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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
1,672 stopped studies mapped to Malignant Reproductive System Neoplasm and descendants · 89% state a reason
Over the 1,672 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT01950871 | Prostate Guided Biopsy Study Evaluating the Diagnostic Performance of Prostate…(PHSTT-01) | Phase 4 | terminated | Sep 26, 2013 | Advanced Medical Diagnostics s.a. | Sponsor is bankrupt | Other (stated, no rule matched) |
| NCT01492920 | Acetyl-L-Carnitine Hydrochloride in Preventing Peripheral Neuropathy in Patients With… | Phase 3 | withdrawn | Dec 15, 2011 | Gynecologic Oncology Group | Withdrawn | Other (stated, no rule matched) |
| NCT01927393 | Palliative Care in Improving Quality of Life and Symptoms in Patients With Stage III-IV… | N/A | withdrawn | Aug 22, 2013 | City of Hope Medical Center | Study was not funded | Funding |
| NCT01777230 | The Value of Preoperative Sentinel Lymph Node Mapping by Pelvic MR Lymphangiography and… | — | withdrawn | Jan 28, 2013 | UMC Utrecht | Unable to get required research materials | Other (stated, no rule matched) |
| NCT01838265 | Trial of Prostate Cancer Patients Undergoing Active Surveillance With or Without…(MGM) | — | withdrawn | Apr 24, 2013 | University of Miami | Unlikely to Accrue | Enrollment / accrual |
| NCT01747239 | Cabazitaxel in Platinum Refractory Ovarian Cancer | Phase 2 | terminated | Dec 11, 2012 | Vejle Hospital | Too low inclusion rate. Only 4 patients included over 16 months | Other (stated, no rule matched) |
| NCT01469338 | Cabazitaxel Plus Prednisone With Octreotide For Castration-Resistant Prostate Cancer… | Phase 2 | terminated | Nov 10, 2011 | University of Southern California | lack of funding | Funding |
| NCT00787488 | Pilot Study of IV and IP Chemotherapy Plus Abdominal Hyperthermia for Ovarian Ca | N/A | withdrawn | Nov 7, 2008 | Mark Dewhirst | Study not funded | Funding |
| NCT01531205 | Neoadjuvant Chemohormonal Therapy Followed by Salvage Surgery for High Risk PSA | Phase 2 | terminated | Feb 10, 2012 | H. Lee Moffitt Cancer Center and Research Institute | low accrual | Enrollment / accrual |
| NCT00753220 | Safety Study of Autologous Dendritic Cells Injected Into the Prostate After Cryoablation…(CRITICAL) | Phase 1 / Phase 2 | terminated | Sep 16, 2008 | Bostwick Laboratories | Withdrew the IND with the FDA. | Other (stated, no rule matched) |
| NCT00918385 | Genomic Guided Therapy With Dasatinib or Nilutamide in Metastatic Castration-Resistant…(ARS) | Phase 2 | terminated | Jun 11, 2009 | Duke University | Permanent closure of trial to further accrual based on IDE disapproval | Enrollment / accrual |
| NCT01320787 | 18-F-Fluoroacetate as PET Imaging Agent | Phase 1 | withdrawn | Mar 22, 2011 | M.D. Anderson Cancer Center | not stated | Not stated |
| NCT01020305 | Temsirolimus to Reverse Androgen Insensitivity for Castration-resistant Prostate Cancer | Phase 1 / Phase 2 | terminated | Nov 25, 2009 | Sandy Srinivas | Decision by funding sponsor due to poor accrual | Enrollment / accrual |
| NCT01149434 | Study of JI-101 in Patients With Advanced Low Grade Endocrine Tumors, Ovarian Cancers or… | Phase 1 / Phase 2 | terminated | Jun 23, 2010 | University of Utah | Lack of drug efficacy | Efficacy / futility |
| NCT01095367 | Seprafilm™ for the Prevention of Intraperitoneal Adhesions and Improved Delivery of… | N/A | terminated | Mar 30, 2010 | University of British Columbia | due to company changes and lack of funding-unlikely to have sufficient numbers to analyze… | Funding |
| NCT01704027 | Safety Study of Pelvic and Prostatic SIB-IMRT With Long-term Androgen Deprivation for… | Phase 2 | terminated | Oct 11, 2012 | Centre Georges Francois Leclerc | termination of the trial after interim analysis. the main criterion could not be reached | Efficacy / futility |
| NCT02017678 | Phase 2 Study of JX-594 in Patients With Peritoneal Carcinomatosis of Ovarian Cancer… | Phase 2 | withdrawn | Dec 23, 2013 | Andrea McCart | not stated | Not stated |
| NCT01943058 | Megestrol Acetate or Levonorgestrel-Releasing Intrauterine System in Treating Patients… | Phase 2 | withdrawn | Sep 16, 2013 | University of Southern California | Lack of funding | Funding |
| NCT01786226 | Mifepristone to Treat Uterine Fibroids | Phase 2 / Phase 3 | terminated | Feb 7, 2013 | Mediterranea Medica S. L. | not stated | Not stated |
| NCT00958893 | An Extension Study Evaluating Safety and Efficacy of Proellex® In Women Who Have… | Phase 2 | terminated | Aug 13, 2009 | Repros Therapeutics Inc. | Repros stopped the study for safety and FDA put the study on hold for safety. | Safety / toxicity |
| NCT00470067 | Doxorubicin Hydrochloride Liposome and Carboplatin in Treating Patients With Recurrent,… | Phase 2 | terminated | May 7, 2007 | Roswell Park Cancer Institute | Due to low accrual | Enrollment / accrual |
| NCT00536523 | Effect of Serotonin Level on Constipation Caused by Chemotherapy in Patients With… | — | terminated | Sep 28, 2007 | University of Minnesota | Funding unavailable | Funding |
| NCT01284075 | The Effect of Guided Imagery and Music Therapy on Post-Operative Recovery After… | N/A | terminated | Jan 26, 2011 | University of Minnesota | Low accrual | Enrollment / accrual |
| NCT00683917 | Pharmacokinetics, Safety and Efficacy Study of Proellex in Pre-menopausal Women With… | Phase 2 | terminated | May 26, 2008 | Repros Therapeutics Inc. | Repros stopped the study for safety and FDA put the study on hold for safety. | Safety / toxicity |
| NCT00702702 | Safety and Efficacy of Proellex in Pre-menopausal Anemic Women With Symptomatic Uterine… | Phase 3 | terminated | Jun 20, 2008 | Repros Therapeutics Inc. | Repros stopped study for safety and FDA put study on hold because of safety. | Safety / toxicity |
| NCT00735553 | Evaluating the Safety and Efficacy of Proellex® (CDB-4124) in Premenopausal Women With… | Phase 3 | terminated | Aug 15, 2008 | Repros Therapeutics Inc. | Repros stopped the study for safety and FDA put the study on hold for safety. | Safety / toxicity |
| NCT00737282 | Multicenter Study Evaluating the Safety of Proellex® in Premenopausal Women With Uterine… | Phase 3 | terminated | Aug 18, 2008 | Repros Therapeutics Inc. | Repros stopped study for safety and FDA put study on hold. | Safety / toxicity |
| NCT00785356 | Safety and Efficacy of Proellex in Pre-Menopausal Anemic Women With Symptomatic Uterine… | Phase 3 | terminated | Nov 5, 2008 | Repros Therapeutics Inc. | Repros stopped the study for safety and FDA put the study on hold for safety. | Safety / toxicity |
| NCT00853567 | Evaluating the Safety and Efficacy of Proellex® in Premenopausal Women With Symptomatic… | Phase 3 | terminated | Mar 2, 2009 | Repros Therapeutics Inc. | Repros stopped the study for safety and FDA put the study on hold for safety. | Safety / toxicity |
| NCT01069120 | Safety of 25 and 50 mg Proellex® in the Treatment of Women With Symptomatic Uterine… | Phase 3 | terminated | Feb 17, 2010 | Repros Therapeutics Inc. | Repros stopped study due to safety and FDA placed study on hold | Safety / toxicity |
| NCT00385827 | A Safety and Efficacy Study of Siltuximab (CNTO 328) in Male Subjects With Metastatic… | Phase 2 | terminated | Oct 11, 2006 | Centocor, Inc. | Prematurely stopped after Independent Data Monitoring Committee (IDMC) evaluation for lack of… | Efficacy / futility |
| NCT01606358 | Influence of Chemotherapy on Gamma-delta T Cells in Patients With Epithelial Ovarian…(IClyCO) | — | withdrawn | May 25, 2012 | Rennes University Hospital | not stated | Not stated |
| NCT00004050 | Leuvectin Followed By Surgery in Treating Patients With Stage II or Stage III Prostate… | Phase 2 | terminated | Oct 29, 2003 | Vical | Development in prostate cancer indication halted | Other (stated, no rule matched) |
| NCT00005072 | Leuvectin in Treating Patients With Locally Recurrent Prostate Cancer | Phase 1 / Phase 2 | terminated | Nov 4, 2003 | Vical | Development in prostate cancer indication halted | Other (stated, no rule matched) |
| NCT01550380 | BKM120 in Advanced, Metastatic, or Recurrent Endometrial Cancers(BKM120) | Phase 2 | withdrawn | Mar 12, 2012 | University of Utah | not stated | Not stated |
| NCT01688414 | Imaging During Surgery in Diagnosing Patients With Prostate, Bladder, or Kidney Cancer | N/A | withdrawn | Sep 19, 2012 | Stanford University | PI left Stanford | Investigator |
| NCT02054793 | Phase Ib/II Study Evaluating Orteronel (Without Prednisone) Combined With Itraconazole In… | Phase 1 / Phase 2 | withdrawn | Feb 4, 2014 | Emmanuel Antonarakis, MD | This study was never able to open due to lack of funding from the pharmaceutical company. | Funding |
| NCT00610662 | Digital Colposcopy in Finding Cervical Intraepithelial Neoplasia in Patients With An… | — | withdrawn | Feb 8, 2008 | British Columbia Cancer Agency | Study modified and has been running as CDR0000581286 instead. | Other (stated, no rule matched) |
| NCT00626561 | Bevacizumab and Paclitaxel for Neuroendocrine Tumors of the Cervix | Phase 2 | terminated | Feb 29, 2008 | M.D. Anderson Cancer Center | Due to slow accrual. | Enrollment / accrual |
| NCT00949962 | Post-operative or Early Salvage XRT and ADT for High Risk PCa | Phase 3 | terminated | Jul 31, 2009 | European Organisation for Research and Treatment of Cancer - EORTC | Poorly recruiting | Enrollment / accrual |
| NCT00874302 | Safety and Efficacy of 25 and 50 mg Doses of Proellex® in Treating the Recurrence of… | Phase 3 | withdrawn | Apr 2, 2009 | Repros Therapeutics Inc. | Study terminated for safety and the FDA put the study on hold for safety. | Safety / toxicity |
| NCT00418093 | Oxaliplatin, Gemcitabine and Bevacizumab in Women With Recurrent Mullerian Carcinoma | Phase 2 | terminated | Jan 4, 2007 | Dana-Farber Cancer Institute | THe study was terminated early due to a lack of accural | Other (stated, no rule matched) |
| NCT00515112 | Testosterone Replacement in Men With Non-Metastatic Castrate Resistant Prostate Cancer | Phase 2 | terminated | Aug 13, 2007 | University of Chicago | This study has been terminated due to poor accrual | Enrollment / accrual |
| NCT00089076 | MDX-010 in Treating Patients With Recurrent or Refractory Lymphoma | Phase 1 / Phase 2 | terminated | Aug 5, 2004 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00835679 | Cetuximab and/or Dasatinib in Patients With Colorectal Cancer and Liver Metastases That… | Early Phase 1 | terminated | Feb 4, 2009 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00003094 | Carotenoid Rich Diet in Treating Cervical Dysplasia | Phase 2 | withdrawn | Apr 27, 2004 | University of California, San Diego | Study was halted prematurely, prior to enrollment of first participant | Enrollment / accrual |
| NCT01483586 | Safety and Efficacy of Kanglaite Gelcaps in Prostate Cancer | Phase 2 | terminated | Dec 1, 2011 | KangLaiTe USA | Sponsor decision | Sponsor / business decision |
| NCT00678015 | Pharmacokinetic and Efficacy Study of Nordihydroguaiaretic Acid (NDGA) in Non Metastatic… | Phase 2 | terminated | May 15, 2008 | University of California, San Francisco | Per protocol - interim analysis showed no significant PSA declines among the first 12 patients… | Efficacy / futility |
| NCT01233505 | Veliparib, Oxaliplatin, and Capecitabine in Treating Patients With Advanced Solid Tumors | Phase 1 | terminated | Nov 3, 2010 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT01602783 | 11C Acetate Imaging Post Prostatectomy | N/A | terminated | May 21, 2012 | Massachusetts General Hospital | Slow accrual; no further funding | Enrollment / accrual |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Jan 5, 2015source: clinicaltrials