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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
12,383 stopped studies mapped to Malignant Neoplasm and descendants · 89% state a reason
Over the 12,383 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT00385775 | Study of XIAP Antisense for Advanced Cancers | Phase 1 | terminated | Oct 11, 2006 | Aegera Therapeutics | Dosing cohort (650mg) exceeded current 350mg dosing in other trials. | Other (stated, no rule matched) |
| NCT00115453 | Boron Neutron Capture Therapy (BNCT) as Treatment of Glioblastoma | Phase 1 / Phase 2 | terminated | Jun 23, 2005 | Boneca Corporation | Slow accrual | Enrollment / accrual |
| NCT00147485 | A Phase 1 Study Of An Intravenously Administered Cyclin-Dependent Kinase Inhibitor In… | Phase 1 | terminated | Sep 7, 2005 | Pfizer | See Detailed Description | Other (stated, no rule matched) |
| NCT00155883 | Bi-Weekly Docetaxel Plus 24-Hour Infusion of High-Dose 5-Fluorouracil / Leucovorin (HDFL)… | Phase 2 | terminated | Sep 12, 2005 | National Taiwan University Hospital | slow a accrul due to many competitive trials. | Enrollment / accrual |
| NCT00161278 | Pilot Study for the Determination of Tumor Response to Chemotherapy in Advanced NSCLC… | Phase 2 | terminated | Sep 12, 2005 | University of Michigan Rogel Cancer Center | recruitment has ended | Enrollment / accrual |
| NCT00239200 | Lapatinib (GW572016) for Metastatic or Recurrent Squamous Cell Carcinoma Esophagus | Phase 2 | terminated | Oct 14, 2005 | University of Michigan Rogel Cancer Center | notification from sponsor | Other (stated, no rule matched) |
| NCT00606879 | Safety Study of SGX523, a Small Molecule Met Inhibitor, to Treat Solid Tumors | Phase 1 | terminated | Feb 5, 2008 | SGX Pharmaceuticals, Inc. | not stated | Not stated |
| NCT00607399 | Safety Study of SGX523, a Small Molecule Met Inhibitor, to Treat Solid Tumors | Phase 1 | terminated | Feb 5, 2008 | SGX Pharmaceuticals, Inc. | not stated | Not stated |
| NCT00535015 | Safety and Efficacy Study of Betamarc to Treat Loss of Weight and Appetite in Non-Small… | Phase 2 | terminated | Sep 26, 2007 | Anaborex | Objectives of study could not be met within a reasonable timeframe. | Other (stated, no rule matched) |
| NCT00162812 | Topoisomerase II Alpha Gene Amplification and Protein Overexpression Predicting Efficacy…(TOP) | Phase 2 | terminated | Sep 13, 2005 | Jules Bordet Institute | Low accrual rate | Enrollment / accrual |
| NCT00607425 | Saliva mRNA Expression Profiling for Early Stage Non-Small Cell Lung Cancer Screening(SPIT-LC) | — | terminated | Feb 5, 2008 | Scottsdale Healthcare | Change in isolation method | Other (stated, no rule matched) |
| NCT00148018 | Study of Bortezomib (Velcade) in Combination With Dexamethasone to Treat Patients With… | Phase 2 | terminated | Sep 7, 2005 | University of Cologne | not stated | Not stated |
| NCT00419978 | The Significance of Sentinel Node Analysis in Colon Cancer | N/A | terminated | Jan 9, 2007 | Legacy Health System | Slow accrural to study. | Enrollment / accrual |
| NCT00451945 | New Indications for Ultrasound in the Staging of Cervical Cancer | N/A | withdrawn | Mar 26, 2007 | Rigshospitalet, Denmark | not stated | Not stated |
| NCT00200668 | Comparison Between FDG-PET and MRI for the Assessment of Response to Intensive… | N/A | terminated | Sep 20, 2005 | Nantes University Hospital | not stated | Not stated |
| NCT00399009 | Comparative Study of Circular Stapling Instruments | N/A | terminated | Nov 14, 2006 | Uppsala University Hospital | One of the instruments in the study was withdrawn from the market before the calculated number of… | Other (stated, no rule matched) |
| NCT00635063 | A Multicentre Study to Evaluate the Safety and Efficacy of AD 923 in Comparison to MSIR… | Phase 3 | terminated | Mar 13, 2008 | Sosei | Termination is due to a combination of a device defect potentially impacting the quality of the AD… | Sponsor / business decision |
| NCT00457327 | Pilot Study for Evaluation of the Need for Protective Ileostomy After Low Anterior… | Phase 2 | terminated | Apr 6, 2007 | Heidelberg University | RCT with same hypothesis ended and showed a superiority for protective ileostomy after lower… | Other (stated, no rule matched) |
| NCT00234481 | Safety Study of XL844 in Subjects With Chronic Lymphocytic Leukemia | Phase 1 | terminated | Oct 7, 2005 | Exelixis | Study closed due to slow enrollment | Enrollment / accrual |
| NCT00460278 | Study of XL418 in Adults With Solid Tumors | Phase 1 | suspended | Apr 13, 2007 | Exelixis | Enrollment suspended due to low drug exposure. | Enrollment / accrual |
| NCT00363610 | A Study Evaluating IV Oncaspar® and IV Gemzar® in the Treatment of Solid Tumors and… | Phase 1 | terminated | Aug 15, 2006 | Enzon Pharmaceuticals, Inc. | No recommended Phase II dose was determined. | Other (stated, no rule matched) |
| NCT00358566 | GV1001 and Gemcitabine in Sequential Combination to Gemcitabine Monotherapy in Pancreatic… | Phase 3 | terminated | Aug 1, 2006 | Pharmexa A/S | Preliminary data showed no survival benefit in the GV1001 group compared to the gemcitabine group. | Other (stated, no rule matched) |
| NCT00443573 | Safety Study of Recombinant NAPc2 to Prevent Tumor Progression and Metastases in… | Phase 1 / Phase 2 | suspended | Mar 6, 2007 | ARCA Biopharma, Inc. | Company suspended development of product. | Sponsor / business decision |
| NCT00440934 | A Study of Electromagnetic Waves in the Treatment of the Advanced Hepatocarcinoma(THBC002) | Phase 2 | terminated | Feb 27, 2007 | Pasche, Boris, M.D. | Poor patient accrual | Enrollment / accrual |
| NCT00216814 | Antiangiogenic Effects of BCG on Urinary Concentration of Angiogenic Factors | — | terminated | Sep 22, 2005 | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | No funding and data was not appropriate to consider continuing. | Funding |
| NCT00250861 | Trial of Outpatient Immunotherapy With Rituximab and Aldesleukin (IL-2) vs. Rituximab… | Phase 2 | terminated | Nov 8, 2005 | US Oncology Research | Study terminated due to lack of enrollment. | Enrollment / accrual |
| NCT00461344 | Docetaxel + Doxorubicin as Neoadjuvant Chemotherapy in Patients With Breast Cancer | Phase 2 | terminated | Apr 18, 2007 | Sanofi | due to slow recruitment of patients | Enrollment / accrual |
| NCT00146029 | Companion Pharmacogenetic Study to UMCC 9900/9901 | — | terminated | Sep 5, 2005 | University of Michigan Rogel Cancer Center | not stated | Not stated |
| NCT00644306 | Comparison of Melphalan-Prednisone (MP) to MP Plus Thalidomide in the Treatment of Newly…(IFM 01/01) | Phase 3 | terminated | Mar 26, 2008 | Central Hospital, Nancy, France | survival advantage demonstrated | Other (stated, no rule matched) |
| NCT00263016 | Docetaxel in Non Small Cell Lung Cancer (NSCLC) | Phase 2 | terminated | Dec 7, 2005 | Sanofi | Slow recruitment | Enrollment / accrual |
| NCT00302861 | A Study to Evaluate the Treatment of Previously Untreated B-Cell Chronic Lymphocytic… | Phase 1 / Phase 2 | terminated | Mar 15, 2006 | Genitope Corporation | not stated | Not stated |
| NCT00510471 | Personalized Active Immunotherapy (Vaccine Therapy) and Sargramostim Given After Standard… | Phase 2 | terminated | Aug 2, 2007 | Genitope Corporation | not stated | Not stated |
| NCT00630903 | PUVA Versus PUVA + IFN Alpha 2a in Mycosis Fungoides(MF99) | Phase 4 | terminated | Mar 7, 2008 | Madrilenian Group of Cutaneous Lymphomas | Insufficient accrual | Enrollment / accrual |
| NCT00363025 | A Randomized Study of Post-Remission Therapy in Elderly Patients With Acute Myelogenous… | Phase 3 | terminated | Aug 15, 2006 | Acute Leukemia French Association | not stated | Not stated |
| NCT00517218 | This Study is Being Performed to Evaluate the Effect of Genasense on the Efficacy and the… | Phase 3 | withdrawn | Aug 16, 2007 | Genta Incorporated | not stated | Not stated |
| NCT00098917 | Vaccine Therapy in Treating Patients Who Are Undergoing Surgery for Stage IB, Stage II,… | Phase 1 | terminated | Dec 9, 2004 | Jonsson Comprehensive Cancer Center | not stated | Not stated |
| NCT00265928 | Bortezomib and Rituximab in Treating Patients With Relapsed or Refractory B-Cell… | Phase 2 | terminated | Dec 15, 2005 | University of Virginia | Withdrawn for poor accrual | Enrollment / accrual |
| NCT00104468 | Study of Troxatyl™ Administered by Continuous Infusion to Subjects With Refractory Acute… | Phase 1 / Phase 2 | terminated | Mar 1, 2005 | SGX Pharmaceuticals, Inc. | Trial stopped June 2007 | Other (stated, no rule matched) |
| NCT00141700 | Study of Rituximab Plus High-Dose Chemotherapy Poor Prognosis Non-Hodgkin's Lymphoma | Phase 2 | terminated | Sep 1, 2005 | University of Michigan Rogel Cancer Center | enrollment completed | Enrollment / accrual |
| NCT00148135 | Combination of Carboplatin, Gemcitabine, and Capecitabine in Patients With Carcinoma of… | Phase 2 | terminated | Sep 7, 2005 | University of Michigan Rogel Cancer Center | recruitment goals met | Enrollment / accrual |
| NCT00176787 | Radiation Therapy With Capecitabine in Rectal Cancer | Phase 2 | terminated | Sep 15, 2005 | University of Michigan Rogel Cancer Center | recruitment goals met | Enrollment / accrual |
| NCT00346099 | Study of Panitumumab Given First With Capecitabine and Oxaliplatin (CAPOX) and Then With… | Phase 2 | withdrawn | Jun 29, 2006 | NSABP Foundation Inc | Protocol closed based on new (and as yet unpublished) information from a phase II clinical trial. | Other (stated, no rule matched) |
| NCT00197925 | Dendritic Cell Based Therapy of Metastatic Breast Cancer | Phase 1 / Phase 2 | terminated | Sep 20, 2005 | Herlev Hospital | all patients recruited | Enrollment / accrual |
| NCT00077493 | BL22 Immunotoxin In Treating Young Patients With Relapsed or Refractory Acute… | Phase 1 | suspended | Feb 12, 2004 | MedImmune LLC | protocol development and Amended protocol revision | Other (stated, no rule matched) |
| NCT00165087 | Treatment of Childhood Acute Lymphoblastic Leukemia | Phase 3 | terminated | Sep 14, 2005 | Dana-Farber Cancer Institute | Terminated by IRB for continuing review | Other (stated, no rule matched) |
| NCT00417677 | A Study Combining Treatment With Temsirolimus and Sunitinib for Subjects With Advanced… | Phase 1 / Phase 2 | terminated | Jan 4, 2007 | Wyeth is now a wholly owned subsidiary of Pfizer | Decision was made not to attempt a lower dose | Other (stated, no rule matched) |
| NCT00165581 | High Dose Rate Intracavitary Brachytherapy as the Sole Method of Radiation Therapy for… | N/A | terminated | Sep 14, 2005 | Dana-Farber Cancer Institute | Due to continuing review | Other (stated, no rule matched) |
| NCT00121745 | Evaluation of Safety of Rexin-G Gene Transfer for Advanced Pancreatic Cancer | Phase 1 | terminated | Jul 21, 2005 | Epeius Biotechnologies | poor enrollment | Enrollment / accrual |
| NCT00050375 | Clinical Trial for Ovarian Cancer (OvaRex®) | Phase 3 | terminated | Dec 6, 2002 | Unither Pharmaceuticals | Study closed by sponser | Other (stated, no rule matched) |
| NCT00086632 | Study of Ovarex® (Oregovomab) MAb With Front-Line Chemotherapy for Ovarian Cancer… | Phase 2 | terminated | Jul 9, 2004 | Unither Pharmaceuticals | closed by sponser | Other (stated, no rule matched) |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Aug 21, 2008source: clinicaltrials