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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
431 stopped studies mapped to Urinary System Carcinoma and descendants · 87% state a reason
Over the 431 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT01769885 | Tivozanib Before Surgery in Treating Patients With Localized Kidney Cancer | N/A | withdrawn | Jan 17, 2013 | Roswell Park Cancer Institute | not stated | Not stated |
| NCT04972253 | Phase I BLASST-3 Trial((BLASST)-3) | Phase 1 | withdrawn | Jul 22, 2021 | Guru P. Sonpavde | Low Accrual | Enrollment / accrual |
| NCT02781506 | Nivolumab and Stereotactic Ablative Radiation Therapy (SAbR) for Metastatic Clear Cell… | Phase 2 | terminated | May 24, 2016 | University of Texas Southwestern Medical Center | Since the treatment landscape for metastatic kidney cancer changed, patients were not becoming… | Other (stated, no rule matched) |
| NCT05263609 | Optimizing Pembrolizumab Therapy With Timing and Intensification With Axitinib | Phase 2 | withdrawn | Mar 2, 2022 | University of Oklahoma | PI left University | Investigator |
| NCT02901548 | Phase 2 Durvalumab (Medi4736) for Bacillus Calmette-Guérin (BCG) Refactory Urothelial… | Phase 2 | terminated | Sep 15, 2016 | H. Lee Moffitt Cancer Center and Research Institute | Study closed early due to futility | Efficacy / futility |
| NCT04596033 | TiTAN-1: Safety, Proliferation and Persistence of GEN-011 Autologous Cell Therapy | Phase 1 | terminated | Oct 22, 2020 | Genocea Biosciences, Inc. | Business reasons | Sponsor / business decision |
| NCT03050060 | Image Guided Hypofractionated Radiation Therapy, Nelfinavir Mesylate, Pembrolizumab,… | Phase 2 | terminated | Feb 10, 2017 | University of Washington | Terminated due to slow accrual | Enrollment / accrual |
| NCT04173338 | Cabozantinib With Pemetrexed in Advanced Non-small Cell Lung Cancer, Urothelial Cancer… | Phase 1 | terminated | Nov 21, 2019 | Augusta University | Closed by IRB on 3/28/22 | Other (stated, no rule matched) |
| NCT04961320 | Occupational Therapy Fatigue Management-Based Intervention for Metastatic Renal Cell… | N/A | withdrawn | Jul 14, 2021 | City of Hope Medical Center | slow accrual | Enrollment / accrual |
| NCT04150562 | Avelumab (Bavencio) With IL-15 in Subjects With Clear-Cell Renal Carcinoma | Phase 2 | terminated | Nov 4, 2019 | National Cancer Institute (NCI) | This study was terminated early due to manufacturer withdrawal of support (study medication) due to… | Drug supply |
| NCT03839472 | Continuous Bladder Irrigation Following Transurethral Resection of Bladder Tumors | N/A | withdrawn | Feb 15, 2019 | Case Comprehensive Cancer Center | Revision to improve cell recovery | Other (stated, no rule matched) |
| NCT05104905 | A Phase I/II Open Label Single Centre Trial to Assess the Safety, Tolerability and…(RENACOL) | Phase 1 / Phase 2 | withdrawn | Nov 3, 2021 | Faron Pharmaceuticals Ltd | Since no patients have been enrolled in RENACOL, and safety and tolerability data is rapidly… | Safety / toxicity |
| NCT03655613 | APL-501 or Nivolumab in Combination With APL-101 in Locally Advanced or Metastatic HCC… | Phase 1 / Phase 2 | terminated | Aug 31, 2018 | Apollomics (Australia) Pty. Ltd. | Study terminated due to administrative reasons. | Other (stated, no rule matched) |
| NCT03266900 | A Superiority Trial to Compare Re-resection of High-grade T1 Bladder Urothelial Carcinoma…(RESECT) | Early Phase 1 | terminated | Aug 30, 2017 | University Health Network, Toronto | Difficulties with accrual | Enrollment / accrual |
| NCT05234606 | A Safety and Preliminary Efficacy Study of SBT6290 Alone and in Combination With PD-(L)1… | Phase 1 / Phase 2 | withdrawn | Feb 10, 2022 | Silverback Therapeutics | Sponsor decision based on strategic re-alignment | Sponsor / business decision |
| NCT03334409 | Pazopanib Hydrochloride With or Without Ascorbic Acid in Treating Patients With Kidney… | Phase 2 | terminated | Nov 7, 2017 | Academic and Community Cancer Research United | Due to loss of funding from the private foundation source | Funding |
| NCT04960956 | Glycosylation of Exosomes in Prostate and Urothelial Carcinoma | — | terminated | Jul 14, 2021 | Indiana University | Could not identify a replacement Principal Investigator. | Investigator |
| NCT03138538 | M8891 First in Human in Solid Tumors(M8891) | Phase 1 | terminated | May 3, 2017 | EMD Serono Research & Development Institute, Inc. | As part of a portfolio-level management of the company's oncology pipeline, it was decided to stop… | Sponsor / business decision |
| NCT02459067 | ImmuniCell® in Patients With Advanced Cancers | Phase 2 | terminated | Jun 1, 2015 | TC Biopharm | not stated | Not stated |
| NCT03549650 | Prevention and Management of Intravesical BCG-related Lower Urinary Tract Symptoms | Phase 2 | terminated | Jun 8, 2018 | Sir Mortimer B. Davis - Jewish General Hospital | Given the updated precautions on Elmiron as well as the risk benefit profile, we have decided to… | Other (stated, no rule matched) |
| NCT01954173 | Adjuvant Radiation for High Risk Bladder Cancer | N/A | terminated | Oct 1, 2013 | Emory University | Slow accrual | Enrollment / accrual |
| NCT03875313 | Study of CB-839 (Telaglenastat) in Combination With Talazoparib in Patients With Solid… | Phase 1 / Phase 2 | terminated | Mar 14, 2019 | Calithera Biosciences, Inc | Slow Enrollment | Enrollment / accrual |
| NCT03035630 | Sunitinib Followed by Avelumab or the Reverse for Metastatic Renal Cell Carcinoma | Phase 2 | withdrawn | Jan 30, 2017 | Guru Sonpavde | Principal investigator left lead institution and efforts to open the protocol at another… | Investigator |
| NCT02628535 | Safety Study of MGD009 in B7-H3-expressing Tumors | Phase 1 | terminated | Dec 11, 2015 | MacroGenics | Business decision (not for safety reasons) | Safety / toxicity |
| NCT01093066 | Prospective Multicentric Evaluation of a Bladder Preservation Strategy(ReChiVe) | Phase 2 | terminated | Mar 25, 2010 | Centre Hospitalier Universitaire de Saint Etienne | Difficulties in the inclusion and follow-up of patients | Other (stated, no rule matched) |
| NCT03287050 | Anti-PD(L)1 and SBRT in the Treatment of Advanced, Platinum-Refractory Urothelial… | Phase 2 | terminated | Sep 19, 2017 | University of Michigan Rogel Cancer Center | due to changing therapeutic landscape in metastatic bladder cancer and lack of… | Other (stated, no rule matched) |
| NCT02767921 | sEphB4-HSA Before Surgery in Treating Patients With Bladder Cancer, Prostate Cancer, or… | Phase 1 | terminated | May 11, 2016 | University of Southern California | Insufficient accrual | Enrollment / accrual |
| NCT03408652 | Efficacy and Safety of Systemic Treatments of Bone Metastases From Kidney Cancer in…(MOSCAR) | Phase 3 | terminated | Jan 24, 2018 | Centre Leon Berard | lack of recruitment | Enrollment / accrual |
| NCT03115801 | A Phase II Randomized Trial of Immunotherapy Plus Radiotherapy in Metastatic… | Phase 2 | terminated | Apr 14, 2017 | Weill Medical College of Cornell University | Lack of accrual | Enrollment / accrual |
| NCT02885649 | Enzalutamide Before Surgery in Treating Patients With Kidney Cancer | Early Phase 1 | terminated | Aug 31, 2016 | Rutgers, The State University of New Jersey | Funding unavailable | Funding |
| NCT02959554 | Study in Which Therapy is Either Switched to Nivolumab After 3 Months of Treatment or…(NIVOSWITCH) | Phase 2 | terminated | Nov 9, 2016 | AIO-Studien-gGmbH | not stated | Not stated |
| NCT04066595 | Cabozantinib in Patients With Locally Advanced or Metastatic Urothelial Cell Carcinoma.(CabUC) | Phase 2 | terminated | Aug 26, 2019 | Johannes Gutenberg University Mainz | Recruitment problems | Enrollment / accrual |
| NCT04680416 | Tissue Collection to ID TCRs From Renal Clear Cell Carcinoma Patients Responding to… | — | withdrawn | Dec 23, 2020 | TScan Therapeutics, Inc. | Lack of patient samples | Other (stated, no rule matched) |
| NCT01649180 | NEXT: Subsequent Exposure to Tyrosine Kinase Inhibition at Recurrence After Adjuvant…(PrE0801) | Phase 2 | terminated | Jul 25, 2012 | PrECOG, LLC. | Closed due to prolonged enrollment timelines | Enrollment / accrual |
| NCT04579133 | Neoadjuvant Durvalumab Alone Versus Durvalumab With Olaparib in Patients Ineligible for… | Phase 2 | terminated | Oct 8, 2020 | Latin American Cooperative Oncology Group | Not approved | Other (stated, no rule matched) |
| NCT01147536 | Study of Vitespen (HSPPC-96, Oncophage ®) for Immune Response Assessment in Participants… | Phase 2 | terminated | Jun 22, 2010 | Agenus Inc. | Sponsor's business decision | Sponsor / business decision |
| NCT02693717 | Pemetrexed Disodium in Treating Patients With Previously Treated Metastatic Urothelial… | Phase 2 | terminated | Feb 29, 2016 | M.D. Anderson Cancer Center | The trial was closed due to the changing efficacy of treatments for metastatic urothelial cancer. | Efficacy / futility |
| NCT02581384 | Stereotactic Body Radiotherapy (SBRT) for Pulmonary Metastases in Ewing Sarcoma,… | Phase 1 / Phase 2 | terminated | Oct 21, 2015 | Dana-Farber Cancer Institute | The study closed primarily due to weak accrual, as well as study design limitations. | Enrollment / accrual |
| NCT01253668 | Brivanib Metastatic Renal Cell Carcinoma | Phase 2 | terminated | Dec 3, 2010 | Abramson Cancer Center at Penn Medicine | In November 2012, this study was permanently closed to new accrual at the request of the drug… | Drug supply |
| NCT03189186 | Phase-I Trial of Pembrolizumab and Percutaneous Cryoablation Combination Followed by… | Phase 1 | withdrawn | Jun 16, 2017 | University of California, Irvine | This study was closed due to extremely low accrual, as well as a change in care when using the… | Enrollment / accrual |
| NCT00324740 | Vorinostat and Isotretinoin in Treating Patients With Advanced Kidney Cancer | Phase 1 / Phase 2 | terminated | May 11, 2006 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT02495103 | Vandetanib in Combination With Metformin in People With HLRCC or SDH-Associated Kidney… | Phase 1 / Phase 2 | terminated | Jul 13, 2015 | National Cancer Institute (NCI) | Vandetanib is no longer available as Sanofi has decided not to provide additional drug. All… | Other (stated, no rule matched) |
| NCT02853162 | Ablative tReatment of Inoperable REnal Cell Carcinoma Using STereotactic Body…(ARREST) | Phase 2 | terminated | Aug 2, 2016 | UMC Utrecht | Slow inclusion | Other (stated, no rule matched) |
| NCT04609800 | Study on the Utilization of Cabozantinib in Adult Patients With Advanced or Metastatic…(CAROLINE) | — | withdrawn | Oct 30, 2020 | Ipsen | Unfavorable opinion of IRB/IEC | Other (stated, no rule matched) |
| NCT02947152 | HKT288 in Solid Tumors, Including Epithelial Ovarian Cancer and Renal Cell Carcinoma | Phase 1 | terminated | Oct 27, 2016 | Novartis Pharmaceuticals | not stated | Not stated |
| NCT02131376 | Investigating a Novel Modifiable Factor Affecting Renal Function After Partial… | N/A | terminated | May 6, 2014 | Indiana University | slow accrual, interim analysis showed no statistical significance | Efficacy / futility |
| NCT02071719 | Prediction of Response to Kinase Inhibitors Based on Protein Phosphorylation Profiles in… | — | terminated | Feb 26, 2014 | M. Labots | not stated | Not stated |
| NCT04262375 | A Phase 2 Study of Durvalumab (MEDI4736) and Oleclumab (MEDI9447) in Multi-Cancer…(DOMINATION) | Phase 2 | withdrawn | Feb 10, 2020 | University Health Network, Toronto | Overall clinical activity (ORR) for oleclumab + durvalumab is minimal across tumor types and does… | Other (stated, no rule matched) |
| NCT01673386 | A Subject Treatment Preference Study of Tivozanib Versus Sunitinib in Subjects With…(TAURUS) | Phase 2 | terminated | Aug 28, 2012 | AVEO Pharmaceuticals, Inc. | Sponsor | Other (stated, no rule matched) |
| NCT02595918 | Nivolumab in Treating Patients With High-Risk Kidney Cancer Before Surgery | Phase 1 | terminated | Nov 4, 2015 | National Cancer Institute (NCI) | Inadequate accrual rate | Enrollment / accrual |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Aug 15, 2022source: clinicaltrials