region, G881D in the glycine-rich domain… (full text at CIViC) PMID 21847362 · Wang et al., 2011 · Open in CIViC	civic
Unmapped disease1unmapped disease
ALK H694R AND ALK G881D AND ALK E1384K AND ALK V597A	(functional)	Functional	D	Supports Gain Of Function	3	submitted	EID13123 Analysis of 48 lung adenocarcinomas identified novel ALK mutations in six tumours, including S413N in the MAM1 domain, V597A in the MAM2, H694R in an undefined region, G881D in the glycine-rich domain… (full text at CIViC)

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.