Clinical trial · Interventional
Effect of Perioperative Intravenous Lidocaine Infusion in Robotic-Assisted Urologic Surgery
A Prospective, Randomized, Double-Blinded, Placebo-Controlled Clinical Trial Evaluating the Use of Perioperative Intravenous Lidocaine Infusion to Decrease Pain Scores and Opioid Consumption After Robotic-Assisted Prostatectomy and Robotic-Assisted Partial Nephrectomy
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): Challenges with recruitment of surgical research subjects in the target population.
Summary
Brief summary (as posted)
Controlling pain is fundamental during and after surgical procedures. This study examines pain associated with robotic assisted surgery on prostate cancer or a kidney mass. In recent years, the risk of opioids in the postoperative period has gained interest due to the growing epidemic of addiction, dependence, and overdose. In this study, the investigators expect a continuous infusion of intravenous lidocaine during the perioperative period to result in less pain and less opioid use.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Kidney Cancer | Malignant Kidney Neoplasm | CURATED_EXACT | 0.92 |
| Prostate Cancer | Malignant Prostate Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| 0.9% Sodium Chloride Injection | Drug | — | UNRESOLVED |
| Lidocaine Hydrochloride 0.8% in Dextrose 5% Solution | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Treatment group
- description
- Lidocaine Hydrochloride 0.8% in Dextrose 5% Solution
- interventionNames
- Drug: Lidocaine Hydrochloride 0.8% in Dextrose 5% Solution
- type
- PLACEBO_COMPARATOR
- label
- Control group
- description
- 0.9% Sodium Chloride Injection
- interventionNames
- Drug: 0.9% Sodium Chloride Injection
Primary outcomes (1)
- measure
- Difference in Post-operative Pain Scores Measured by Visual Analog Scale
- timeFrame
- Through study completion, assessed at 1h, 2h, 4h, 6h, 12h and 24h post operatively, then every 24 hours until discharge, and at the post operative visit which occurred within 21-days post-operatively.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Undergoing robotic assisted prostatectomy or robotic assisted partial nephrectomy at University of Missouri Hospital for prostate cancer or kidney mass * Age ≥ 18 years * ASA I-III Exclusion Criteria: * Inability to obtain written informed consent * Allergy to lidocaine or other amide local anesthetics * Atrioventricular conduction blocks * CV instability and concomitant use of alpha agonists or beta blockers * Recent myocardial infarction (≤ 6 months ago) * Cardiac arrhythmia disorders * Stokes-Adams syndrome * Wolff-Parkinson-White syndrome * Seizure disorders * Liver failure or hepatic dysfunction * Significant renal disease with a serum creatinine ≥ 2 mg/dl * A family history of malignant hyperthermia * Current use of opioids or documented history of opioid abuse * Typically, have less than 3 bowel movement per week * Combined surgical cases that include robotic prostatectomy or robotic partial nephrectomy
References
Publications (16)
- BACKGROUNDBates C, Laciak R, Southwick A, Bishoff J. Overprescription of postoperative narcotics: a look at postoperative pain medication delivery, consumption and disposal in urological practice. J Urol. 2011 Feb;185(2):551-5. doi: 10.1016/j.juro.2010.09.088. Epub 2010 Dec 18. PMID 21168869
- BACKGROUNDHedegaard H, Warner M, Minino AM. Drug Overdose Deaths in the United States, 1999-2016. NCHS Data Brief. 2017 Dec;(294):1-8. PMID 29319475
- BACKGROUNDCenters for Disease Control and Prevention (CDC). Vital signs: overdoses of prescription opioid pain relievers---United States, 1999--2008. MMWR Morb Mortal Wkly Rep. 2011 Nov 4;60(43):1487-92. PMID 22048730
- BACKGROUNDDunn LK, Durieux ME. Perioperative Use of Intravenous Lidocaine. Anesthesiology. 2017 Apr;126(4):729-737. doi: 10.1097/ALN.0000000000001527. No abstract available. PMID 28114177
- BACKGROUNDDe Oliveira GS Jr, Fitzgerald P, Streicher LF, Marcus RJ, McCarthy RJ. Systemic lidocaine to improve postoperative quality of recovery after ambulatory laparoscopic surgery. Anesth Analg. 2012 Aug;115(2):262-7. doi: 10.1213/ANE.0b013e318257a380. Epub 2012 May 14. PMID 22584558
- BACKGROUNDJoshi GP, Jaschinski T, Bonnet F, Kehlet H; PROSPECT collaboration. Optimal pain management for radical prostatectomy surgery: what is the evidence? BMC Anesthesiol. 2015 Nov 4;15:159. doi: 10.1186/s12871-015-0137-2. PMID 26530113
- BACKGROUNDWheeler M, Oderda GM, Ashburn MA, Lipman AG. Adverse events associated with postoperative opioid analgesia: a systematic review. J Pain. 2002 Jun;3(3):159-80. doi: 10.1054/jpai.2002.123652. No abstract available. PMID 14622770
- BACKGROUNDMarcus HJ, Hughes-Hallett A, Payne CJ, Cundy TP, Nandi D, Yang GZ, Darzi A. Trends in the diffusion of robotic surgery: A retrospective observational study. Int J Med Robot. 2017 Dec;13(4):e1870. doi: 10.1002/rcs.1870. Epub 2017 Nov 6.