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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
2,061 stopped studies mapped to Malignant Neoplasm of Unknown Primary and descendants · 91% state a reason
Over the 2,061 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT01492920 | Acetyl-L-Carnitine Hydrochloride in Preventing Peripheral Neuropathy in Patients With… | Phase 3 | withdrawn | Dec 15, 2011 | Gynecologic Oncology Group | Withdrawn | Other (stated, no rule matched) |
| NCT00352859 | Phase IV Randomization to On-Going Treatment to Evaluate Sustained Sorafenib | Phase 4 | terminated | Jul 17, 2006 | Bayer | not stated | Not stated |
| NCT00072137 | Neoadjuvant Intravesical Vaccine Therapy in Treating Patients With Bladder Carcinoma Who… | Phase 1 | terminated | Nov 6, 2003 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00622479 | Mechanistic Evaluation on Sorafenib Induced Hypophosphatemia. | Phase 1 | terminated | Feb 25, 2008 | Bayer | not stated | Not stated |
| NCT00678288 | A Study to Assess Sorafenib Alone and in Combination With Low-Dose Interferon Following… | Phase 2 | terminated | May 15, 2008 | Bayer | not stated | Not stated |
| NCT01838265 | Trial of Prostate Cancer Patients Undergoing Active Surveillance With or Without…(MGM) | — | withdrawn | Apr 24, 2013 | University of Miami | Unlikely to Accrue | Enrollment / accrual |
| NCT01666431 | Single-center Investigator Initiated Pilot Study Investigating the Tumor Response of… | Phase 2 | terminated | Aug 16, 2012 | University of Zurich | not stated | Not stated |
| NCT02070419 | TACE With or Without Radiation Therapy in Treating Patients With Stage A-C Liver Cancer | Phase 2 | withdrawn | Feb 25, 2014 | Case Comprehensive Cancer Center | Principal Investigator left institution | Investigator |
| NCT01465815 | Phase I/II Study of Postoperative Adjuvant Chemoradiation for Advanced-Stage Cutaneous… | Phase 1 / Phase 2 | withdrawn | Nov 7, 2011 | OHSU Knight Cancer Institute | Drug manufacturer, Astellas Pharma, informed us that safety and efficacy of Erlotinib and OSI-906… | Safety / toxicity |
| NCT01254734 | Transoral Robotic Surgery in Treating Patients With Benign or Stage I-IV Head and Neck… | N/A | terminated | Dec 7, 2010 | City of Hope Medical Center | The study will be rewritten as a data registry study | Other (stated, no rule matched) |
| NCT01088763 | Gamma-Secretase Inhibitor RO4929097 in Treating Young Patients With Relapsed or… | Phase 1 | terminated | Mar 17, 2010 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT01313663 | A Study to Evaluate Pazopanib in Comparison to Pemetrexed in Maintenance Setting in… | Phase 2 | terminated | Mar 14, 2011 | GlaxoSmithKline | not stated | Not stated |
| NCT00808145 | Study of Sorafenib, Gemcitabine, and Cisplatin in Advanced Hepatocellular Carcinoma (HCC) | Phase 2 | withdrawn | Dec 15, 2008 | Lahey Clinic | Lack of enrollment, many screen failures and non eligible study participants | Enrollment / accrual |
| NCT01791998 | Magnetic Resonance Thermal Image Guided Laser Interstitial Thermal Therapy in Treating… | N/A | withdrawn | Feb 15, 2013 | University of Chicago | Funding was time sensitive and expired. No subjects enrolled. | Enrollment / accrual |
| NCT02254044 | Dose Escalation of Bivatuzumab Mertansine in Patients With Advanced Squamous Cell… | Phase 1 | terminated | Oct 1, 2014 | Boehringer Ingelheim | not stated | Not stated |
| NCT00892242 | Perioperative Treatment With Zoledronic Acid in Patients With Resectable Pancreas Cancer | Phase 1 | terminated | May 4, 2009 | Washington University School of Medicine | Principal Investigator decided to close the study early. | Investigator |
| NCT01943058 | Megestrol Acetate or Levonorgestrel-Releasing Intrauterine System in Treating Patients… | Phase 2 | withdrawn | Sep 16, 2013 | University of Southern California | Lack of funding | Funding |
| NCT01859182 | Selumetinib and Akt Inhibitor MK-2206 in Treating Patients With Refractory or Advanced… | Phase 2 | withdrawn | May 21, 2013 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT01872988 | Tenofovir Antiviral Therapy Following Transarterial Chemoembolization for HBV Related… | Phase 3 | terminated | Jun 7, 2013 | Taichung Veterans General Hospital | Difficult in patient enrollment | Enrollment / accrual |
| NCT01718223 | Photodynamic Therapy Using Temoporfin Before Surgery in Treating Patients With Recurrent… | N/A | withdrawn | Oct 31, 2012 | Roswell Park Cancer Institute | implementation issues | Other (stated, no rule matched) |
| NCT01305772 | Identification of Gene Expression Signature for Panitumumab Sensitivity in Untreated…(TOP0901) | Phase 2 | terminated | Mar 1, 2011 | Neal Ready | This study was terminated for low accrual. | Enrollment / accrual |
| NCT01682031 | Selenomethionine in Reducing Mucositis in Patients With Locally Advanced Head and Neck… | Phase 2 | terminated | Sep 10, 2012 | Roswell Park Cancer Institute | Due to a lack of funding | Funding |
| NCT01175499 | Concordance of Two Endoscopic Procedures for Diagnosis of Carcinoma of the Upper…(TNFE-NBI) | N/A | withdrawn | Aug 4, 2010 | University of California, San Francisco | Unable to obtain funding to continue recruitment; no accrual | Enrollment / accrual |
| NCT00911326 | Evaluation of Sentinel Lymph Nodes in Head and Neck Squamous Cell Carcinoma | Phase 3 | terminated | Jun 1, 2009 | Navidea Biopharmaceuticals | The trial was terminated early based on an interim review by the Data and Safety Monitoring… | Safety / toxicity |
| NCT00001703 | Vaccine Therapy With Tumor Specific Mutated VHL Peptides in Adult Cancer Patients With… | Phase 2 | terminated | Nov 4, 1999 | National Cancer Institute (NCI) | Due to poor accrual and lack of peptide vaccine | Enrollment / accrual |
| NCT01227018 | PhII Study STA-9090 as Second or Third-Line Therapy for Metastatic Pancreas Cancer | Phase 2 | terminated | Oct 22, 2010 | Vanderbilt-Ingram Cancer Center | interim analysis found the study drug to be ineffective | Efficacy / futility |
| NCT01722175 | Associating Liver Partition With Portal Vein Ligation For Staged Hepatectomy (ALPPS) or…(ALPPS) | Phase 2 | withdrawn | Nov 6, 2012 | Washington University School of Medicine | Safety concerns. | Safety / toxicity |
| NCT01669668 | Radiofrequency Ablation in Treating Patients With Liver Cancer (Hepatocellular Carcinoma) | Phase 2 | withdrawn | Aug 21, 2012 | Washington University School of Medicine | Lack of referrals. | Other (stated, no rule matched) |
| NCT01491633 | Dasatinib in Advanced Squamous Cell Lung Cancer | Phase 2 | terminated | Dec 14, 2011 | Dana-Farber Cancer Institute | Safety issues/concerns per DF/HCC PI | Safety / toxicity |
| NCT01301612 | Study of Nimotuzumab, Radiation Therapy and Cisplatin Versus Radiation Therapy and… | Phase 2 | withdrawn | Feb 23, 2011 | Eurofarma Laboratorios S.A. | Regulatory requirement. A phase III study is being designed. | Other (stated, no rule matched) |
| NCT01187615 | Determination of Safety, Efficacy, and Pharmacokinetics of "Regorafenib" Combined With… | Phase 1 | terminated | Aug 24, 2010 | Bayer | not stated | Not stated |
| NCT00002947 | Indium In 111 Pentetreotide in Treating Patients With Refractory Cancer | Phase 1 | terminated | Mar 26, 2004 | Yale University | not stated | Not stated |
| NCT01432314 | Efficacy of Radiation Therapy and Transarterial Chemoembolization (TACE) to Treat…(RTANDTACE) | Phase 2 | withdrawn | Sep 12, 2011 | Asan Medical Center | Another phase 2 randomized study has been started by other investigators. | Other (stated, no rule matched) |
| NCT01793636 | A Study Comparing AZD2014 vs Everolimus in Patients With Metastatic Renal Cancer(ZEBRA) | Phase 2 | terminated | Feb 15, 2013 | Queen Mary University of London | Inferior efficacy of study drug in renal indication. | Efficacy / futility |
| NCT01360827 | EMD 1201081 + 5-FU + Cisplatin + Cetuximab in Subjects With Recurrent / Metastatic… | Phase 1 | terminated | May 26, 2011 | Merck KGaA, Darmstadt, Germany | Study terminated due to potential safety concerns in combination with platinum-based therapies | Safety / toxicity |
| NCT00079326 | Trastuzumab and Ixabepilone in Treating Women With HER2-Positive Metastatic Breast Cancer | Phase 2 | terminated | Mar 10, 2004 | National Cancer Institute (NCI) | Slow accrual. | Enrollment / accrual |
| NCT01365143 | Prospective Randomized Trial Comparing Robotic Versus Open Radical Prostatectomy | Phase 4 | terminated | Jun 3, 2011 | Mayo Clinic | Closing due to slow enrollment | Enrollment / accrual |
| NCT00112905 | Sorafenib in Treating Patients With Regional or Metastatic Cancer of the Urothelium | Phase 2 | terminated | Jun 3, 2005 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT01741597 | Dynamic Contrast Enhanced MRI in Patients With Advanced Breast or Pancreatic Cancer With… | Phase 1 | withdrawn | Dec 5, 2012 | City of Hope Medical Center | PI chose to close the study | Other (stated, no rule matched) |
| NCT00084487 | Rebeccamycin Analog as Second-Line Therapy in Treating Patients With Limited-Stage or… | Phase 2 | terminated | Jun 11, 2004 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00835679 | Cetuximab and/or Dasatinib in Patients With Colorectal Cancer and Liver Metastases That… | Early Phase 1 | terminated | Feb 4, 2009 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00303862 | AZD2171 in Treating Patients With Refractory Metastatic Kidney Cancer | Phase 2 | terminated | Mar 17, 2006 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT01329640 | Feasibility Study of Metronomic Chemotherapy for Locally Advanced Her2- Positive Breast… | Phase 2 | terminated | Apr 6, 2011 | Instituto do Cancer do Estado de São Paulo | not stated | Not stated |
| NCT01963949 | Prospective, Observational Study of Biomarkers in Liver Cancer - Identification of… | — | withdrawn | Oct 17, 2013 | University of Texas Southwestern Medical Center | not stated | Not stated |
| NCT00493428 | Treatment of Non-Metastatic Hepatocellular Carcinoma in Humans by Increasing Gabaergic… | Phase 2 | withdrawn | Jun 28, 2007 | University of Manitoba | The study have been stoped because the protocol is going to be modify. | Other (stated, no rule matched) |
| NCT00684996 | Bevacizumab With or Without MEDI-522 in Treating Patients With Unresectable or Metastatic… | Phase 1 / Phase 2 | terminated | May 28, 2008 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00023946 | BMS-247550 in Treating Patients With Liver or Gallbladder Cancer | Phase 2 | terminated | Jan 27, 2003 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00778817 | IMC-A12 With Mitotane vs Mitotane Alone in Recurrent, Metastatic, or Primary ACC That… | Phase 2 | terminated | Oct 23, 2008 | National Cancer Institute (NCI) | The trial was permanently halted due to futility concerns. | Efficacy / futility |
| NCT01233505 | Veliparib, Oxaliplatin, and Capecitabine in Treating Patients With Advanced Solid Tumors | Phase 1 | terminated | Nov 3, 2010 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00088933 | Vaccine Therapy and Sargramostim With or Without Docetaxel in Treating Patients With… | Phase 1 | terminated | Aug 5, 2004 | National Cancer Institute (NCI) | not stated | Not stated |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Dec 31, 2014source: clinicaltrials