ALK G1128A

CI-VAR-00001573Explore in graph →NP_001340694.1:p.Gly60AlaNM_001353765.1:c.179G>CClinVar 18084 CIViC 2798 rs113994088

Curated evidence

Evidence by cancer (2 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–2 of 2 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Neuroblastoma2
ALK G1128A	(predisposing)	Predisposing	B	Supports Predisposition	4	rejected	EID7568 A genome-wide scan of single nucleotide polymorphisms in twenty neuroblastoma families identified the ALK gene as being disease linked. Sequencing of ALK exons identified 3 mutations, including G1128A… (full text at CIViC) PMID 18724359 · Mossé et al., 2008 · Open in CIViC	civic
ALK G1128A	(predisposing)	Predisposing	B	Supports Predisposition	4	submitted	EID7570 A genome-wide scan of single nucleotide polymorphisms in twenty neuroblastoma families identified the ALK gene as being disease linked. Sequencing of ALK exons identified 3 mutations, including G1128A… (full text at CIViC) PMID 18724359 · Mossé et al., 2008 · Open in CIViC	civic

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
18084	Pathogenic; risk factor	no assertion criteria provided	0	Neuroblastoma, susceptibility to, 3; Neuroblastoma	germline/somatic	4	Oct 07, 2015	clinvar