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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
547 stopped studies mapped to Malignant Nervous System Neoplasm and descendants · 90% state a reason
Over the 547 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT02039778 | Stem Cell Radiotherapy and Temozolomide for Newly Diagnosed High-grade Glioma(STRONG) | N/A | terminated | Jan 20, 2014 | Beth Israel Medical Center | Poor Accural | Other (stated, no rule matched) |
| NCT01310855 | Cediranib Maleate With or Without Gefitinib in Treating Patients With Recurrent or… | Phase 2 | terminated | Mar 9, 2011 | University College, London | closed to recruitment early due to AstraZeneca not developing cediranib further | Enrollment / accrual |
| NCT02648633 | Stereotactic Radiosurgery With Nivolumab and Valproate in Patients With Recurrent… | Phase 1 | terminated | Jan 7, 2016 | University of Virginia | The pharmaceutical company (BMS) would no longer provide nivolumab for the study, so the study was… | Sponsor / business decision |
| NCT00808899 | Neuroblastoma Protocol 2008: Therapy for Children With Advanced Stage High Risk… | Phase 2 | terminated | Dec 16, 2008 | St. Jude Children's Research Hospital | Voluntarily closed and terminated by the PI due to lack of feasibility | Other (stated, no rule matched) |
| NCT02129335 | Stress, Exercise Behavior and Survival in Patients With Newly Diagnosed Glioblastoma and…(TOGETHER) | — | terminated | May 2, 2014 | University Hospital, Basel, Switzerland | insufficient enrollment | Enrollment / accrual |
| NCT00324324 | Moxifloxacin in Preventing Bacterial Infections in Patients Who Have Undergone Donor Stem… | Phase 3 | terminated | May 11, 2006 | OHSU Knight Cancer Institute | not stated | Not stated |
| NCT00900068 | Blood Samples From Patients on a Clinical Trial to CINV During HSCT | — | terminated | May 12, 2009 | OHSU Knight Cancer Institute | not stated | Not stated |
| NCT01122901 | Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With… | Phase 2 | terminated | May 13, 2010 | National Cancer Institute (NCI) | Stopped prematurely by Company due to decision to terminate all CTEP supplied drug for further… | Sponsor / business decision |
| NCT02194452 | Efficacy of 68Ga-DOTATOC Positron Emission Tomography (PET) CT in Children and Young… | N/A | withdrawn | Jul 18, 2014 | Sue O'Dorisio | not stated | Not stated |
| NCT00710151 | Neurotoxicity in Primary Central Nervous System Lymphoma (PCNSL): An International… | — | terminated | Jul 4, 2008 | OHSU Knight Cancer Institute | not stated | Not stated |
| NCT01996527 | 3T MRI Biomarkers of Glioma Treatment Response | Early Phase 1 | terminated | Nov 27, 2013 | Vanderbilt-Ingram Cancer Center | PI left institution | Investigator |
| NCT02967380 | Gadobutrol Versus Gadopentetate Dimeglumine or Gadobenate Dimeglumine Before DCE-MRI in… | N/A | terminated | Nov 18, 2016 | University of Southern California | Insufficient Accrual | Enrollment / accrual |
| NCT02175745 | 18F-FDOPA PET/CT or PET/MRI in Measuring Tumors in Patients With Newly-Diagnosed or… | N/A | terminated | Jun 26, 2014 | Erik Mittra | Re-evaluate indication with the referring physicians | Other (stated, no rule matched) |
| NCT01944943 | Phase II Study of Vismodegib in Patients With Refractory or Relapsed B-cell Lymphoma or…(VISMOLY) | Phase 2 | terminated | Sep 18, 2013 | The Lymphoma Academic Research Organisation | lack of efficacy | Efficacy / futility |
| NCT01902771 | Dendritic Cell Vaccine Therapy With In Situ Maturation in Pediatric Brain Tumors | Phase 1 | terminated | Jul 18, 2013 | Edward Ziga | Lack of Accrual | Enrollment / accrual |
| NCT00456612 | Radiosurgery for Glioblastoma Multiforme | Phase 1 / Phase 2 | terminated | Apr 5, 2007 | Beth Israel Deaconess Medical Center | Poor accrual | Enrollment / accrual |
| NCT01642823 | Cancer Biology of Retinoblastoma | — | terminated | Jul 17, 2012 | Stanford University | Logistics | Other (stated, no rule matched) |
| NCT00947167 | A Phase II Study of Pertuzumab and Erlotinib for Metastatic or Unresectable… | Phase 2 | terminated | Jul 27, 2009 | Pamela L. Kunz | Extreme toxicity of Pertuzumab and Erlotinib combination | Safety / toxicity |
| NCT00980551 | Pilot Study of Topotecan/Vincristine With Subconjunctival Carboplatin for Patients With…(RELRB1) | N/A | withdrawn | Sep 21, 2009 | Children's Hospital Medical Center, Cincinnati | No enrollment and competing studies | Enrollment / accrual |
| NCT00582608 | Tumor Detection Using Iodine-131-Labeled Monoclonal Antibody 8H9 | N/A | terminated | Dec 28, 2007 | Memorial Sloan Kettering Cancer Center | Lack of accrual | Enrollment / accrual |
| NCT00171938 | Open-label Trial of Imatinib Mesylate in Patients With Unresectable Recurrent… | Phase 2 | terminated | Sep 15, 2005 | Novartis | not stated | Not stated |
| NCT02876003 | Efficacy and Safety of G-202 in PSMA-Positive Glioblastoma | Phase 2 | withdrawn | Aug 23, 2016 | GenSpera, Inc. | This study has been withdrawn prior to enrollment. | Enrollment / accrual |
| NCT01148966 | Aminolevulinic Acid During Surgery in Treating Patients With Malignant Brain Tumors | Phase 1 | terminated | Jun 23, 2010 | University of Washington | not stated | Not stated |
| NCT02025231 | Image Guided Reirradiation of High-grade Glioma | Phase 1 / Phase 2 | terminated | Dec 31, 2013 | Rigshospitalet, Denmark | Slow accrual | Enrollment / accrual |
| NCT02113007 | Study of High-Dose Rituximab With Temozolomide as Treatment for Primary Central Nervous… | Phase 2 | terminated | Apr 14, 2014 | SCRI Development Innovations, LLC | Closed early due to slow accrual. | Enrollment / accrual |
| NCT00946283 | Lactobacillus in Preventing Infection in Patients Undergoing a Donor Stem Cell Transplant… | N/A | terminated | Jul 24, 2009 | Rutgers, The State University of New Jersey | slow accrual | Enrollment / accrual |
| NCT01857752 | Phase II Study Temozolomide for Retinoblastoma Metastatic to the Central Nervous System… | Phase 2 | terminated | May 20, 2013 | Stanford University | accrual | Enrollment / accrual |
| NCT02394665 | Dose Escalated MRSI Guided Radiation Therapy in Glioblastoma | Phase 2 | terminated | Mar 20, 2015 | University of Miami | Lack of Accrual/Enrollment | Enrollment / accrual |
| NCT01204450 | Temsirolimus and Valproic Acid in Treating Young Patients With Relapsed Neuroblastoma,… | Phase 1 | terminated | Sep 17, 2010 | UNC Lineberger Comprehensive Cancer Center | Funding has become unavailable | Funding |
| NCT02841332 | Multimodal Imaging Analysis During Treatment With Bevacizumab in Patients With Recurrent…(IMAGLIO) | N/A | terminated | Jul 22, 2016 | University Hospital, Toulouse | lack of recruitment | Enrollment / accrual |
| NCT00473408 | The Effect of Radiotherapy and Temozolomide on the Tumor Vasculature and Stem Cells in…(Gliomstudien) | — | terminated | May 15, 2007 | Haukeland University Hospital | Moved to another country, not possible to recruit from abroad. | Enrollment / accrual |
| NCT02655432 | Performance of a Photoscreener for Vision Screening in a Haitian Pediatric Population(POPH) | — | withdrawn | Jan 14, 2016 | Université de Montréal | waiting for ethic board approval | Other (stated, no rule matched) |
| NCT02371031 | FDOPA-PET/MRI for the Pre-operative Evaluation of Gliomas | Phase 1 | terminated | Feb 25, 2015 | Washington University School of Medicine | Funding source for study ended. | Funding |
| NCT01113463 | TPI 287 in Patients With Recurrent Glioblastoma Multiforme | Phase 2 | terminated | Apr 30, 2010 | M.D. Anderson Cancer Center | Low Accrual | Enrollment / accrual |
| NCT00574964 | Gliadel Wafers and Temodar in the Treatment of Glioblastoma Multiforme(Temodar) | Phase 2 | terminated | Dec 17, 2007 | University of Iowa | PI left the institution. | Investigator |
| NCT02047747 | A Phase II Study of Dacomitinib in Progressive Brain Metastases | Phase 2 | terminated | Jan 28, 2014 | David Piccioni, M.D., Ph.D | slow enrollment | Enrollment / accrual |
| NCT02370563 | PET Imaging of Intracranial Cancers With 18F-FSPG | Phase 1 | terminated | Feb 25, 2015 | Lantheus Biosciences Ltd. | Business decision | Sponsor / business decision |
| NCT01105702 | Temodar (Temozolomide), Bevacizumab, Lithium and Radiation for High Grade Glioma | Phase 2 | terminated | Apr 16, 2010 | NYU Langone Health | Due to slow accrual | Enrollment / accrual |
| NCT01989052 | Ph 1/2 CTO With Lomustine for Bevacizumab-Naive Recurrent Glioma | Phase 1 | terminated | Nov 20, 2013 | Annick Desjardins | This study was terminated early due to funding issues prior to completion of phase I | Funding |
| NCT01393769 | Intra-arterial Chemotherapy With Melphalan for the Treatment of Retinoblastoma (RTB) in… | Phase 2 | terminated | Jul 13, 2011 | Hospital Sant Joan de Deu | Only 5 subjects could be enrolled. Sample of 25 pat. not be achieved (rare disease). | Enrollment / accrual |
| NCT01163539 | Cyberknife Radiosurgery and Quality of Life | — | terminated | Jul 15, 2010 | Stanford University | not stated | Not stated |
| NCT00670410 | Autologous Transplant Followed by Allogeneic Transplant for High Risk Neuroblastoma | Phase 1 | terminated | May 1, 2008 | Columbia University | Poor accrual | Enrollment / accrual |
| NCT01048086 | 90Y DOTA/Retinoic Acid for Neuroblastoma and Neuroendocrine Tumor (NET) | Phase 2 | withdrawn | Jan 13, 2010 | University of Iowa | No patients were enrolled because the company that pledged the drug does not yet have it available. | Enrollment / accrual |
| NCT02060955 | Randomized Phase 2 Study to Investigate Efficacy of ALECSAT in Patients With GBM Measured… | Phase 2 | terminated | Feb 12, 2014 | CytoVac A/S | Substantial design modifications required. | Other (stated, no rule matched) |
| NCT02031965 | Oncolytic HSV-1716 in Treating Younger Patients With Refractory or Recurrent High Grade… | Phase 1 | terminated | Jan 9, 2014 | Pediatric Brain Tumor Consortium | not stated | Not stated |
| NCT01445691 | More Complete Removal of Malignant Brain Tumors by Fluorescence-Guided Surgery | Phase 2 | withdrawn | Oct 4, 2011 | Constantinos Hadjipanayis | not stated | Not stated |
| NCT01499251 | Clinical Study on the Safety and Tolerability of Macitentan in Combination With… | Phase 1 | terminated | Dec 26, 2011 | Actelion | Results did not clearly support continuing development in recurrent GBM | Other (stated, no rule matched) |
| NCT01351519 | A Study of Aminolevulinic Acid Used to Enhance Visualization and Surgical Removal of… | Phase 2 | terminated | May 11, 2011 | MultiCare Health System Research Institute | Limited staff available for enrollment and limited availability of drug | Enrollment / accrual |
| NCT01830101 | A Phase III Study of Re-Irradiation in Recurrent Glioblastoma | Phase 3 | withdrawn | Apr 12, 2013 | AHS Cancer Control Alberta | This study will not be proceeding due to lack of funding from anticipated sources | Funding |
| NCT01249105 | MK-2206 for Recurrent Malignant Glioma | Phase 2 | withdrawn | Nov 29, 2010 | Dana-Farber Cancer Institute | Merck (supplier of study drug \& funding) has undergone a large reprioritization, in which they had… | Funding |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Jun 5, 2017source: clinicaltrials