Variant · Snv

ABL1 T315I

CI-VAR-00004310Explore in graph →NP_005148.2:p.Thr315IleNM_007313.2:c.1001C>TClinVar 12624 CIViC 2 rs121913459

Curated evidence

Evidence by cancer (54 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 51–54 of 54 evidence items across 2 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Chronic Myeloid Leukemia, BCR-ABL1 Positive3
BCR::ABL1 Fusion AND ABL1 T315I AND ABL1 H396R	Axitinib	Predictive	D	Supports Sensitivity Response	2	submitted	EID12317 In an in vitro study, pro-B Ba/F3 cell line expressing a compound mutant of both H396R and T315I mutations in the ABL1 portion of the BCR-ABL1 fusion protein demonstrated increased sensitivity to axit… (full text at CIViC) PMID 26582647 · Zabriskie et al., 2016 · Open in CIViC	civic
BCR::ABL1 Fusion AND ABL1 T315I AND ABL1 M244V	Axitinib	Predictive	D	Supports Sensitivity Response	2	submitted	EID12315 In an in vitro study, pro-B Ba/F3 cell line expressing a compound mutant of both M244V and T315I mutations in the ABL1 portion of the BCR-ABL1 fusion protein demonstrated increased sensitivity to axit… (full text at CIViC) PMID 26582647 · Zabriskie et al., 2016 ·

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
12624	Likely pathogenic; association	criteria provided, multiple submitters, no conflicts	2	Leukemia, Philadelphia chromosome-positive, resistant to imatinib; Chronic myeloid leukemia	germline/somatic	3	Sep 13, 2023	clinvar