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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
16,115 stopped studies · 89% state a reason
Over the 16,115 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT00034138 | A Comparative Pharmacokinetics and Safety Study of OvaRex MAb-B43.13 in Patients With… | Phase 1 / Phase 2 | terminated | Apr 24, 2002 | Unither Pharmaceuticals | closed by sponser | Other (stated, no rule matched) |
| NCT00034372 | Multicenter Clinical Trial of Intravenous OvaRex MAb-B43.13 as Post-Chemotherapy… | Phase 2 | terminated | Apr 29, 2002 | Unither Pharmaceuticals | closed by sponser | Other (stated, no rule matched) |
| NCT00050375 | Clinical Trial for Ovarian Cancer (OvaRex®) | Phase 3 | terminated | Dec 6, 2002 | Unither Pharmaceuticals | Study closed by sponser | Other (stated, no rule matched) |
| NCT00086632 | Study of Ovarex® (Oregovomab) MAb With Front-Line Chemotherapy for Ovarian Cancer… | Phase 2 | terminated | Jul 9, 2004 | Unither Pharmaceuticals | closed by sponser | Other (stated, no rule matched) |
| NCT00257881 | Study Evaluating Intravenous CMD-193 in Subjects With Advanced Malignant Solid Tumors | Phase 1 | terminated | Nov 23, 2005 | Wyeth is now a wholly owned subsidiary of Pfizer | not stated | Not stated |
| NCT00131651 | ATN-161 in Advanced Renal Cell Cancer | Phase 2 | terminated | Aug 19, 2005 | Attenuon | not stated | Not stated |
| NCT00367497 | Safety and Efficacy Study of Salvage Chemotherapy (R-ESHAP) to Treat Relapsed and… | Phase 2 | terminated | Aug 23, 2006 | Keio University | The stopping rule was applied because of low response rates. | Other (stated, no rule matched) |
| NCT00120172 | Study of Oxaliplatin, Capecitabine, and Bevacizumab to Treat Older Patients With… | Phase 2 | terminated | Jul 15, 2005 | Geriatric Oncology Consortium | positive results from a larger study with same regimen was released. | Other (stated, no rule matched) |
| NCT00120198 | Pegylated Liposomal Doxorubicin Containing Chemotherapy in the Treatment of Older… | Phase 2 | terminated | Jul 15, 2005 | Geriatric Oncology Consortium | slow accrual | Enrollment / accrual |
| NCT00215748 | Reduced Dexamethasone Pre-Medication Dose in Elderly Patients Receiving Weekly Docetaxel | Phase 2 | terminated | Sep 22, 2005 | Geriatric Oncology Consortium | slow accrual | Enrollment / accrual |
| NCT00559351 | RCT on the Combined Modality Treatment of Squamous Cell Carcinoma of the Esophagus | Phase 3 | terminated | Nov 16, 2007 | Ministry of Scientific Research and Information Technology, Poland | difficulty in recruitment | Enrollment / accrual |
| NCT00216424 | Capecitabine (Xeloda) and Radiation for Patients With Rectosigmoid Carcinoma | Phase 4 | terminated | Sep 22, 2005 | James A. Haley Veterans Administration Hospital | lack of accrual | Enrollment / accrual |
| NCT00216437 | Dose Escalation Study Combining Oral Capecitabine (Xeloda) and Radiotherapy for Patients… | Phase 1 | terminated | Sep 22, 2005 | James A. Haley Veterans Administration Hospital | lack of accrual | Enrollment / accrual |
| NCT00273338 | DN-101 in Combination With Docetaxel in Androgen-Independent Prostate Cancer (AIPC) (AIPC… | Phase 3 | terminated | Jan 9, 2006 | Novacea | DSMB | Other (stated, no rule matched) |
| NCT00536770 | A Study of Gemcitabine ± Erlotinib and DN-101 Versus Gemcitabine ± Erlotinib and Placebo… | Phase 2 | suspended | Sep 28, 2007 | Novacea | DSMB | Other (stated, no rule matched) |
| NCT00385021 | ChronoFOLFOX Plus Avastin for Patients With Metastatic Colorectal Cancer | Phase 2 | terminated | Oct 6, 2006 | Southwestern Regional Medical Center | not stated | Not stated |
| NCT00047632 | Safety and Efficacy of Interferon Gamma-1b Plus Chemotherapy for Ovarian and Peritoneal… | Phase 3 | terminated | Oct 11, 2002 | InterMune | futility | Efficacy / futility |
| NCT00057447 | Safety of Interferon Gamma-1b With Rituximab in Non-Hodgkin's Lymphoma Patients | Phase 1 / Phase 2 | terminated | Apr 3, 2003 | InterMune | administrative reasons | Other (stated, no rule matched) |
| NCT00209677 | Phase I/II Study of Oral S-1 Plus Gemcitabine in Patients With Metastatic Pancreatic… | Phase 1 / Phase 2 | suspended | Sep 21, 2005 | Hokkaido Gastrointestinal Cancer Study Group | Unfortunately, other Phase III clinical Study (GEM+S-1 vs GEM vs S-1) have been started in Japan. h | Other (stated, no rule matched) |
| NCT00316745 | IRIS Followed by mFOLFOX6 or the Reverse Sequence in Advanced Colorectal Cancer | Phase 3 | suspended | Apr 21, 2006 | Hokkaido Gastrointestinal Cancer Study Group | Because of approval of Bevacizumab, it was difficult to perform clinical study in 1st line setting. | Other (stated, no rule matched) |
| NCT00267553 | Treatment and Survival Continuation Study of Atamestane Plus Toremifene vs Letrozole in… | Phase 3 | terminated | Dec 21, 2005 | Intarcia Therapeutics | This was a follow-on study to Biomed 777-CLP-029 which did not meet superiority endpoint | Other (stated, no rule matched) |
| NCT00255268 | CMAB vs IMAB in Metastatic Prostate Cancer | Phase 4 | withdrawn | Nov 18, 2005 | AstraZeneca | not stated | Not stated |
| NCT00097344 | The CAT Study: Atamestane Plus Toremifene Versus Letrozole in Advanced Breast Cancer | Phase 3 | terminated | Nov 23, 2004 | Intarcia Therapeutics | Identical study Biomed 777-CLP-029 did not meet superiority endpoint | Other (stated, no rule matched) |
| NCT00386997 | ProphyALL - Study on the Safety of Liposomal Amphotericin B to Prevent Antifungal… | Phase 4 | terminated | Oct 12, 2006 | Gilead Sciences | Study closed due to recruitment challenges. | Enrollment / accrual |
| NCT00189579 | Addition of Herceptin to a Carboplatin-Paclitaxel Regimen in Patients With Ovarian Cancer | Phase 2 | terminated | Sep 19, 2005 | ARCAGY/ GINECO GROUP | not stated | Not stated |
| NCT00061646 | Safety and Effectiveness of ABT-510 Plus Combination Chemotherapy in Subjects With… | Phase 2 | terminated | Jun 4, 2003 | Abbott | Enrollment suspended based upon interim analysis; subjects allowed to stay on study until disease… | Efficacy / futility |
| NCT00514332 | Comparison Between Colorectal Stents and Primary Surgery in Obstructive Colonic Cancer. A… | N/A | terminated | Aug 9, 2007 | University Hospital, Montpellier | enrolling participants stopped | Enrollment / accrual |
| NCT00225550 | A Study of the Safety and Effects of ADH-1 Given Daily to Subjects With Solid Tumors | Phase 1 / Phase 2 | terminated | Sep 26, 2005 | Adherex Technologies, Inc. | not stated | Not stated |
| NCT00511121 | Study of the Combination of a Tyrosine Kinase Inhibitor (STI571) and a Pegylated Human… | Phase 2 | terminated | Aug 3, 2007 | University of Bologna | not stated | Not stated |
| NCT00100347 | Safety/Tolerance Study of PPI-2458 in Subjects With Non-Hodgkin's Lymphoma and Solid… | Phase 1 | terminated | Dec 30, 2004 | PRAECIS Pharmaceuticals Inc. | terminated due to corporate transaction. | Other (stated, no rule matched) |
| NCT00506168 | Study of Irinotecan & Capecitabine in Metastatic Colorectal Cancer | Phase 2 | terminated | Jul 25, 2007 | National Cancer Center, Korea | The study drugs are not covered anymore by insurance. | Other (stated, no rule matched) |
| NCT00195078 | Safety Trial of IRESSA, Cisplatin and Radiation Therapy for Patients With Head and Neck… | Phase 1 / Phase 2 | terminated | Sep 19, 2005 | Weill Medical College of Cornell University | not stated | Not stated |
| NCT00496743 | Study of Low-Dose Total Skin Electron Beam Therapy in Mycosis Fungoides | N/A | terminated | Jul 4, 2007 | Bispebjerg Hospital | The study was discontinued after the first 10 patients because of discouraging results. | Other (stated, no rule matched) |
| NCT00105313 | Study to Evaluate MEDI-507 in Patients With CD2-Positive Lymphoma/Leukemia | Phase 1 | terminated | Mar 14, 2005 | MedImmune LLC | After review of safety events and have decided that further dose escalation of MEDI-507 as a single… | Safety / toxicity |
| NCT00116389 | Trial of Talabostat and Gemcitabine in Patients With Stage IV Adenocarcinoma of the… | Phase 2 | terminated | Jun 29, 2005 | Point Therapeutics | FDA Hold May 2007 | Other (stated, no rule matched) |
| NCT00243204 | Study of Talabostat + Docetaxel Versus Docetaxel in Stage IIIB/IV Non-Small Cell Lung… | Phase 3 | terminated | Oct 21, 2005 | Point Therapeutics | FDA Hold May 2007 | Other (stated, no rule matched) |
| NCT00290017 | Study of Talabostat and Pemetrexed vs. Pemetrexed in Stage IIIB/IV Non-Small Cell Lung… | Phase 3 | terminated | Feb 10, 2006 | Point Therapeutics | FDA Hold May 2007 | Other (stated, no rule matched) |
| NCT00126893 | Study to Determine the Optimal Biologic Dose of CC-401 in Subjects With High-Risk Myeloid… | Phase 1 | terminated | Aug 5, 2005 | Celgene Corporation | not stated | Not stated |
| NCT00255333 | INNO-105 in Patients With Solid Tumors | Phase 1 | terminated | Nov 18, 2005 | Innovive Pharmaceuticals | Development of this compound was discontinued. | Other (stated, no rule matched) |
| NCT00080028 | Motexafin Gadolinium With Chemotherapy and Radiation Therapy for the Treatment of… | Phase 1 | terminated | Mar 23, 2004 | Pharmacyclics LLC. | not stated | Not stated |
| NCT00247988 | Weekly Carboplatin and Taxotere in Platinum Sensitive Relapsed Ovarian or Tubal or… | Phase 2 | terminated | Nov 2, 2005 | University of Saskatchewan | Regulatory issues(trial temporarily suspended December 28, 2005. Permanently suspended January 19,… | Other (stated, no rule matched) |
| NCT00143884 | Study of Low Intensity Conditioning and Immunotherapy for High-Risk Cancers of the Blood | Phase 2 | terminated | Sep 2, 2005 | University of Michigan Rogel Cancer Center | not stated | Not stated |
| NCT00225056 | Phase II Study of Capecitabine and Weekly Docetaxel Followed by Capecitabine Maintenance… | Phase 2 | terminated | Sep 23, 2005 | Oncology Specialties, Alabama | Terminated due to lack of accrual | Enrollment / accrual |
| NCT00229567 | Intra-op Lidocaine and Ketamine Effect on Postoperative Bowel Function | N/A | terminated | Sep 29, 2005 | University of Saskatchewan | insufficient numbers of eligible patients as laparscopic surgery increased and open surgery… | Other (stated, no rule matched) |
| NCT00106262 | Study of Velcade and Irinotecan in Advanced Cervical, Vulvar, or Vaginal Cancer | Phase 2 | terminated | Mar 22, 2005 | Women and Infants Hospital of Rhode Island | Lack of accrual | Enrollment / accrual |
| NCT00316433 | Oxaliplatin/CPT-11 for Extensive Stage Small Cell Lung Cancer | Phase 2 | terminated | Apr 20, 2006 | Swedish Medical Center | not stated | Not stated |
| NCT00195247 | Study Evaluating TTI-237 in Advanced Malignant Solid Tumors | Phase 1 | terminated | Sep 19, 2005 | Wyeth is now a wholly owned subsidiary of Pfizer | not stated | Not stated |
| NCT00195325 | Study Evaluating TTI-237 in Advanced Malignant Solid Tumors. | Phase 1 | terminated | Sep 19, 2005 | Wyeth is now a wholly owned subsidiary of Pfizer | not stated | Not stated |
| NCT00099281 | DPPE in Combination With Epirubicin and Cyclophosphamide in the Treatment of Breast Cancer | Phase 3 | terminated | Dec 10, 2004 | YM BioSciences | not stated | Not stated |
| NCT00287482 | Essiac (ESIAK) Versus Placebo to Improve Quality of Life in Transition in Women With… | N/A | terminated | Feb 6, 2006 | Women and Infants Hospital of Rhode Island | not stated | Not stated |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 22 days agoSource updated Dec 18, 2007source: clinicaltrials