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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
1,122 stopped studies mapped to Non-Small Cell Carcinoma and descendants · 90% state a reason
Over the 1,122 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT01913067 | Evaluation of Cabazitaxel in Patients With Brain Metastasis Secondary to Breast Cancer…(CRANIAL) | Phase 2 | withdrawn | Jul 31, 2013 | Jules Bordet Institute | Scientific rationale is deemed obsolete. Funders lost interest in the trial. | Other (stated, no rule matched) |
| NCT00545948 | Adjuvant Cisplatin With Either Genomic-Guided Vinorelbine or Pemetrexed for Early Stage…(TOP0703) | Phase 2 | terminated | Oct 18, 2007 | Duke University | Study terminated due to reproducibility issues with genomics prediction model. | Other (stated, no rule matched) |
| NCT01491633 | Dasatinib in Advanced Squamous Cell Lung Cancer | Phase 2 | terminated | Dec 14, 2011 | Dana-Farber Cancer Institute | Safety issues/concerns per DF/HCC PI | Safety / toxicity |
| NCT02157116 | Dose-Dense Induction/Neoadjuvant Chemotherapy in Locally Advanced Non-Small Cell Lung… | Phase 2 | terminated | Jun 5, 2014 | Duke University | Insufficient accrual to meet analysis goals | Enrollment / accrual |
| NCT00145418 | Oxaliplatin and Docetaxel as First-line Therapy for Advanced Non-small Cell Lung Cancer | Phase 2 | terminated | Sep 5, 2005 | Oncology Specialists, S.C. | low enrollment | Enrollment / accrual |
| NCT00907504 | Study Of The Effect Of CP-751,871 In Combination With Gemcitabine And Cisplatin In…(ADVIGO1017) | Phase 3 | withdrawn | May 22, 2009 | Pfizer | not stated | Not stated |
| NCT00976677 | Carboplatin, Paclitaxel, and Bevacizumab With or Without Erlotinib Hydrochloride in… | Phase 2 | terminated | Sep 14, 2009 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00614484 | Chemotherapy and Proton Radiation for the Treatment of Locally Advanced Lung Cancer | Phase 1 / Phase 2 | terminated | Feb 13, 2008 | Loma Linda University | Low participant enrollment rates. Significant comparative data not obtained. | Enrollment / accrual |
| NCT01471197 | Safety and Efficacy Trial of Ipilimumab Versus Pemetrexed in Non-Squamous Non-Small Cell… | Phase 2 | terminated | Nov 15, 2011 | Bristol-Myers Squibb | Administrative reasons | Other (stated, no rule matched) |
| NCT00088933 | Vaccine Therapy and Sargramostim With or Without Docetaxel in Treating Patients With… | Phase 1 | terminated | Aug 5, 2004 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00112060 | A Study to Assess the Safety and Preliminary Efficacy of PT-523 in Patients With Advanced… | Phase 1 / Phase 2 | withdrawn | May 30, 2005 | Spectrum Pharmaceuticals, Inc | not stated | Not stated |
| NCT00203931 | Trial Comparing Cetuximab With Pemetrexed/Cetuximab Therapy for Non-Small Cell Lung Cancer | Phase 2 | terminated | Sep 20, 2005 | University of Chicago | Slow accrual and evidence from other studies showing benefit of early initiation of pemetrexed… | Enrollment / accrual |
| NCT01409681 | A Multi-Centered Trial Evaluating the Role of Vitamin D Metabolism in Non-Small Cell Lung…(EBUS) | — | terminated | Aug 4, 2011 | University of Michigan Rogel Cancer Center | PI decided to terminate the study | Other (stated, no rule matched) |
| NCT01617980 | Multimodal Hypoxia Imaging and Intensity Modulated Radiotherapy for Inoperable…(HIL) | N/A | terminated | Jun 13, 2012 | German Cancer Research Center | Slow accrual | Enrollment / accrual |
| NCT01641575 | A Dose Ascending Study of Gemcitabine Elaidate (CO-101) in Combination With Cisplatin | Phase 1 | terminated | Jul 17, 2012 | Clovis Oncology, Inc. | Registrational study did not meet endpoint so entire program (including CO-101-011) was terminated. | Other (stated, no rule matched) |
| NCT00369551 | Bevacizumab, Paclitaxel, Carboplatin, and Radiation Therapy to the Chest in Treating… | Phase 1 | terminated | Aug 29, 2006 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT01256203 | Efficacy and Safety of a Sunscreen Against Porfimer Sodium-induced Phototoxicity to… | Phase 2 | withdrawn | Dec 8, 2010 | Pinnacle Biologics Inc. | Sponsor cancelled the study | Other (stated, no rule matched) |
| NCT00256841 | Hypo-Hyperfractionated Chest Radiation for Non Small Cell Lung Cancer With… | Phase 1 / Phase 2 | withdrawn | Nov 22, 2005 | Clinical Oncology Research Associates | Lack of funding | Funding |
| NCT01356368 | Customizing First Line Chemotherapy in Advanced Non-Small Cell Lung Cancer(Customizing) | Phase 2 | terminated | May 19, 2011 | National Guard Health Affairs | slow accrual rate | Enrollment / accrual |
| NCT01063478 | Dose Escalation Study of RAD001 in Combination w/Chemotherapy & Radiation in Patients…(RAD001) | Phase 1 | terminated | Feb 5, 2010 | University of Chicago | Poor accrual | Enrollment / accrual |
| NCT00265603 | Safety Study: Combined Modality Treatment for Non-Small Cell Lung Cancer | Phase 1 | terminated | Dec 15, 2005 | Atlantic Health System | not stated | Not stated |
| NCT01473693 | Changes in Brain Structure Related to Systemic Chemotherapy Treatment: A Prospective… | — | terminated | Nov 17, 2011 | Memorial Sloan Kettering Cancer Center | Lack of Accrual | Enrollment / accrual |
| NCT01640730 | Safety and Exploratory Efficacy of Kanglaite Injection in Non Small Cell Lung Cancer | Phase 2 | terminated | Jul 16, 2012 | KangLaiTe USA | poor enrollment | Enrollment / accrual |
| NCT01637376 | Photodynamic Therapy (PDT) With Temoporfin for Non-Resectable Non-Small-Cell Lung Cancer | Phase 1 | withdrawn | Jul 11, 2012 | University of Arkansas | No participants were enrolled | Enrollment / accrual |
| NCT00596830 | Carboplatin And Paclitaxel With Or Without CP-751, 871 (An IGF-1R Inhibitor) For Advanced… | Phase 3 | terminated | Jan 17, 2008 | Pfizer | See termination reason in detailed description. | Other (stated, no rule matched) |
| NCT01871480 | CIK Cell Transfusion Plus Gefitinib As Second Or Third-Line Treatment for Advanced… | Phase 2 | terminated | Jun 6, 2013 | Kunming Medical University | not stated | Not stated |
| NCT00558636 | A Trial Comparing Safety and Efficacy of Carboplatin and Paclitaxel Plus or Minus… | Phase 3 | terminated | Nov 15, 2007 | Bayer | Terminated early when the results from Study NCT00300885 showed an overall lack of efficacy in… | Efficacy / futility |
| NCT01836341 | Afatinib In Combination With Cisplatin Or Carboplatin + Pemetrexed In Patients With… | Phase 1 | withdrawn | Apr 19, 2013 | Memorial Sloan Kettering Cancer Center | not stated | Not stated |
| NCT01533727 | CIK Cell Transfusion Plus Chemotherapy as Adjuvant Therapy for Stage IB-IIIA Non-Small… | Phase 2 | withdrawn | Feb 15, 2012 | Sun Yat-sen University | Few patients would like to participate ,since CIK cell transfusion was a new treatment and its… | Efficacy / futility |
| NCT00887315 | The Synergistic Metastases Annihilation With Radiotherapy and Docetaxel (Taxotere)…(SMART) | Phase 2 | terminated | Apr 23, 2009 | University of Chicago | Slow accrual and loss of sponsor | Enrollment / accrual |
| NCT00701870 | Study of Telintra for Treatment of Chemotherapy Induced Neutropenia in Patients With… | Phase 2 | terminated | Jun 19, 2008 | Telik | Study TLK199.2102 was terminated for lack of enrollment. | Enrollment / accrual |
| NCT01504542 | Immune Response and Safety of HS110 Vaccine in Combination With Erlotinib in Patients… | Phase 2 | withdrawn | Jan 5, 2012 | Heat Biologics | Lack of enrollment | Enrollment / accrual |
| NCT00365183 | Trial of Motexafin Gadolinium and Pemetrexed (Alimta®) for Second Line Treatment in… | Phase 2 | terminated | Aug 17, 2006 | Pharmacyclics LLC. | not stated | Not stated |
| NCT01060514 | Pazopanib + Vinorelbine in Non Small Cell Lung Cancer (NSCLC) and Breast Cancer | Phase 1 | terminated | Feb 2, 2010 | Northwestern University | Lack of timely accrual. | Enrollment / accrual |
| NCT01674738 | TS Stratified Chemotherapy and VEGF Inhibition in Non-Squamous Non-Small Cell Lung Cancer…(SELECT-A) | Phase 2 | withdrawn | Aug 29, 2012 | Aktion Bronchialkarzinom e.V. | Decision of the Sponsor, as the funding of the study was no longer guaranteed. | Funding |
| NCT00536107 | Study to Assess Safety/Tolerability/Efficacy of Gefitinib Versus Docetaxel in Locally… | Phase 4 | terminated | Sep 27, 2007 | AstraZeneca | not stated | Not stated |
| NCT01728181 | A Phase I/II Study of Tivozanib and Erlotinib as Initial Treatment for Metastatic… | Phase 1 / Phase 2 | withdrawn | Nov 16, 2012 | University of Utah | Stopped before approval due to ineffective drug | Other (stated, no rule matched) |
| NCT00673049 | Trial Of CP-751, 871 And Erlotinib In Refractory Lung Cancer(NSCLC) | Phase 3 | terminated | May 7, 2008 | Pfizer | See termination reason in detailed description. | Other (stated, no rule matched) |
| NCT01006226 | 64CuATSM and Hypoxia in Stage IV Non-small Cell Lung Cancer With Carboplatin, Paclitaxel,… | N/A | withdrawn | Nov 2, 2009 | Washington University School of Medicine | Withdrawn due to funding issues | Funding |
| NCT01282333 | Veliparib, Cisplatin, and Gemcitabine Hydrochloride in Treating Patients With Advanced… | Phase 1 | terminated | Jan 25, 2011 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT01337154 | First Line Study of Tamibarotene in Combination for Advanced Non-Small Cell Lung Cancer | Phase 2 | terminated | Apr 18, 2011 | CytRx | Interim analysis showed that the primary endpoint would not be met. | Efficacy / futility |
| NCT00773383 | A Study of the Effect of R1507 in Combination With Tarceva (Erlotinib) on… | Phase 2 | terminated | Oct 16, 2008 | Hoffmann-La Roche | not stated | Not stated |
| NCT00087269 | Erlotinib in Treating Patients With Stage I-IIIA Non-Small Cell Lung Cancer Undergoing… | Phase 2 | terminated | Jul 12, 2004 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00758134 | Trastuzumab Therapy in Non-Small Cell Lung Cancer Patients | Phase 2 | terminated | Sep 23, 2008 | Armando Santoro, MD | Insufficient accrual | Enrollment / accrual |
| NCT00268255 | Gefitinib and Radiation Therapy in Treating Patients With Inoperable Stage I or Stage II… | Phase 1 / Phase 2 | withdrawn | Dec 22, 2005 | Barbara Ann Karmanos Cancer Institute | Study never moved forward with accrual. | Enrollment / accrual |
| NCT01088620 | Panitumumab Plus Pemetrexed and Cisplatin (PemCisP) Versus PemCis in the First-line… | Phase 2 | suspended | Mar 17, 2010 | WiSP Wissenschaftlicher Service Pharma GmbH | the DSMB stopped the trial due to unacceptable side effects in the experimental arm which has not… | Other (stated, no rule matched) |
| NCT00937482 | Cediranib Maleate and Whole Brain Radiation Therapy in Patients With Brain Metastases… | Phase 1 | terminated | Jul 13, 2009 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT01500824 | A Clinical Study Testing The Safety And Efficacy Of Crizotinib In East Asian Patients… | Phase 2 | withdrawn | Dec 28, 2011 | Pfizer | not stated | Not stated |
| NCT00705549 | Individualized Therapy Based of Tumoral mRNA Levels of ERCC1, RRM1 and BRCA1 in Advanced… | Phase 2 | terminated | Jun 26, 2008 | Hellenic Oncology Research Group | Due to poor accrual | Enrollment / accrual |
| NCT00042835 | Erlotinib and Radiation Therapy Plus Combination Chemotherapy in Treating Patients With… | Phase 1 | terminated | Jan 27, 2003 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Jul 24, 2014source: clinicaltrials