Clinical trial · Observational
Glycosylation of Exosomes in Prostate and Urothelial Carcinoma
NCT04960956CI-TRIAL-00057081terminatedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): Could not identify a replacement Principal Investigator.
Summary
Brief summary (as posted)
The purpose of this study is to collect a urine sample from patients with prostate and urothelial (bladder) cancer and healthy volunteers who do not have cancer, so that researchers can perform studies on microcellular structures called exosomes that may eventually lead to a new type of urinary biomarker test for prostate and urothelial cancer.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Prostate Cancer | Malignant Prostate Neoplasm | CURATED_EXACT | 0.92 |
| Urothelial Carcinoma | Urothelial Carcinoma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (0)
Data not yet available
No intervention recorded.
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- The concentration of urine spermine in the diagnosis of prostate and urothelial cancer
- timeFrame
- Baseline (one-time point)
- description
- xFresh urine will be collected for MALDI-TOF analysis to detect the concentration of exosome-derived glycans in the urine sample
Eligibility
Eligibility (as posted)
- Sex
- Male
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: 1. Males ≥ 18 years old at the time of informed consent 2. Ability to provide written informed consent and HIPAA authorization 3. Willingness to donate a fasting urine sample for research Patient Cohort 1. Histologically confirmed prostate or urothelial carcinoma 2. Localized disease 3. No neoadjuvant chemotherapy for disease Healthy Volunteer Cohort <!-- --> 1. Healthy volunteers must not have prostate or urothelial carcinoma Exclusion Criteria: 1. Concurrent disease or condition that would make the subject inappropriate for study participation or any serious medical or psychiatric disorder that would interfere with the subject's safety 2. Dementia, altered mental status, or any psychiatric condition that would prohibit the understanding or rendering of informed consent
References
Publications (0)
Data not yet available
No reference posted for this study.