Clinical trial · Observational
Cancer Biology of Retinoblastoma
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): Logistics
Summary
Brief summary (as posted)
Many children with the childhood cancer, Retinoblastoma, have surgery to remove the tumor and sometimes the entire eye. The purpose of this study is to collect the extra tissue from patients who undergo tumor removal for laboratory experiments that will help us understand not only what occurs in retinoblastoma cells but also how cells normally function. Some of these studies will include an evaluation of how cells control the way that genes are expressed, how cells "know" to become retinal cells, how cells remain retinal cells, how cells lose their identity as retinal cells, what changes make retinoblastoma cells different from normal retinal cells, and what changes make some retinoblastomas worse than others.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Retinoblastoma | Retinoblastoma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (1)
- label
- retinablastoma tumor tissue
Primary outcomes (1)
- measure
- Change in efficiency of reprogramming in cells with "naturally occurring" retinoblastoma mutations
- timeFrame
- After appropriate time, e.g., 7, 10, 14 days after reprogramming
- description
- Comparison of number of reprogramming events (defined by colony formation assay and normalized for number of cell plated) as well as the time to reprogramming.
Eligibility
Eligibility (as posted)
- Sex
- All
- Maximum age
- 5 Years
Show eligibility criteria text
Inclusion Criteria: * Patient must have retinoblastoma * Patient must be receiving biopsy, partial surgical excision of the tumor, complete excision of the tumor, or enucleation of the eye as part of their standard care. * Parental consent Exclusion Criteria: * Diagnosis other than Retinoblastoma * No surgical sampling of tumor is planned as part of standard care * Parental preference to not participate.
References
Publications (0)
Data not yet available