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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
476 stopped studies mapped to Malignant Ovarian Neoplasm and descendants · 86% state a reason
Over the 476 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT01275664 | Granisetron, Aprepitant, and Dexamethasone in Preventing Nausea and Vomiting in Patients… | N/A | terminated | Jan 12, 2011 | Gynecologic Oncology Group | Study terminated due to no patient population available | Other (stated, no rule matched) |
| NCT02412124 | Peer-to-Peer Support Program in Improving Quality of Life Outcomes in Patients With… | N/A | terminated | Apr 8, 2015 | City of Hope Medical Center | Feasibility issues | Other (stated, no rule matched) |
| NCT02833506 | Sirolimus and Vaccine Therapy in Treating Patients With Stage II-IV Ovarian, Fallopian… | Phase 1 | withdrawn | Jul 14, 2016 | Roswell Park Cancer Institute | production of adjuvant to be used with vaccine was discontinued by sponsor | Other (stated, no rule matched) |
| NCT00005029 | Topotecan in Treating Patients With Recurrent Ovarian Epithelial or Primary Peritoneal… | Phase 2 | terminated | Jul 19, 2004 | Gynecologic Oncology Group | not stated | Not stated |
| NCT01773889 | A Trial of Intravenous Denileukin Diftitox Plus Subcutaneous Pegylated IFNα-2A in Stage… | Phase 2 | terminated | Jan 23, 2013 | The University of Texas Health Science Center at San Antonio | Lack of funding | Funding |
| NCT02708511 | Copper Cu 64-DOTA-B-Fab PET/CT in Imaging Patients With Ovarian and Breast Cancer | Phase 1 | terminated | Mar 15, 2016 | Sanjiv Sam Gambhir | not stated | Not stated |
| NCT02110277 | Photoacoustic Imaging of the Ovary | N/A | terminated | Apr 10, 2014 | UConn Health | Dr Zhu, collaborator and the inventor of the photoacoustic system, is leaving the institution and… | Other (stated, no rule matched) |
| NCT00408070 | Bevacizumab Study With Carboplatin & Paclitaxel in Ovarian, Fallopian Tube or Primary… | Phase 2 | terminated | Dec 6, 2006 | UConn Health | Did not meet accrual goals. | Enrollment / accrual |
| NCT01936974 | (PGA) for Platinum-resistant/Refractory, Paclitaxel-Pretreated Recurrent Ovarian and…(PGA) | Phase 2 | terminated | Sep 6, 2013 | Western Regional Medical Center | PI Decision | Other (stated, no rule matched) |
| NCT00303888 | Docetaxel With or Without Phenoxodiol in Treating Patients With Recurrent Advanced… | Phase 1 | terminated | Mar 17, 2006 | Yale University | not stated | Not stated |
| NCT00574951 | AMG 706 in Treating Patients With Persistent or Recurrent Ovarian Epithelial Cancer,… | Phase 2 | terminated | Dec 17, 2007 | Gynecologic Oncology Group | Study was stopped for severe toxicity causing concern for patients | Safety / toxicity |
| NCT00585052 | A Phase II Study of Interaction of Lovastatin and Paclitaxel For Patients With Refractory… | Phase 2 | terminated | Jan 2, 2008 | University of Iowa | Slow accrual, PI left the institution | Investigator |
| NCT00720096 | Genomic Directed Salvage Chemotherapy With Either Liposomal Doxorubicin Or Topotecan | N/A | terminated | Jul 22, 2008 | H. Lee Moffitt Cancer Center and Research Institute | Funds for this project have been spent, and it is thereby terminated. | Funding |
| NCT00331422 | Carboplatin, Paclitaxel, and Surgery in Treating Patients With Advanced Ovarian… | Phase 2 | terminated | May 31, 2006 | Masonic Cancer Center, University of Minnesota | Study was terminated due to lack of available funding. | Funding |
| NCT00602446 | Deferasirox in Treating Patients With Iron Overload After Undergoing a Donor Stem Cell… | Phase 2 | terminated | Jan 28, 2008 | Masonic Cancer Center, University of Minnesota | Due to slow accrual of patients | Enrollment / accrual |
| NCT00652899 | Allogeneic Natural Killer Cells in Patients With Recurrent Ovarian Cancer, Fallopian… | Phase 2 | terminated | Apr 4, 2008 | Masonic Cancer Center, University of Minnesota | Withdrawn due to toxicity | Safety / toxicity |
| NCT00903630 | Lenalidomide and Doxorubicin Hydrochloride Liposome in Recurrent Ovarian Epithelial… | Phase 1 / Phase 2 | terminated | May 18, 2009 | Masonic Cancer Center, University of Minnesota | lack of funding | Funding |
| NCT00003532 | Antineoplaston Therapy in Treating Patients With Stage III or Stage IV Ovarian Cancer | Phase 2 | terminated | Jan 27, 2003 | Burzynski Research Institute | Slow accrual | Enrollment / accrual |
| NCT01281254 | AMG 386 (Trebananib) in Ovarian Cancer (TRINOVA-2) | Phase 3 | terminated | Jan 21, 2011 | Amgen | Closure of long term follow up (LTFU) and study earlier than previously outlined in the protocol as… | Other (stated, no rule matched) |
| NCT00003926 | Amifostine to Protect From Side Effects of PSCT in Treating Patients With Solid Tumors | Phase 1 | terminated | May 2, 2003 | Masonic Cancer Center, University of Minnesota | Withdrawn due to slow accrual | Enrollment / accrual |
| NCT00287859 | Topotecan in Treating Patients With Ovarian Epithelial, Fallopian Tube, or Primary… | Phase 1 | terminated | Feb 7, 2006 | Masonic Cancer Center, University of Minnesota | Withdrawn due to low accrual | Enrollment / accrual |
| NCT00562185 | Doxorubicin and Carboplatin in Treating Patients With Recurrent Ovarian Cancer | Phase 1 / Phase 2 | withdrawn | Nov 21, 2007 | University of Texas Southwestern Medical Center | Funding source withdrew funding | Funding |
| NCT03032614 | Combination of Carboplatin, Eribulin and Veliparib in Stage IV Cancer Patients | Phase 2 | withdrawn | Jan 26, 2017 | The University of Texas Health Science Center at San Antonio | Lack of funding | Funding |
| NCT02278783 | Phase 2 Trial of Regorafenib in Patients With Recurrent Ovarian, Primary Peritoneal and… | Phase 2 | terminated | Oct 30, 2014 | University of Utah | Slow Accrual | Enrollment / accrual |
| NCT00354601 | Docetaxel and Capecitabine in Treating Patients With Recurrent or Persistent Ovarian… | Phase 2 | terminated | Jul 20, 2006 | Wake Forest University Health Sciences | funding withdrawn | Funding |
| NCT01991210 | A Study of DNIB0600A in Comparison With Pegylated Liposomal Doxorubicin (PLD) in… | Phase 2 | terminated | Nov 25, 2013 | Genentech, Inc. | The primary objective of PFS did not meet pre-specified criteria. | Other (stated, no rule matched) |
| NCT00408967 | Determine if Either of 2 Doses of Study Drug Given With a Low-dose of Cyclophosphamide… | Phase 2 | withdrawn | Dec 8, 2006 | EMD Serono | Th trial got cancelled and no subjects signed informed consent form (ICF); study design not… | Other (stated, no rule matched) |
| NCT00004221 | Combination Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients… | Phase 2 | terminated | Aug 25, 2003 | Gynecologic Oncology Group | not stated | Not stated |
| NCT02093871 | A Phase 1 Trial of Perfusion Induced Systemic Hyperthermia (PISH) Over Multiple Cycles…(PISH-2) | Phase 1 | suspended | Mar 21, 2014 | ThermalCore Inc | not stated | Not stated |
| NCT00551265 | Oregovomab With or Without Cyclophosphamide in Treating Patients With Stage III or Stage… | N/A | withdrawn | Oct 30, 2007 | Gynecologic Oncology Group | not stated | Not stated |
| NCT00003865 | Toremifene in Treating Patients With Ovarian Cancer | Phase 2 | withdrawn | Jan 27, 2003 | George Washington University | not stated | Not stated |
| NCT01386502 | CT-011 and p53 Genetic Vaccine for Advanced Solid Tumors | Phase 1 | withdrawn | Jul 1, 2011 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT01972516 | Tivozanib As Maintenance Therapy In GYN | Phase 2 | terminated | Oct 30, 2013 | Dana-Farber Cancer Institute | due to slow accrual | Enrollment / accrual |
| NCT01681368 | Birinapant for Advanced Ovarian, Fallopian Tube, and Peritoneal Cancer | Phase 2 | terminated | Sep 7, 2012 | National Cancer Institute (NCI) | Accrual was terminated for lack of a clinical benefit. | Enrollment / accrual |
| NCT02417753 | AZD9150, a STAT3 Antisense Oligonucleotide, in People With Malignant Ascites | Phase 2 | terminated | Apr 16, 2015 | National Cancer Institute (NCI) | Study was closed because we could not find these types of patients. | Other (stated, no rule matched) |
| NCT00324324 | Moxifloxacin in Preventing Bacterial Infections in Patients Who Have Undergone Donor Stem… | Phase 3 | terminated | May 11, 2006 | OHSU Knight Cancer Institute | not stated | Not stated |
| NCT00900068 | Blood Samples From Patients on a Clinical Trial to CINV During HSCT | — | terminated | May 12, 2009 | OHSU Knight Cancer Institute | not stated | Not stated |
| NCT00603460 | DCVax-L Vaccination With CD3/CD28 Costimulated Autologous T-Cells for Recurrent Ovarian… | Phase 1 / Phase 2 | withdrawn | Jan 29, 2008 | University of Pennsylvania | not stated | Not stated |
| NCT02742428 | Preoperative Ascites Drainage Versus Standard Care for Patients With Advanced Ovarian… | N/A | suspended | Apr 19, 2016 | Gdynia Oncology Center | The protocol will be discussed and consulted. Potentially will resume. | Other (stated, no rule matched) |
| NCT01494012 | Phase I Stereotactic Body Radiation for Metastatic or Recurrent Platinum-Resistant… | Phase 1 | terminated | Dec 16, 2011 | Stanford University | low accrual | Enrollment / accrual |
| NCT02704650 | Identification and Characterization of Ovarian Cancer and Endometrial Cancer Specific… | N/A | withdrawn | Mar 10, 2016 | Shaare Zedek Medical Center | not stated | Not stated |
| NCT02567396 | Talazoparib in Treating Patients With Advanced or Metastatic Solid Tumors That Cannot Be… | Phase 1 | withdrawn | Oct 5, 2015 | National Cancer Institute (NCI) | Other- Protocol moved to Disapproved | Other (stated, no rule matched) |
| NCT01138137 | N-acetylcysteine Given IV With Cisplatin and Paclitaxel in Patients With Ovarian Cancer | Phase 1 | withdrawn | Jun 7, 2010 | OHSU Knight Cancer Institute | No funding was available for the cost of the IV N-acetylcysteine (NAC). | Funding |
| NCT00738699 | An Efficacy and Safety Study of MORAb-003 in Platinum-Resistant or Refractory Relapsed…(FAR-122) | Phase 2 | terminated | Aug 20, 2008 | Morphotek | study did not meet pre-specified criteria for continuation following interim futility analysis | Efficacy / futility |
| NCT02218502 | Study Into a New Diagnostic Tool (Simple Ultrasound-based Rules) in Patients With Adnexal…(SUBSONiC) | N/A | terminated | Aug 18, 2014 | Maastricht University Medical Center | interim analysis showed incorrect use of simple rules | Efficacy / futility |
| NCT01659554 | A Phase II Combined Modality Protocol of Debulking Surgery With HIPEC Followed by…(HIPEC) | Phase 2 | terminated | Aug 8, 2012 | Columbia University | Principal Investigator left institution | Investigator |
| NCT01137071 | Consolidation Therapy With Hu3S193 for Women With Ovarian, Primary Peritoneal or… | Phase 2 | terminated | Jun 4, 2010 | Recepta Biopharma | Total number of pts expected to be enrolled would not be met. | Enrollment / accrual |
| NCT01493505 | TRINOVA-3: A Study of AMG 386 or AMG 386 Placebo in Combination With Paclitaxel and… | Phase 3 | terminated | Dec 16, 2011 | Amgen | Amgen Administrative Decision - termination of LTFU | Other (stated, no rule matched) |
| NCT00946283 | Lactobacillus in Preventing Infection in Patients Undergoing a Donor Stem Cell Transplant… | N/A | terminated | Jul 24, 2009 | Rutgers, The State University of New Jersey | slow accrual | Enrollment / accrual |
| NCT00550654 | Conformal Radiation Therapy in Treating Patients With Metastatic Cancer Outside the Brain | Phase 2 | terminated | Oct 30, 2007 | National Institutes of Health Clinical Center (CC) | Study was terminated due to poor accrual. | Enrollment / accrual |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated May 22, 2018source: clinicaltrials