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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
192 stopped studies mapped to Malignant Uterine Corpus Neoplasm and descendants · 87% state a reason
Over the 192 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computed
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT00883116 | A Study of Ixabepilone as Second-line Therapy for Locally Advanced, Recurrent, or…(IXAMPLE2) | Phase 3 | terminated | Apr 17, 2009 | R-Pharm | Interim analysis results showed that ixabepilone did not improve survival compared with control… | Efficacy / futility |
| NCT01971060 | a Study to Evaluate Adhesion Risk in Fertility Patients' Status Post Laparoscopic…(VLocmyo) | N/A | withdrawn | Oct 28, 2013 | The Advanced Gynecologic Surgery Institute | lack of funding | Funding |
| NCT01061606 | Temsirolimus in Treating Patients With Recurrent or Persistent Cancer of the Uterus | Phase 2 | terminated | Feb 3, 2010 | National Cancer Institute (NCI) | Poor accrual | Enrollment / accrual |
| NCT02042495 | Endometrial Cancer Biomarker Changes Following Exposure to Metformin | Phase 2 | withdrawn | Jan 23, 2014 | Jewish General Hospital | Did not obtain Health Canda approval for drug use in reasonable time and moved onward to new trial | Other (stated, no rule matched) |
| NCT01555073 | Preemptive Analgesia Following Uterine Artery Embolization | Phase 4 | terminated | Mar 15, 2012 | Northwestern University | Subjects did not meet inclusion criteria | Other (stated, no rule matched) |
| NCT00671606 | Hysteroscopic Lymphatic Mapping for Endometrial Cancer | Phase 2 | terminated | May 5, 2008 | M.D. Anderson Cancer Center | Slow accrual. | Enrollment / accrual |
| NCT01675011 | Embozene Microspheres for Uterine Fibroid Embolization (UFE) | N/A | terminated | Aug 29, 2012 | Boston Scientific Corporation | Inadequate enrollment | Enrollment / accrual |
| NCT02042885 | A Clinical Trial to Determine the Most Suitable Dose of OPB-111001 in Patients With… | Phase 1 / Phase 2 | terminated | Jan 23, 2014 | Otsuka Novel Products GmbH | not stated | Not stated |
| NCT00471120 | Feasibility Study: Accuracy of Biomarker in Detection of Endometrial Cancer | N/A | terminated | May 9, 2007 | Dick Domanik | Study terminated due to protocol deficiencies. | Other (stated, no rule matched) |
| NCT01401829 | Psychosocial Benefits of Exercise in Endometrial Cancer Survivors | Phase 1 | terminated | Jul 25, 2011 | University of Alabama at Birmingham | Terminated due to lack of funding required to continue the study. | Funding |
| NCT01226290 | Fibroid Ablation Study(FAST-EU) | N/A | terminated | Oct 22, 2010 | Gynesonics | Investigational device changes; adequate enrollment achieved | Enrollment / accrual |
| NCT01539187 | Fibroid Ablation Study - Large Fibroids(FAST-L) | N/A | terminated | Feb 27, 2012 | Gynesonics | Investigational device changes | Other (stated, no rule matched) |
| NCT01998854 | Observational Prospective Study on Patients With Symptomatic Uterine Fibroids Treated… | — | terminated | Dec 2, 2013 | Gynesonics | Investigational device changes | Other (stated, no rule matched) |
| NCT01943058 | Megestrol Acetate or Levonorgestrel-Releasing Intrauterine System in Treating Patients… | Phase 2 | withdrawn | Sep 16, 2013 | University of Southern California | Lack of funding | Funding |
| NCT01786226 | Mifepristone to Treat Uterine Fibroids | Phase 2 / Phase 3 | terminated | Feb 7, 2013 | Mediterranea Medica S. L. | not stated | Not stated |
| NCT00958893 | An Extension Study Evaluating Safety and Efficacy of Proellex® In Women Who Have… | Phase 2 | terminated | Aug 13, 2009 | Repros Therapeutics Inc. | Repros stopped the study for safety and FDA put the study on hold for safety. | Safety / toxicity |
| NCT00470067 | Doxorubicin Hydrochloride Liposome and Carboplatin in Treating Patients With Recurrent,… | Phase 2 | terminated | May 7, 2007 | Roswell Park Cancer Institute | Due to low accrual | Enrollment / accrual |
| NCT00683917 | Pharmacokinetics, Safety and Efficacy Study of Proellex in Pre-menopausal Women With… | Phase 2 | terminated | May 26, 2008 | Repros Therapeutics Inc. | Repros stopped the study for safety and FDA put the study on hold for safety. | Safety / toxicity |
| NCT00702702 | Safety and Efficacy of Proellex in Pre-menopausal Anemic Women With Symptomatic Uterine… | Phase 3 | terminated | Jun 20, 2008 | Repros Therapeutics Inc. | Repros stopped study for safety and FDA put study on hold because of safety. | Safety / toxicity |
| NCT00735553 | Evaluating the Safety and Efficacy of Proellex® (CDB-4124) in Premenopausal Women With… | Phase 3 | terminated | Aug 15, 2008 | Repros Therapeutics Inc. | Repros stopped the study for safety and FDA put the study on hold for safety. | Safety / toxicity |
| NCT00737282 | Multicenter Study Evaluating the Safety of Proellex® in Premenopausal Women With Uterine… | Phase 3 | terminated | Aug 18, 2008 | Repros Therapeutics Inc. | Repros stopped study for safety and FDA put study on hold. | Safety / toxicity |
| NCT00785356 | Safety and Efficacy of Proellex in Pre-Menopausal Anemic Women With Symptomatic Uterine… | Phase 3 | terminated | Nov 5, 2008 | Repros Therapeutics Inc. | Repros stopped the study for safety and FDA put the study on hold for safety. | Safety / toxicity |
| NCT00853567 | Evaluating the Safety and Efficacy of Proellex® in Premenopausal Women With Symptomatic… | Phase 3 | terminated | Mar 2, 2009 | Repros Therapeutics Inc. | Repros stopped the study for safety and FDA put the study on hold for safety. | Safety / toxicity |
| NCT01069120 | Safety of 25 and 50 mg Proellex® in the Treatment of Women With Symptomatic Uterine… | Phase 3 | terminated | Feb 17, 2010 | Repros Therapeutics Inc. | Repros stopped study due to safety and FDA placed study on hold | Safety / toxicity |
| NCT01550380 | BKM120 in Advanced, Metastatic, or Recurrent Endometrial Cancers(BKM120) | Phase 2 | withdrawn | Mar 12, 2012 | University of Utah | not stated | Not stated |
| NCT00874302 | Safety and Efficacy of 25 and 50 mg Doses of Proellex® in Treating the Recurrence of… | Phase 3 | withdrawn | Apr 2, 2009 | Repros Therapeutics Inc. | Study terminated for safety and the FDA put the study on hold for safety. | Safety / toxicity |
| NCT00768742 | Safety and Effectiveness Study of RF Ablation of Uterine Fibroids to Reduce Menstrual…(FAST) | N/A | withdrawn | Oct 8, 2008 | Gynesonics | study revised and reinitiated under another protocol | Other (stated, no rule matched) |
| NCT01498237 | Photoacoustic Endoscopy in Endometrial Cancer | Early Phase 1 | withdrawn | Dec 23, 2011 | Washington University School of Medicine | Need to obtain IDE prior to commencement of study | Other (stated, no rule matched) |
| NCT00566644 | Intrauterine Levonorgestrel and Observation or Observation Alone in Preventing Atypical… | Phase 3 | terminated | Dec 3, 2007 | St George's, University of London | Withdrawn due to poor accrual | Enrollment / accrual |
| NCT00003179 | Surgery Plus Medroxyprogesterone in Preventing Endometrial Cancer | Phase 2 | terminated | Jan 27, 2003 | Gynecologic Oncology Group | not stated | Not stated |
| NCT00002976 | Estrogen Replacement Therapy in Treating Women With Early-Stage Endometrial Cancer | Phase 3 | terminated | Jan 27, 2003 | Gynecologic Oncology Group | not stated | Not stated |
| NCT00003624 | Amifostine in Treating Women With Ovarian, Peritoneal, Cervical, Fallopian Tube, Uterine,… | Phase 2 | terminated | Jun 16, 2004 | Gynecologic Oncology Group | not stated | Not stated |
| NCT00016341 | Combination Chemotherapy Compared With Hormone Therapy in Treating Patients With… | Phase 3 | terminated | Sep 9, 2003 | Gynecologic Oncology Group | not stated | Not stated |
| NCT00087191 | EF5 and Motexafin Lutetium in Detecting Tumor Cells in Patients With Abdominal or… | N/A | terminated | Jul 12, 2004 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00669422 | ChemoFx® PRO - A Post-Market Data Collection Study | — | terminated | Apr 30, 2008 | Precision Therapeutics | not stated | Not stated |
| NCT00496080 | Doppler-Guided Uterine Artery Occlusion (DUAO) Device for Fibroid Related Bleeding(DUAO) | N/A | terminated | Jul 4, 2007 | Ethicon, Inc. | Trial terminated early due to results from a similar study. | Other (stated, no rule matched) |
| NCT01290406 | BEZ235 Trial in Patients With Advanced Endometrial Carcinoma | Phase 2 | withdrawn | Feb 7, 2011 | Novartis Pharmaceuticals | not stated | Not stated |
| NCT00118300 | Capecitabine and Radiation Therapy in Treating Patients With Locally Advanced Cervical… | Phase 1 | withdrawn | Jul 11, 2005 | Case Comprehensive Cancer Center | Competing studies | Other (stated, no rule matched) |
| NCT00496067 | Uterine Artery Occlusion for Fibroid Related Bleeding | N/A | terminated | Jul 4, 2007 | Ethicon, Inc. | Data required further pilot work to be undertaken. | Other (stated, no rule matched) |
| NCT01140555 | A Pilot Study to Determine Optimal Procedure Steps to Obtain and Maintain Uterine Artery… | N/A | terminated | Jun 9, 2010 | Ethicon, Inc. | Further internal evaluation of the device was required. | Other (stated, no rule matched) |
| NCT00161226 | A Randomized, Controlled, Comparative Study of a Levonorgestrel Intrauterine System for… | — | terminated | Sep 12, 2005 | University of Medicine and Dentistry of New Jersey | Principal investigator left institution | Investigator |
| NCT00584207 | Radiofrequency Ablation of Uterine Fibroids | Early Phase 1 | terminated | Jan 2, 2008 | University of California, Davis | Unsufficient referrals for recruitment | Enrollment / accrual |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 22 days agoSource updated Mar 9, 2017source: clinicaltrials