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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
840 stopped studies mapped to Malignant Prostate Neoplasm and descendants · 92% state a reason
Over the 840 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT03619655 | Assessment of Multi-Modality Quantitative Imaging for Evaluation of Response of… | Phase 1 | terminated | Aug 8, 2018 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | Due to changing prostate cancer standard of care, the research question became obsolete as the… | Other (stated, no rule matched) |
| NCT03649841 | Antiandrogen Therapy, Abiraterone Acetate, and Prednisone With or Without Neutron… | Phase 2 | terminated | Aug 28, 2018 | University of Washington | Terminated due to low accrual. | Enrollment / accrual |
| NCT03824808 | Effect of Perioperative Intravenous Lidocaine Infusion in Robotic-Assisted Urologic… | Phase 4 | terminated | Jan 31, 2019 | University of Missouri-Columbia | Challenges with recruitment of surgical research subjects in the target population. | Enrollment / accrual |
| NCT02626377 | Multicenter Prospective Cohort of Informal Caregivers in Burgundy and Franche-Comté(ICE) | N/A | terminated | Dec 10, 2015 | Centre Hospitalier Universitaire de Besancon | inclusions problems | Other (stated, no rule matched) |
| NCT03180398 | Multi-parametric Magnetic Resonance Imaging for Prostate Cancer Patients | N/A | terminated | Jun 8, 2017 | Henry Ford Health System | PI left institution | Investigator |
| NCT01420861 | GTx-758 on Serum Prostate-specific Antigen (PSA) in Men With Castrate Resistant Prostate… | Phase 2 | terminated | Aug 22, 2011 | GTx | FDA Clinical Hold | Other (stated, no rule matched) |
| NCT00769652 | Medical Nutrition Therapy or Standard Care in Treating Patients With Lung Cancer,… | N/A | terminated | Oct 9, 2008 | Rutgers, The State University of New Jersey | slow accrual | Enrollment / accrual |
| NCT01377389 | Ipilimumab + Androgen Depravation Therapy in Prostate Cancer | Phase 2 | terminated | Jun 21, 2011 | M.D. Anderson Cancer Center | Due to adverse events | Safety / toxicity |
| NCT03999515 | Erdafitinib and Abiraterone Acetate or Enzalutamide in Treating Patients With Double… | Phase 2 | terminated | Jun 26, 2019 | University of Washington | Terminated due to slow accrual | Enrollment / accrual |
| NCT03752099 | To Evaluate Safety and Tolerability of VERU-111 in Men With Advanced Metastatic… | Phase 1 / Phase 2 | terminated | Nov 23, 2018 | Veru Inc. | Administrative decision | Other (stated, no rule matched) |
| NCT05301062 | A Research Called CREDIT Studies How Safe the Study Treatment Radium-223 is and How Well…(CREDIT) | — | terminated | Mar 29, 2022 | Bayer | Due to the changes of standard of care, the slow recruitment of participants, and the similar… | Safety / toxicity |
| NCT05567679 | A Study of Tazemetostat (Tazverik) Before Prostatectomy in Men With Prostate Cancer | Early Phase 1 | withdrawn | Oct 5, 2022 | Edwin Posadas, MD | PI voluntarily closed the study. | Other (stated, no rule matched) |
| NCT05771896 | Darolutamide With Radium-223 or Placebo and the Effect on Radiological Progression-Free…(CARE) | Phase 3 | withdrawn | Mar 16, 2023 | GenesisCare USA | Bayer withdrew their support. | Other (stated, no rule matched) |
| NCT00176644 | Phase II Trial of Transdermal Estradiol for Hormone Refractory Prostate Cancer | Phase 2 | terminated | Sep 15, 2005 | University of Medicine and Dentistry of New Jersey | Treatment ineffective | Other (stated, no rule matched) |
| NCT00483561 | Gefitinib and Etoposide in Treating Patients With Advanced Prostate Cancer That Did Not… | Phase 2 | terminated | Jun 7, 2007 | University of Nebraska | PI left UNMC | Investigator |
| NCT01093183 | Lenalidomide and Cyclophosphamide in Treating Patients With Previously Treated… | Phase 1 / Phase 2 | terminated | Mar 25, 2010 | University of Nebraska | study sponsors withdrew support for the study drug. | Other (stated, no rule matched) |
| NCT05437679 | Characterization of Circulating Tumor Cells (CTCs) in High Risk and Early Metastatic…(CHARTER) | — | terminated | Jun 29, 2022 | Angle plc | Futility (slow enrollment) | Efficacy / futility |
| NCT00499174 | Observation or Radical Treatment in Patients With Prostate Cancer | N/A | terminated | Jul 11, 2007 | NCIC Clinical Trials Group | Not meeting accrual target. | Enrollment / accrual |
| NCT04227275 | A Study of CART-PSMA-TGFβRDN in Patients With Metastatic Castration Resistant Prostate… | Phase 1 | terminated | Jan 13, 2020 | Tceleron Therapeutics, Inc. | Based on the safety events and evidence of biologic activity without sustained clinical responses… | Safety / toxicity |
| NCT05489991 | A Study of TmPSMA-02 Chimeric Antigen Receptor (CAR) T-cells in Patients With Metastatic… | Phase 1 / Phase 2 | terminated | Aug 5, 2022 | Tceleron Therapeutics, Inc. | Study was stopped Sponsor discretion. No patients were dosed. | Other (stated, no rule matched) |
| NCT05098327 | Pioglitazone and Insulin Resistance in ADT | Phase 3 | withdrawn | Oct 28, 2021 | State University of New York at Buffalo | no participant enrolled due to lack of interest. | Enrollment / accrual |
| NCT00786682 | Docetaxel and Hydroxychloroquine in Treating Patients With Metastatic Prostate Cancer | Phase 2 | terminated | Nov 6, 2008 | University of Medicine and Dentistry of New Jersey | Lack of improved efficacy compared to historical controls, competing studies | Efficacy / futility |
| NCT01555632 | Atorvastatin Calcium in Preventing Metabolic Syndrome in Prostate Cancer Patients… | N/A | withdrawn | Mar 15, 2012 | University of Nebraska | Other more favorable treatments are now available. | Other (stated, no rule matched) |
| NCT04066894 | Sacral Nerve Stimulation in Treating Low Anterior Resection Syndrome or Fecal… | Phase 2 | terminated | Aug 26, 2019 | M.D. Anderson Cancer Center | Due to Issues Enrolling Patients | Enrollment / accrual |
| NCT04575766 | A Study of FT-7051 in Men With MCRPC | Phase 1 | terminated | Oct 5, 2020 | Novo Nordisk A/S | Sponsor Decision | Sponsor / business decision |
| NCT00651326 | Androgen Suppression and Radiation With/Out Docetaxel in High-Risk Localized Prostate…(DART) | Phase 3 | terminated | Apr 2, 2008 | NCIC Clinical Trials Group | Poor accrual | Enrollment / accrual |
| NCT05010759 | Study of Focal Ablation of the Prostate With NanoTherm® Therapy System for… | N/A | terminated | Aug 18, 2021 | MagForce USA | Inadequate enrollment and company changing direction | Enrollment / accrual |
| NCT04424641 | A Study on the Safety of GEN1044 (DuoBody®-CD3x5T4) in Patients With Malignant Solid… | Phase 1 / Phase 2 | terminated | Jun 11, 2020 | Genmab | Study was terminated due to MTD was reached | Other (stated, no rule matched) |
| NCT04541225 | Study of NUV-422 in Adults With Recurrent or Refractory High-grade Gliomas and Solid… | Phase 1 | terminated | Sep 9, 2020 | Nuvation Bio Inc. | Sponsor decision | Sponsor / business decision |
| NCT04781374 | Neratinib in Patients With Metastatic Castration-Resistant Prostate Cancer | Phase 2 | withdrawn | Mar 4, 2021 | Beth Israel Deaconess Medical Center | Withdrawal of funding | Funding |
| NCT03927573 | Study With Bispecific Antibody Engaging T-cells, in Patients With Progressive Cancer… | Phase 1 | terminated | Apr 25, 2019 | AvenCell Europe GmbH | business decision by sponsor | Sponsor / business decision |
| NCT05363644 | BioDFence® G3 For Full Nerve-Sparing Robotic-Assisted Radical Prostatectomy | Phase 3 | withdrawn | May 6, 2022 | AdventHealth | Study was withdrawn due to lack of funding | Funding |
| NCT02640534 | Investigation of Metformin in Patients With Castration Resistant Prostate Cancer in… | Phase 2 | terminated | Dec 29, 2015 | Swiss Cancer Institute | The decision is based on the fact that with the current follow up of around 10 years, the relevant… | Other (stated, no rule matched) |
| NCT04995978 | Insulin Resistance and Androgen Deprivation Therapy | Phase 2 | withdrawn | Aug 9, 2021 | St. Louis University | No participants were recruited and the study was deemed not feasible | Enrollment / accrual |
| NCT00002668 | Pain Control in Patients With Recurrent or Metastatic Breast or Prostate Cancer | N/A | terminated | Jan 27, 2003 | Eastern Cooperative Oncology Group | Slow accrual | Enrollment / accrual |
| NCT01326312 | Effect of GTx-758 on Total and Free Testosterone Levels in Men With Prostate Cancer(GTx758) | Phase 2 | terminated | Mar 30, 2011 | GTx | FDA Clinical Hold | Other (stated, no rule matched) |
| NCT02516670 | Docetaxel With or Without Ascorbic Acid in Treating Patients With Metastatic Prostate… | Phase 2 | terminated | Aug 6, 2015 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | insufficient clinical response per DSMB | Other (stated, no rule matched) |
| NCT05742334 | Evaluating Return to Continence and Potency Following Radical Prostatectomy | N/A | withdrawn | Feb 24, 2023 | Wake Forest University Health Sciences | The sponsor decided to not move forward with this study | Sponsor / business decision |
| NCT03553212 | Twice High Dose External Beam Radiotherapy by Image-guided Tomotherapy for Organ-confined…(THRIP) | N/A | terminated | Jun 12, 2018 | Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l. IRCCS | outdated, progress in clinical practice. | Other (stated, no rule matched) |
| NCT00771017 | Androgen Ablation Therapy With or Without Vaccine Therapy in Treating Patients With… | Phase 2 | withdrawn | Oct 10, 2008 | Eastern Cooperative Oncology Group | not stated | Not stated |
| NCT03535675 | Muscadine Plus (MPX) In Men With Prostate Cancer | Phase 3 | terminated | May 24, 2018 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | The study was terminated by DSMB due to futility. | Efficacy / futility |
| NCT04483414 | 68Ga PSMA-11 PET/CT in Recurrent Prostate Cancer | Phase 2 | withdrawn | Jul 23, 2020 | Dana Mathews | Study was closed since no participants were enrolled. | Enrollment / accrual |
| NCT04843319 | To Determine an Effective Dose of VERU-100 for the Treatment of Advanced Prostate Cancer(VERU-100) | Phase 1 / Phase 2 | terminated | Apr 13, 2021 | Veru Inc. | Study terminated as end points were not achieved at current dose level. | Other (stated, no rule matched) |
| NCT04658849 | Insulin Resistance Following ADT for Prostate CA | Early Phase 1 | withdrawn | Dec 9, 2020 | St. Louis University | End of grant funding | Funding |
| NCT04077021 | First-in-human Study of CCW702 in Patients With Metastatic Castration Resistant Prostate… | Phase 1 | terminated | Sep 4, 2019 | Calibr, a division of Scripps Research | Business decision | Sponsor / business decision |
| NCT02968784 | Focal ExAblate MR-Guided Focused Ultrasound Treatment for Management of Organ-Confined… | N/A | terminated | Nov 21, 2016 | InSightec | Sponsor Decision | Sponsor / business decision |
| NCT04879589 | Phase 1 Study of ATRS-2002 in Healthy Male Adults | Phase 1 | withdrawn | May 10, 2021 | Syneos Health | Study abandoned, no participants enrolled | Enrollment / accrual |
| NCT03574194 | Methionine-Restricted Diet to Potentiate The Effects of Radiation Therapy | N/A | terminated | Jun 29, 2018 | West Virginia University | Suspended due to COVID-19 pandemic | COVID-19 / pandemic |
| NCT03919214 | Hypertension Management in Cancer Patients | N/A | terminated | Apr 18, 2019 | Duke University | Initially suspended due to Covid-19. After much consideration, it was determined that we do not… | COVID-19 / pandemic |
| NCT04085991 | Two TraCer PositROn EmiSSion Tomography ComBination for Efficacy EstimatiOn of Prostate…(CROSSBOW) | Phase 2 | terminated | Sep 11, 2019 | Sir Mortimer B. Davis - Jewish General Hospital | Drug no longer available | Other (stated, no rule matched) |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Oct 31, 2023source: clinicaltrials