A Phase 1 Trial of Perfusion Induced Systemic Hyperthermia (PISH) Over Multiple Cycles for Terminal Ovarian Cancer

Inclusion Criteria:

* Age \>18 years
* Patients with ovarian cancer/primary peritoneal cancer of any histologic subtype, including epithelial, germ cell, sex-cord stromal, or sarcoma.
* Failure of first line surgery and chemotherapy, AND at least second line chemotherapy, with or without secondary cytoreductive surgeries
* Patients must be eligible for, and be expecting treatment by, an FDA approved chemotherapy regimen commonly used for their disease as per community standard.
* Female patients, aged 18-69 years old, and must be aware of the investigational nature of this treatment, and then indicate informed consent by the IRB-approved written process.
* All patients must have a performance status (Karnofsky score) greater than 80
* Patients may have been treated with radiotherapy, or non-chemotherapy anti-neoplastics (e.g. anti-angiogenic agents like bevicizumab)
* Hematologic Parameters: WBC of \> 4,000/μl with an ANC \>1500/μl, and a Platelet count of \>100,000/μl
* Renal Filtration: pretreatment measured or calculated creatinine clearance of \> 50 ml/minute by Cockroft-Gault equation or MDRD
* Electrolytes parameters: Patients pre-treatment serum calcium be in the normal (8.5-10.5 mg/dL) range.
* Liver function parameters: Bilirubin ≤ 1.5 times upper limit of normal (ULN); AST and ALT ≤ 2.5 times ULN; Alkaline phosphatase ≤ 2.5 times ULN; PT/INR ≤ 1.5 times ULN (or an in-range INR, usually between 2 and 3, if the patient is on a stable dose of therapeutic warfarin)

Exclusion Criteria:

* Patients who would be expected to receive benefit, on third recurrence, by a platinum-based regimen of chemotherapy
* Uncontrolled hypertension, defined as systolic BP \> 160 mm Hg or diastolic BP \> 100 mm Hg
* Myocardial infarction or unstable angina within the past 6 months
* NYHA class II-IV congestive heart failure
* Atrial fibrillation (AF) or Supra Ventricular Tachycardia (SVT) whether controlled by drugs or not; Any other serious arrhythmia, requiring medication to control
* Currently on anticoagulation for DVT or PE.
* Peripheral vascular disease ≥ CTCAE grade 2 (at least brief \[\< 24 hrs\] episodes of ischemia managed non-surgically and without permanent deficit)
* CNS metastases
* Lung disease, and a pulmonary function test (PFT) with FEV1 \<50% expected.
* Patients who have been treated with any chemotherapy or biologic therapy within the previous 21 days.
* Subjects who are unable or unwilling to comply with the follow-up schedule and requirements or sign informed consent