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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
212 stopped studies mapped to Soft Tissue Sarcoma and descendants · 92% state a reason
Over the 212 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT03735758 | Quality of Life in Patients With Non-adipocyte Soft Tissue Sarcoma Under Palliative…(PazoQoL) | Phase 4 | terminated | Nov 8, 2018 | GWT-TUD GmbH | problems with recruiting | Enrollment / accrual |
| NCT02808247 | Ph II Nintedanib vs. Ifosfamide in Soft Tissue Sarcoma(ANITA) | Phase 2 | terminated | Jun 21, 2016 | European Organisation for Research and Treatment of Cancer - EORTC | Exceed of pre-specified number of failures in the experimental arm | Other (stated, no rule matched) |
| NCT04099277 | A Study of LY3435151 in Participants With Solid Tumors | Phase 1 | terminated | Sep 23, 2019 | Eli Lilly and Company | Study terminated due to strategic business decision by Eli Lilly and Company. | Sponsor / business decision |
| NCT04906876 | A Phase 2 Study of 9-ING-41Combined With Chemotherapy in Adolescents and Adults With… | Phase 2 | withdrawn | May 28, 2021 | Brown University | IND withdrawn | Other (stated, no rule matched) |
| NCT00232713 | Uterine Fibroid Pregnancy Registry | — | terminated | Oct 5, 2005 | Syneos Health | not stated | Not stated |
| NCT01034566 | Proton Beam Radiation Therapy in Treating Patients With Retroperitoneal Sarcoma | N/A | withdrawn | Dec 17, 2009 | Abramson Cancer Center at Penn Medicine | Failure to accrue | Enrollment / accrual |
| NCT02581384 | Stereotactic Body Radiotherapy (SBRT) for Pulmonary Metastases in Ewing Sarcoma,… | Phase 1 / Phase 2 | terminated | Oct 21, 2015 | Dana-Farber Cancer Institute | The study closed primarily due to weak accrual, as well as study design limitations. | Enrollment / accrual |
| NCT03902379 | Web-Based Coping and Communication Skills Intervention in Improving Psychological… | N/A | withdrawn | Apr 4, 2019 | Rutgers, The State University of New Jersey | The study was never initiated, no patients were enrolled. It has been closed with the IRB. | Enrollment / accrual |
| NCT03730077 | FMISO PET/CT Imaging Trial for Assessing Hypoxia in Soft Tissue Sarcomas | Phase 1 | terminated | Nov 5, 2018 | University of Pennsylvania | PI Left Institution | Investigator |
| NCT01543802 | Study of Preoperative Therapy With Pazopanib (Votrient®) to Treat High-risk Soft Tissue…(NOPASS) | Phase 2 | terminated | Mar 5, 2012 | Heidelberg University | slow recruitment | Enrollment / accrual |
| NCT03468075 | Gemcitabine Plus Ascorbate for Sarcoma in Adults | Phase 2 | terminated | Mar 16, 2018 | Mohammed Milhem, MBBS | Stopping rules met | Other (stated, no rule matched) |
| NCT03880123 | Selinexor in Combination With Ixazomib for the Treatment of Advanced Sarcoma | Phase 1 | withdrawn | Mar 19, 2019 | Matthew Ingham | Study will not proceed, no participants enrolled. | Enrollment / accrual |
| NCT01987596 | Study of Fixed vs. Flexible Filgrastim to Accelerate Bone Marrow Recovery After… | Phase 3 | terminated | Nov 19, 2013 | Barbara Ann Karmanos Cancer Institute | not stated | Not stated |
| NCT04567095 | A Study to Evaluate Awareness and Knowledge of the Fibristal Additional Risk Minimization… | — | withdrawn | Sep 28, 2020 | Allergan | This study was cancelled before any data collection due to business reasons. | Sponsor / business decision |
| NCT04567589 | A Study to Evaluate Awareness and Knowledge of the Fibristal Additional Risk Minimization… | — | withdrawn | Sep 28, 2020 | Allergan | This study was cancelled before any data collection due to business reasons. | Sponsor / business decision |
| NCT01663090 | Ferumoxytol-Enhanced MRI in Adult/Pedi Sarcomas | N/A | withdrawn | Aug 13, 2012 | Dana-Farber Cancer Institute | Inability to accrue. | Enrollment / accrual |
| NCT02425878 | Ulipristal Acetate 10 mg and Asisted Reproduction | Phase 3 | terminated | Apr 24, 2015 | Instituto Valenciano de Infertilidad, IVI VALENCIA | Lack of availibility of eligible subjects | Other (stated, no rule matched) |
| NCT02547376 | Genetic and Telomere Characteristics of High of Grade Soft Tissue Sarcomas | — | terminated | Sep 11, 2015 | University Hospitals, Leicester | Covid-19 | COVID-19 / pandemic |
| NCT03957096 | A Safety Study of SGN-CD47M in Patients With Solid Tumors | Phase 1 | terminated | May 21, 2019 | Seagen Inc. | Sponsor decision based on portfolio prioritization | Sponsor / business decision |
| NCT02929394 | Trabectedin Maintenance Post 1st-line in STS | Phase 3 | terminated | Oct 11, 2016 | European Organisation for Research and Treatment of Cancer - EORTC | Poor accrual | Enrollment / accrual |
| NCT01280045 | Influence of Aromatase Inhibitors and GnRH Analogs to Treat Uterine Leiomyoma by Vaginal… | N/A | terminated | Jan 20, 2011 | University of Sao Paulo | No grant was received then we stopped the recruitment | Enrollment / accrual |
| NCT01738724 | Study of the Efficacy of Dienogest in the Treatment of Uterine Leiomyomas When Compared… | Phase 4 | terminated | Nov 30, 2012 | University of Sao Paulo | PI went for a post-doc course and when he came back he moved for another job | Other (stated, no rule matched) |
| NCT03698227 | OlaReDo - Olaratumab and Rechallenge With Doxorubicin in Soft Tissue Sarcoma Patients | Phase 2 | terminated | Oct 5, 2018 | Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest | Lack of efficacy on olaratumab | Efficacy / futility |
| NCT02609984 | Study to Compare the Safety and Efficacy of CMB305 With Atezolizumab to Atezolizumab… | Phase 2 | terminated | Nov 20, 2015 | Immune Design, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) | This study did not meet the efficacy objective | Efficacy / futility |
| NCT03613259 | Fluorothymidine F-18 PET in Diagnosing Patients With Intermediate or High Grade Soft… | Early Phase 1 | withdrawn | Aug 3, 2018 | OHSU Knight Cancer Institute | Funding expired | Funding |
| NCT03104335 | Apatinib for Advanced Soft Tissue Sarcoma Patients: a Phase 2, Multicenter Trial | Phase 2 | withdrawn | Apr 7, 2017 | Peking University People's Hospital | Not enough patients | Other (stated, no rule matched) |
| NCT01533207 | Gemcitabine Hydrochloride and Docetaxel Followed by Doxorubicin Hydrochloride or… | Phase 3 | terminated | Feb 15, 2012 | Gynecologic Oncology Group | not stated | Not stated |
| NCT03520959 | A Phase 3, Randomized, Double-blind, Placebo-controlled Study For Subjects With… | Phase 3 | terminated | May 11, 2018 | Immune Design, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) | Study was terminated due to sponsor's decision. | Sponsor / business decision |
| NCT04132349 | Ulipristal Acetate in Symptomatic Uterine Fibroid | Phase 4 | terminated | Oct 18, 2019 | Mỹ Đức Hospital | Ulipristal Acetate was recalled | Other (stated, no rule matched) |
| NCT01392352 | HYPAZ: Hypertension Induced by Pazopanib(HYPAZ) | Phase 2 | terminated | Jul 12, 2011 | Cambridge University Hospitals NHS Foundation Trust | Following DMC review, due to slow recruitment of evaluable patients. | Enrollment / accrual |
| NCT03699176 | Assessment of Safety and Efficacy of Vilaprisan in Subjects With Uterine Fibroids(ASTEROID 7) | Phase 3 | withdrawn | Oct 9, 2018 | Bayer | No patient was recruited, study withdrawn for feasibility reasons. | Enrollment / accrual |
| NCT00287495 | BAY 43-9006 (Sorafenib) to Treat Patients With Kaposi's Sarcoma | Phase 1 | terminated | Feb 6, 2006 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00717522 | Efficacy and Safety Study of CC-4047 (Pomalidomide) to Treat Advanced Soft Tissue Sarcoma | Phase 2 | terminated | Jul 17, 2008 | Celgene | Study enrollment was terminated due to a corporate strategic decision unrelated to patient safety. | Safety / toxicity |
| NCT00859456 | Sunitinib in Certain Subtypes of Soft Tissue Sarcomas | Phase 2 | terminated | Mar 11, 2009 | Columbia University | Closed by pharmaceutical sponsor | Other (stated, no rule matched) |
| NCT02795819 | Study of the Pan-DAC Inhibitor AR-42 and Pazopanib in Advanced Sarcoma and Kidney Cancer | Phase 1 | terminated | Jun 10, 2016 | Virginia Commonwealth University | Study drug no longer being clinically developed by manufacturer | Drug supply |
| NCT03397186 | Immune Changes Following Trabectedin in Patients With Metastatic or Unresectable Sarcoma | Phase 2 | withdrawn | Jan 11, 2018 | Fred Hutchinson Cancer Center | Administrative | Other (stated, no rule matched) |
| NCT02683148 | DHEA in Synovial Sarcoma Patients | Phase 1 | terminated | Feb 17, 2016 | Washington University School of Medicine | The trial did not show any positive effects. | Other (stated, no rule matched) |
| NCT01834703 | Uterine Artery Embolization(UAE) Versus High-Intensity-Focused-Ultrasound(HIFU) for… | N/A | terminated | Apr 18, 2013 | Chinese University of Hong Kong | not stated | Not stated |
| NCT03210324 | A Study on the Mifepristone Tablets in the Treatment of Symptomatic Uterine Fibroids With… | Phase 4 | terminated | Jul 6, 2017 | China Resources Zizhu Pharmaceutical Co., Ltd. | It is difficult to recruit enough participants | Enrollment / accrual |
| NCT01957709 | Recombinant Interferon Gamma in Treating Patients With Soft Tissue Sarcoma | Early Phase 1 | terminated | Oct 8, 2013 | Fred Hutchinson Cancer Center | Enough samples were collected for data analysis. | Other (stated, no rule matched) |
| NCT02575066 | Clinical Study of Concurrent Pazopanib and Radiotherapy for Non-metastatic Sarcoma…(PASART-2) | Phase 2 | terminated | Oct 14, 2015 | The Netherlands Cancer Institute | stopping rule | Other (stated, no rule matched) |
| NCT02811159 | An Extension Study of 12 mg Proellex® (Telapristone Acetate) Administered Orally in the… | Phase 2 | terminated | Jun 23, 2016 | Repros Therapeutics Inc. | Business decision | Sponsor / business decision |
| NCT03773510 | Study on Leiomyosarcoma, Liposarcomas and Synovial Sarcoma With Trabectedin(TRADITIONS) | Phase 3 | withdrawn | Dec 12, 2018 | Italian Sarcoma Group | Not approved by the coordinating Ethical Committee | Other (stated, no rule matched) |
| NCT02879058 | Intraoperative Ultrasound in Laparoscopic or Robotic Myomectomy Patients | N/A | terminated | Aug 25, 2016 | The Cleveland Clinic | Due to inadequate enrollment. | Enrollment / accrual |
| NCT01752569 | A Study of Selumetinib in Patients With Kaposi's Sarcoma(SCART) | Phase 1 / Phase 2 | terminated | Dec 19, 2012 | Sheffield Teaching Hospitals NHS Foundation Trust | Poor recruitment | Enrollment / accrual |
| NCT02255110 | A Japanese Trial of TH-302 in Subjects With Locally Advanced Unresectable or Metastatic… | Phase 2 | terminated | Oct 2, 2014 | Merck KGaA, Darmstadt, Germany | Sponsor's decision due to negative result of Phase 3 study TH-CR-406/SARC021 | Sponsor / business decision |
| NCT00020683 | A Phase II Trial of COL-3 in Patients With HIV Related Kaposi's Sarcoma | Phase 2 | terminated | Jan 27, 2003 | National Cancer Institute (NCI) | Cancer Therapy Evaluation Program's (CTEP's) termination of drug supply | Drug supply |
| NCT02199938 | Identification and Characterization of Molecular Markers in Musculoskeletal Tumors | — | terminated | Jul 25, 2014 | Balgrist University Hospital | Principal Investigator has left the Institution | Investigator |
| NCT02775799 | National Swiss Sarcoma Cohort Study(SwissSARCOS) | — | terminated | May 18, 2016 | Balgrist University Hospital | Principal Investigator has left the Institution | Investigator |
| NCT00730886 | ExAblate Treatment of Uterine Fibroids for Fertility Enhancement | N/A | terminated | Aug 8, 2008 | InSightec | not stated | Not stated |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 22 days agoSource updated Sep 22, 2021source: clinicaltrials