Terminated, withdrawn and suspended trials

clinicaltrialsObservedShowing 51–100 of 171 studies, most recently updated first

NCT	Title	Phase	Status	First posted	Lead sponsor	Why stopped (as posted)	Category
NCT01347645	Irinotecan Plus E7820 Versus FOLFIRI in Second-Line Therapy in Patients With Locally…	Phase 1 / Phase 2	terminated	May 4, 2011	Eisai Inc.	The study was terminated by the Sponsor due to E7820 plus irinotecan being potentially inferior to…	Other (stated, no rule matched)
NCT02682485	Serial Endoscopic Surveillance & Direct Topical Antibiotics to Define the Role of…(SES-DTA)	Phase 2	withdrawn	Feb 15, 2016	University of Chicago	Lack of funding	Funding
NCT01160926	Dual REctcal Angiogenesis or MEK Inhibition radioTHERAPY Trial(DREAMtherapy)	Phase 1	terminated	Jul 13, 2010	The Christie NHS Foundation Trust	2 DLTs had been reported from first 4 patients on lowest possible dose cohort.	Other (stated, no rule matched)
NCT04177602	Evaluating Trifluridine/Tipiracil Based Chemoradiation in Locally Advanced Rectal Cancer…	Phase 1 / Phase 2	terminated	Nov 26, 2019	Universitätsklinikum Hamburg-Eppendorf	Due to the amended therapy strategies for rectal cancer recently, it was decided not to transfer…	Sponsor / business decision
NCT04150705	PET/MR for Rectal Cancer Treatment Monitoring and Surveillance	N/A	terminated	Nov 5, 2019	Washington University School of Medicine	It was determined that the trial could stop early due to surpassing the feasibility rate.	Other (stated, no rule matched)
NCT02910843	Neoadjuvant Treatment With Regorafenib and Capecitabine Combined With Radiotherapy in…(RECAP)	Phase 1	terminated	Sep 22, 2016	Swiss Cancer Institute	due to structural financial deficit of SAKK	Funding
NCT04044430	Encorafenib, Binimetinib, and Nivolumab in Treating Microsatellite Stable BRAF V600E…	Phase 1	terminated	Aug 5, 2019	University of California, San Francisco	Sponsor funding	Funding
NCT03693846	Nivolumab and Ipilimumab in Mucinous Colorectal and Appendiceal Tumors	Phase 2	terminated	Oct 3, 2018	Abramson Cancer Center at Penn Medicine	Terminated due to slow enrollment and lack of efficacy	Efficacy / futility
NCT03781778	Pilot Trial of Resistant Starch in Stage I-III Colorectal Cancer Survivors	Phase 2	terminated	Dec 20, 2018	Fred Hutchinson Cancer Center	Terminated due to expiration of funding	Funding
NCT04372992	The Stoma Closure Before or After Adjuvant Therapy Trial(STOMAD)	N/A	terminated	May 4, 2020	Ospedale Umberto I di Torino	Low accrual - no restart after pandemic suspension	COVID-19 / pandemic
NCT05018325	Assessing Effect of Withdrawal Time on Adenoma Detection Rate for Screening Colonoscopy	N/A	terminated	Aug 24, 2021	Washington University School of Medicine	Futility	Efficacy / futility
NCT04670588	Response Assessment by Circulating Tumor DNA in Patients With Locally Advanced Rectal…	—	withdrawn	Dec 17, 2020	Medical College of Wisconsin	No accrual.	Enrollment / accrual
NCT02445456	Feasibility of Sentinel Lymph Node Biopsy in Rectal Cancer(SentiRect)	N/A	terminated	May 15, 2015	Oxford University Hospitals NHS Trust	Logistical difficulties in recruiting patients led to slower than expected recruitment. Recruitment…	COVID-19 / pandemic
NCT02933944	Exploratory Study of TG02-treatment as Monotherapy or in Combination With Pembrolizumab…	Phase 1	terminated	Oct 14, 2016	Targovax ASA	Changing priorities	Other (stated, no rule matched)
NCT02465593	A Study of PEP503(Radio-enhancer) With Radiotherapy and Chemotherapy for Patients With…	Phase 1 / Phase 2	terminated	Jun 8, 2015	PharmaEngine	not stated	Not stated
NCT01285102	Chemoembolization Using Irinotecan in Treating Patients With Liver Metastases From…	Phase 1	terminated	Jan 27, 2011	Fox Chase Cancer Center	This study was closed early by the DSMB due to increased toxicity.	Safety / toxicity
NCT01995396	Hartmanns Procedure or Abdominoperineal Excision With Intersphincteric Dissection in…(HAPIrect)	N/A	terminated	Nov 26, 2013	Region Västmanland	Decision after interims analysis	Other (stated, no rule matched)
NCT04418895	Neoadjuvant Therapy for Localized Rectal Adenocarcinoma	Phase 2	withdrawn	Jun 5, 2020	UNC Lineberger Comprehensive Cancer Center	lack of resources	Other (stated, no rule matched)
NCT02319304	Pelvic Radiotherapy With Concurrent Neoadjuvant FOLFOX for Patients With Newly Diagnosed…(GCC 1314)	Phase 2	terminated	Dec 18, 2014	University of Maryland, Baltimore	Slow accrual, PI left instituion	Investigator
NCT03699410	Observational Study on Rectal Cancer to Verify if Response After Chemo-radiotherapy Can…(LiBReCa)	—	terminated	Oct 9, 2018	Dimitri Christoforidis	failure to identify complete responders since ctDNA disappears after radiotherapy in most patients.	Other (stated, no rule matched)
NCT02163785	Abdominoperineal Extra-Elevators Rectal Resection for Cancer: Prone Position vs. Supine…(APPRO)	N/A	terminated	Jun 16, 2014	Hospital Universitario La Fe	insufficient recruitment rate	Enrollment / accrual
NCT04620473	Anlotinib Hydrochloride Combined With Capeox in the Neoadjuvant Treatment of Locally…	Phase 2	withdrawn	Nov 9, 2020	Shanghai Minimally Invasive Surgery Center	No approval from ethical committee	Other (stated, no rule matched)
NCT03280277	Ferumoxytol-Enhanced MRI in Imaging Lymph Nodes in Patients With Locally Advanced Rectal…	Early Phase 1	terminated	Sep 12, 2017	OHSU Knight Cancer Institute	low accrual	Enrollment / accrual
NCT03633539	Single-incision Versus Conventional Laparoscopic Surgery for Colorectal Cancer(mSILSC)	N/A	withdrawn	Aug 16, 2018	Ruijin Hospital	No research funds were raised	Funding
NCT02550743	BrUOG 302:BYL719, Capecitabine and Radiation for Rectal Cancer: A Brown University…	Phase 1	terminated	Sep 15, 2015	howard safran	lack of accural	Other (stated, no rule matched)
NCT02614157	Lateral Lymph Node Dissection After Neoadjuvant Chemo-radiation in Advanced Low Rectal…	N/A	terminated	Nov 25, 2015	West China Hospital	The enrollment was too low	Enrollment / accrual
NCT03170115	Induction Chemotherapy Plus Chemoradiotherapy With or Without Aspirin in High Risk Rectal…(ICAR)	Phase 2	terminated	May 30, 2017	Instituto Nacional de Cancer, Brazil	Aspirin added to chemoradiotherapy was safe but did not improve response to total neoadjuvant…	Other (stated, no rule matched)
NCT03257332	Determining Early Development of Faecal Incontinence and Anorectal Muscle Function After…(EDFI-Cohort)	—	withdrawn	Aug 22, 2017	Slagelse Hospital	Not possible to include participants	Other (stated, no rule matched)
NCT01097239	Examining the Role of Transrectal High Intensity Focused Ultrasound (HIFU) in Rectal…	Phase 1 / Phase 2	withdrawn	Apr 1, 2010	Imperial College London	Failure to recruit.	Enrollment / accrual
NCT02010567	Neoadjuvant Chemoradiotherapy With CRLX-101 and Capecitabine for Rectal Cancer	Phase 1 / Phase 2	terminated	Dec 12, 2013	UNC Lineberger Comprehensive Cancer Center	The study was halted prematurely at the funding partner's request.	Funding
NCT00671645	Preoperative Combined RadioChemo-Molecular Target Therapy With Capecitabine, Bevacizumab,…	Phase 2	terminated	May 5, 2008	Austrian Breast & Colorectal Cancer Study Group	reaching of step 1 (recruitment of 8 patients) per protocol -\> risk assessment -\> termination…	Safety / toxicity
NCT01302613	Altered Chemotherapy Sequencing During Neoadjuvant Therapy for Patients With Stage II or…	Phase 1 / Phase 2	withdrawn	Feb 24, 2011	University of Texas Southwestern Medical Center	Drug shortage	Other (stated, no rule matched)
NCT02205307	A Study Assessing Perfusion Outcomes With PINPOINT® Near Infrared Fluorescence Imaging in…(PILLAR III)	N/A	terminated	Jul 31, 2014	Novadaq Technologies ULC, now a part of Stryker	Slow recruitment	Enrollment / accrual
NCT03258541	Organ-sparing With TraceIT® for Rectal Cancer Radiotherapy	N/A	terminated	Aug 23, 2017	Thomas Zilli	Surgical access not facilitated- residues of hydrogel.	Other (stated, no rule matched)
NCT02052921	Observation Versus Surgical Resection in Patients With Rectal Cancer Who Achieved…	N/A	terminated	Feb 3, 2014	Instituto do Cancer do Estado de São Paulo	During the execution time foreseen in the project, the expected number of patients was not reached.	Other (stated, no rule matched)
NCT03487484	Quality of Life in Patients With Rectal Cancer Receiving Total Mesorectal Excision With…	—	terminated	Apr 4, 2018	University Hospital, Basel, Switzerland	insufficient recruitment	Enrollment / accrual
NCT00353457	Capecitabine,Oxaliplatin & Erbitux Given Throughout Multi-Modal Therapy for Locally…	Phase 2	terminated	Jul 18, 2006	Abramson Cancer Center at Penn Medicine	new studies were finding that Erbitux was not beneficial	Other (stated, no rule matched)
NCT00207831	Trial Testing Ftorafur (UFT) Associated With Neoadjuvant Radiotherapy Versus Radiotherapy…(UFT RT Phase 3)	Phase 3	terminated	Sep 21, 2005	Institut Cancerologie de l'Ouest	Terminated after interim analysis	Efficacy / futility
NCT02797405	Tumour and HEalthy Tissues DOse-response and Radiosensitivity Assay(THEODORA)	N/A	terminated	Jun 13, 2016	Centre Leon Berard	Withdrawal of analysis study Partner.	Other (stated, no rule matched)
NCT03049124	Exercise for Adults Diagnosed With Rectal Cancer	N/A	withdrawn	Feb 9, 2017	University of Ottawa	We were unable to enroll participants into the study.	Enrollment / accrual
NCT03413930	Transanal Versus Laparoscopic Total Mesorectal Excision for Rectal Cancer	N/A	withdrawn	Jan 29, 2018	Ruijin Hospital	No funding was raised	Funding
NCT02425683	Study of Colorectal Cancer Patients (Stage IIIC) With Either Regorafenib or Standard of…	Phase 2	terminated	Apr 24, 2015	US Oncology Research	insufficient accrual	Enrollment / accrual
NCT00580073	Phase II Trial of Neoadjuvant FOLFOX4 and Cetuximab for Localized Adenocarcinoma of Rectum	Phase 2	terminated	Dec 24, 2007	University of Wisconsin, Madison	Loss of funding	Funding
NCT02290574	Efficacy of NeoThermo-Radio-chemotherapy for LA Rectal Cancer Before Laparoscopic TME:…(NEOTREAT)	N/A	terminated	Nov 14, 2014	Samsung Medical Center	slow accrual	Enrollment / accrual
NCT00397878	AZD0530 (NSC 735464) in Treating Patients With Previously Treated Metastatic Colon Cancer…	Phase 2	terminated	Nov 10, 2006	National Cancer Institute (NCI)	The study was terminated after all enrolled participants progressed.	Enrollment / accrual
NCT02233595	Evaluation of Rectal Cancer Treatment Response Using PET/MRI(Rectal PET/MRI)	—	terminated	Sep 8, 2014	University of California, San Francisco	Low Accrual	Enrollment / accrual
NCT03204201	Validation of ICG to Identify the Urethra During Rectal Surgery	Phase 1 / Phase 2	terminated	Jun 29, 2017	Oxford University Hospitals NHS Trust	Technique failed	Other (stated, no rule matched)
NCT03204994	Fluorescence Targeted Pelvic Lymph Node Mapping	Phase 1 / Phase 2	terminated	Jul 2, 2017	Oxford University Hospitals NHS Trust	Not able to recruit	Enrollment / accrual
NCT03161574	FOLFOXIRI Chemotherapy Alone as Neoadjuvant Treatment for Circumferential Radial Margin…	Phase 2	withdrawn	May 22, 2017	Guangxi Medical University	No participants were recruited	Enrollment / accrual
NCT02585271	Transanal Decompression Tube Versus Stent for Acute Malignant Left-sided Colonic and…	N/A	terminated	Oct 23, 2015	Xuzhou Central Hospital	We can not get enough sample size.	Other (stated, no rule matched)

Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.

Data updated 22 days agoSource updated Jun 22, 2023source: clinicaltrials

Terminated, withdrawn and suspended studies

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