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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
1,685 stopped studies mapped to Malignant Thoracic Neoplasm and descendants · 90% state a reason
Over the 1,685 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT00977561 | A Study Of Cisplatin (Or Carboplatin) And Etoposide With Or Without Figitumumab… | Phase 2 | terminated | Sep 15, 2009 | Pfizer | See termination reason in detailed description. | Other (stated, no rule matched) |
| NCT01500824 | A Clinical Study Testing The Safety And Efficacy Of Crizotinib In East Asian Patients… | Phase 2 | withdrawn | Dec 28, 2011 | Pfizer | not stated | Not stated |
| NCT00014196 | S0022:Combination Chemotherapy and Radiation Therapy in Treating Patients With Stage IIIB… | Phase 2 | terminated | Jan 27, 2003 | SWOG Cancer Research Network | This study was closed early due to poor accrual. | Enrollment / accrual |
| NCT00705549 | Individualized Therapy Based of Tumoral mRNA Levels of ERCC1, RRM1 and BRCA1 in Advanced… | Phase 2 | terminated | Jun 26, 2008 | Hellenic Oncology Research Group | Due to poor accrual | Enrollment / accrual |
| NCT00042835 | Erlotinib and Radiation Therapy Plus Combination Chemotherapy in Treating Patients With… | Phase 1 | terminated | Jan 27, 2003 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT01039311 | Optical Coherence Tomography: An Adjunct to Flexible Bronchoscopy in the Diagnosis of…(OCT) | — | terminated | Dec 24, 2009 | University of Oklahoma | Unable to enroll subjects | Enrollment / accrual |
| NCT00090675 | Maintenance ZD1839 (IRESSA®) Following Completion of Front Line, Platinum-Based, Double…(IMAC/Herbst) | Phase 3 | withdrawn | Sep 3, 2004 | AstraZeneca | No patients randomised | Other (stated, no rule matched) |
| NCT00776295 | Autologous SCT Followed by Dendritic Cell p53 Vaccination in Patients With Limited Stage… | Phase 2 | terminated | Oct 21, 2008 | H. Lee Moffitt Cancer Center and Research Institute | Low accrual | Enrollment / accrual |
| NCT00040768 | Bortezomib in Treating Patients With Advanced Non-small Cell Lung Cancer | Phase 2 | terminated | Jan 27, 2003 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00087191 | EF5 and Motexafin Lutetium in Detecting Tumor Cells in Patients With Abdominal or… | N/A | terminated | Jul 12, 2004 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00862134 | Randomized, Multi-center, Open-label, Study of PR104 Versus PR104/Docetaxel in Non-Small… | Phase 2 | terminated | Mar 16, 2009 | Proacta, Incorporated | Interim analysis indicated low probability of clinically significant result | Efficacy / futility |
| NCT00288054 | S0429: Docetaxel, Cetuximab, and Radiation Therapy in Treating Patients With Stage III… | Phase 1 | terminated | Feb 7, 2006 | SWOG Cancer Research Network | Study closed early due to poor accrual. | Enrollment / accrual |
| NCT00288444 | Interaction of Docetaxel and Lonafarnib in Patients With Advanced Cancer | Phase 1 | terminated | Feb 8, 2006 | Emory University | not stated | Not stated |
| NCT00544674 | PR104 in Treating Patients With Previously Untreated or Relapsed Small Cell Lung Cancer | Phase 2 | terminated | Oct 16, 2007 | Proacta, Incorporated | Terminated early due to discovery of new mechanism of activation. | Other (stated, no rule matched) |
| NCT01071434 | Feasibility of Using Real-time Cine-MRI for Treating Moving & Deforming Tumors | — | terminated | Feb 19, 2010 | Stanford University | PI left | Investigator |
| NCT00527982 | Celecoxib as Adjuvant Biologic Therapy in Patients With Head and Neck and Lung Cancer | Phase 2 | terminated | Sep 11, 2007 | M.D. Anderson Cancer Center | Termination due to poor accrual. | Enrollment / accrual |
| NCT01004510 | Zometa Adjuvant Treatment of Malignant Pleural Effusion Due To Non-Small Cell Lung Cancer(ZAP) | Phase 2 | terminated | Oct 30, 2009 | Peter Bushunow MD | failure to accrue projected number of patients | Enrollment / accrual |
| NCT00387348 | Escitalopram in Treating Depression in Patients With Advanced Lung or Gastrointestinal… | Phase 3 | terminated | Oct 13, 2006 | Massachusetts General Hospital | DSMB stopped study because placebo arm had more adverse events | Safety / toxicity |
| NCT01077492 | Virtual Bronchoscopy Transbronchial Needle Aspiration(TBNA): a Proof of Concept Study | — | terminated | Mar 1, 2010 | Amsterdam UMC, location VUmc | not stated | Not stated |
| NCT00090961 | S0229, Pulmonary Rehabilitation Education w/wo Exercise Training in Improving Physical… | N/A | terminated | Sep 8, 2004 | SWOG Cancer Research Network | Closed early due to poor accrual. | Enrollment / accrual |
| NCT00265785 | S0526: Pemetrexed Disodium in Treating Patients With Stage III or Stage IV Non-Small Cell… | Phase 2 | terminated | Dec 15, 2005 | SWOG Cancer Research Network | Closed due to poor accrual | Enrollment / accrual |
| NCT00104728 | Neoadjuvant IRESSA As Single Agent PreopTherapy for NSCLC With Molecular Correlates | N/A | terminated | Mar 4, 2005 | H. Lee Moffitt Cancer Center and Research Institute | Early Stopping Rule: Would not meet interim analysis goal to proceed with enrollment | Efficacy / futility |
| NCT01124812 | 131I-L19SIP Radioimmunotherapy Combined With Radiochemotherapy in Patients With… | Phase 1 | terminated | May 17, 2010 | Philogen S.p.A. | not stated | Not stated |
| NCT00098462 | Gefitinib and Sirolimus in Treating Patients With Recurrent or Refractory Stage IIIB or… | Phase 1 / Phase 2 | withdrawn | Dec 8, 2004 | Jonsson Comprehensive Cancer Center | Withdrawn as study never opened | Other (stated, no rule matched) |
| NCT00738335 | Stereotactic Radiosurgery and Erlotinib in Treating Patients With Non-Small Cell Lung… | Phase 1 | withdrawn | Aug 20, 2008 | University of California, San Francisco | not stated | Not stated |
| NCT00062335 | High-Dose 3-Dimensional Conformal Radiation Therapy in Treating Patients With Inoperable… | Phase 1 | terminated | Jun 6, 2003 | European Organisation for Research and Treatment of Cancer - EORTC | low accrual | Enrollment / accrual |
| NCT00664105 | Ph II Concurrent Chemo t/Docetaxel/Carboplatin/Radio Therapy-consolidation t/Locally Adv… | Phase 2 | terminated | Apr 22, 2008 | Vanderbilt-Ingram Cancer Center | Treatment became standard. | Other (stated, no rule matched) |
| NCT00694603 | Cetuximab as Therapy for Recurrent Non-Small Cell Lung Cancer Patients Who Have Received… | Phase 2 | terminated | Jun 10, 2008 | Lecia V. Sequist | Slow accrual | Enrollment / accrual |
| NCT01416961 | Integration of Neutron Therapy in the Treatment Plan for Stage III Non-Small Cell Lung… | Phase 1 | withdrawn | Aug 15, 2011 | Barbara Ann Karmanos Cancer Institute | Neutron therapy has become unavailable | Other (stated, no rule matched) |
| NCT00093132 | Satraplatin for Locally Advanced Non-Small Cell Lung Cancer With Simultaneous Radiotherapy | Phase 1 / Phase 2 | terminated | Oct 4, 2004 | Agennix | Sponsor decided to discontinue study drug development. | Sponsor / business decision |
| NCT01563601 | Efficacy and Safety of Obatoclax Mesylate in Combination With Carboplatin and Etoposide… | Phase 3 | withdrawn | Mar 27, 2012 | Cephalon | Business Decision | Sponsor / business decision |
| NCT00386555 | A Phase 2 Study in Patients With Advanced Non-Small Cell Lung Cancer Using New Agents… | Phase 2 | withdrawn | Oct 11, 2006 | Arog Pharmaceuticals, Inc. | Study was cancelled before patient enrollment | Enrollment / accrual |
| NCT00048087 | Iressa/Docetaxel in Non-Small-Cell Lung Cancer | Phase 2 | withdrawn | Oct 25, 2002 | M.D. Anderson Cancer Center | Slow accrual. | Enrollment / accrual |
| NCT01373463 | Cisplatin and Pemetrexed With Radiation Followed by Lobectomy(CisPemXetSrg) | Phase 1 | terminated | Jun 15, 2011 | Medical University of South Carolina | Investigator left site | Investigator |
| NCT00074295 | S0310: Vaccine Therapy in Treating Patients With Stage IIIB or Stage IV Bronchoalveolar… | Phase 2 | terminated | Dec 11, 2003 | SWOG Cancer Research Network | closed due to lack of availability of vaccine | Other (stated, no rule matched) |
| NCT00003803 | Chemotherapy Plus Radiation Therapy in Treating Patients With Stage I, Stage II, or Stage… | Phase 3 | terminated | Jan 27, 2003 | European Organisation for Research and Treatment of Cancer - EORTC | low accrual | Enrollment / accrual |
| NCT00021112 | Combination Chemotherapy Plus Radiation Therapy Followed by Surgery in Treating Patients… | Phase 2 | terminated | Jan 27, 2003 | European Organisation for Research and Treatment of Cancer - EORTC | low accrual | Enrollment / accrual |
| NCT00389688 | Pemetrexed Disodium and Cisplatin Before or After Surgery in Treating Patients With Stage… | Phase 2 | terminated | Oct 19, 2006 | European Organisation for Research and Treatment of Cancer - EORTC | low accrual | Enrollment / accrual |
| NCT00091156 | Gefitinib After Chemotherapy in Treating Patients With Stage IIIB or Stage IV Non-Small… | Phase 3 | terminated | Sep 8, 2004 | European Organisation for Research and Treatment of Cancer - EORTC | low accrual | Enrollment / accrual |
| NCT00003985 | KRN7000 in Treating Patients With Solid Tumors | Phase 1 | withdrawn | May 25, 2004 | European Organisation for Research and Treatment of Cancer - EORTC | not stated | Not stated |
| NCT00334763 | Radiation Therapy, Chemotherapy, and Bevacizumab in Treating Patients With Recurrent,… | Phase 2 | terminated | Jun 8, 2006 | Northwestern University | Principal Investigator felt risk to patients was too high. | Investigator |
| NCT00822016 | Observational Study of Best Supportive Care With or Without Surgery, Chemo or… | — | terminated | Jan 14, 2009 | New Mexico Cancer Research Alliance | PI left institution. Insufficient enrollment for analysis. | Investigator |
| NCT01314677 | Fludeoxyglucose F 18 PET/CT Scans in Predicting Therapy Response in Patients With Stage… | N/A | withdrawn | Mar 14, 2011 | City of Hope Medical Center | No subjects have been accrued to this trial. The PI will no longer be at COH and requests a study… | Enrollment / accrual |
| NCT00522938 | Clinical Trial of the Safety and Effectiveness of CHR-2797 With Erlotinib in Patients… | Phase 1 / Phase 2 | terminated | Aug 30, 2007 | Chroma Therapeutics | Very poor recruitment of patients to the study | Enrollment / accrual |
| NCT00442026 | Randomized Trial of Docetaxel and Gemcitabine Versus Gemcitabine in Elderly Patients With… | Phase 3 | terminated | Mar 1, 2007 | Hellenic Oncology Research Group | Due to poor accrual | Enrollment / accrual |
| NCT00127387 | Enbrel Versus Placebo With Radiation Therapy to Combat Fatigue and Cachexia | Phase 2 / Phase 3 | terminated | Aug 5, 2005 | The University of Texas Health Science Center at San Antonio | PI moved to Oregon | Other (stated, no rule matched) |
| NCT00971191 | A Study In Patients Who Will Undergo Surgical Removal Of Non-Small Cell Lung Cancer To… | Phase 1 | terminated | Sep 3, 2009 | Pfizer | See termination reason in detailed description. | Other (stated, no rule matched) |
| NCT01203579 | Chest Computed Tomography (CT) Screening Study With Antibody Testing | — | withdrawn | Sep 16, 2010 | Mayo Clinic | Due to lack of funding | Funding |
| NCT00045617 | S0122: Combination Chemotherapy, Radiation Therapy, and Vaccine Therapy in Limited-Stage… | Phase 2 | terminated | Jan 27, 2003 | SWOG Cancer Research Network | Closed due to lack of drug availability. | Drug supply |
| NCT00004093 | Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Stage III… | Phase 1 / Phase 2 | terminated | Nov 4, 2003 | Northwestern University | Original Principal Investigator left the institution. | Investigator |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Feb 25, 2013source: clinicaltrials