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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
12,388 stopped studies mapped to Malignant Neoplasm and descendants · 89% state a reason
Over the 12,388 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT01034410 | A Study of AS1411 Combined With Cytarabine in the Treatment of Patients With Primary… | Phase 2 | terminated | Dec 17, 2009 | Antisoma Research | not stated | Not stated |
| NCT00050687 | Safety and Pharmacokinetics of Orally Administered Gallium Maltolate in Various… | Phase 1 / Phase 2 | terminated | Dec 19, 2002 | Titan Pharmaceuticals | not stated | Not stated |
| NCT00252811 | A Study of ZD1839 Effects on Cell Proliferation in Breast Cancer | Phase 2 | withdrawn | Nov 15, 2005 | AstraZeneca | not stated | Not stated |
| NCT00003365 | Sulindac and Plant Compounds in Preventing Colon Cancer | N/A | terminated | May 21, 2004 | University of Medicine and Dentistry of New Jersey | Study completed | Other (stated, no rule matched) |
| NCT00233623 | Irinotecan, 5-Fluorouracil and Leucovorin With or Without Iressa in the Treatment of… | Phase 2 | withdrawn | Oct 6, 2005 | AstraZeneca | not stated | Not stated |
| NCT00233636 | Iressa and Radiotherapy in the Treatment of the Locally Advanced Inoperable Squamous Cell… | Phase 2 | withdrawn | Oct 6, 2005 | AstraZeneca | not stated | Not stated |
| NCT00065572 | Exploratory Study to Assess the Biological Activity of ZD6126 in Subjects With Newly… | Phase 2 | suspended | Jul 31, 2003 | AstraZeneca | not stated | Not stated |
| NCT00460460 | Phase I, Open-label, Dose Escalation of AZD4877 in Hematologic Malignancies | Phase 1 | terminated | Apr 16, 2007 | AstraZeneca | Study was terminated due to low enrollment | Enrollment / accrual |
| NCT00577356 | Docetaxel and Immunotherapy Prior to Prostatectomy for High-Risk Prostate Cancer | Phase 2 | terminated | Dec 20, 2007 | Benaroya Research Institute | Safety reasons, though no safety issues arose. | Safety / toxicity |
| NCT00749255 | Collect Breast Cancer Patients' Digital Mammography Images With Corresponding Reports for… | — | terminated | Sep 9, 2008 | WellSpan Health | not enough personnel to conduct study at site | Other (stated, no rule matched) |
| NCT00003113 | Oral Combination Chemotherapy in Treating Elderly Patients With Intermediate or… | Phase 2 | terminated | Sep 24, 2003 | Case Comprehensive Cancer Center | not stated | Not stated |
| NCT00531778 | NYU Ovarian Cancer Early Detection Program Blood and Genetics | — | terminated | Sep 19, 2007 | NYU Langone Health | insufficient funding and resource | Funding |
| NCT00354562 | A Phase 2 Study Evaluating ABT-751 in Combination With Taxotere in Advanced Non-Small… | Phase 1 / Phase 2 | terminated | Jul 20, 2006 | Abbott | not stated | Not stated |
| NCT00651443 | Mechanism of Action of Galiximab in Subjects With Previously Untreated Follicular… | Phase 1 | terminated | Apr 2, 2008 | Biogen | A company's strategic decision to focus on areas whereit believes it can be competitive and decided… | Sponsor / business decision |
| NCT01271166 | Glivec® Plus m-FOLFOX Avastin® in Advanced Colorectal Cancer | Phase 1 | terminated | Jan 6, 2011 | Novartis Pharmaceuticals | not stated | Not stated |
| NCT01270906 | Safety of CHIR-258 (TKI258) in Advanced Solid Tumors | Phase 1 | terminated | Jan 5, 2011 | Novartis Pharmaceuticals | not stated | Not stated |
| NCT00486265 | Phase I/II, Open-label, Multi-center, Two Part Dose-escalation, Safety, Pharmacokinetics… | Phase 1 | terminated | Jun 14, 2007 | AstraZeneca | AML assess. of response in Part B patients find treatment failure in all 8 evaluable for marrow… | Other (stated, no rule matched) |
| NCT00721981 | An Evaluation of the Clinical Treatment and Patient Values and Preferences of Patients… | — | terminated | Jul 25, 2008 | AstraZeneca | Low Recruitment | Enrollment / accrual |
| NCT00733031 | Phase I, Open-label, Dose-escalation, Safety and PK Study of AZD6918 | Phase 1 | terminated | Aug 12, 2008 | AstraZeneca | PK results demonstrate low and variable plasma concentrations so that achieving therapeutic… | Other (stated, no rule matched) |
| NCT00888082 | Protection of Ovarian Function With Goserelin Acetate in Premenopausal Early Breast…(PROOF) | Phase 3 | withdrawn | Apr 24, 2009 | AstraZeneca | not stated | Not stated |
| NCT01116154 | Vorinostat and Lenalidomide in Treating Patients With Relapsed or Refractory Hodgkin… | Phase 1 | terminated | May 4, 2010 | City of Hope Medical Center | Sponsor withdrew support for the study | Other (stated, no rule matched) |
| NCT00386321 | Yt90 Zevalin and Combination Chemotherapy (Z-CHOP)in Treating Patients With Stage II,… | Phase 2 | terminated | Oct 11, 2006 | Chulalongkorn University | Participants are no longer being examined or treated. | Other (stated, no rule matched) |
| NCT00162500 | A Novel Vaccine for the Treatment of MUC1-expressing Tumor Malignancies | Phase 2 | withdrawn | Sep 13, 2005 | Hadassah Medical Organization | not stated | Not stated |
| NCT00136591 | A Phase 2 Study of Velcade™ in Subjects With Relapsed or Refractory Follicular B-Cell… | Phase 2 | terminated | Aug 29, 2005 | Lymphoma Study Association | An arm closed due to lack of efficacy | Efficacy / futility |
| NCT00927446 | Endoscopy Screening for Esophageal Cancer | — | terminated | Jun 25, 2009 | Lotung Poh-Ai Hospital | not stated | Not stated |
| NCT00103103 | Bortezomib, Fluorouracil, and Leucovorin in Treating Patients With Metastatic or… | Phase 2 | terminated | Feb 8, 2005 | California Cancer Consortium | not stated | Not stated |
| NCT00631059 | Assessment and Determination of Chemotherapy Resistance in Newly-Diagnosed or First… | N/A | terminated | Mar 7, 2008 | University of California, Irvine | Haluted due to slow accrual | Enrollment / accrual |
| NCT00428597 | A Study Of Sunitinib Compared To Placebo For Patients With Advanced Pancreatic Islet Cell… | Phase 3 | terminated | Jan 30, 2007 | Pfizer | Refer to Detailed Description. | Other (stated, no rule matched) |
| NCT00775957 | Assessment of Hematopoietic Recovery Following Chemotherapy for Non-Hodgkin's Lymphoma | — | terminated | Oct 20, 2008 | University of Oklahoma | Terminated by institutional review board | Other (stated, no rule matched) |
| NCT00952666 | Transrectal Ultrasound Imaging of the Prostate Gland and Neurovascular Bundles During… | Early Phase 1 | terminated | Aug 6, 2009 | Johns Hopkins University | The number of participants needed for this study has been met. | Other (stated, no rule matched) |
| NCT00630799 | Efficacy and Safety Study of a New Leuprolide Acetate 17 mg Depot to Treat Prostate… | Phase 3 | terminated | Mar 7, 2008 | GP-Pharm | not stated | Not stated |
| NCT00355758 | UCI 03-72 Prostate Cancer Detection by Serum Proteomic Profiling | — | terminated | Jul 25, 2006 | University of California, Irvine | Lack of personnel | Other (stated, no rule matched) |
| NCT00102024 | Safety and Activity of 90Y-Labeled IDEC-159 in Subjects With Metastatic Colorectal… | Phase 1 / Phase 2 | terminated | Jan 20, 2005 | Biogen | not stated | Not stated |
| NCT00329472 | Efficacy Study of Induction Chemotherapy Before Surgery in Operable Non-small Cell Lung… | Phase 3 | withdrawn | May 24, 2006 | Samsung Medical Center | poor enrollment | Enrollment / accrual |
| NCT01124500 | Transdermal Methylphenidate for Cancer-Related Fatigue | N/A | withdrawn | May 17, 2010 | Memorial Sloan Kettering Cancer Center | not stated | Not stated |
| NCT00014651 | Vapreotide in Treating Patients Undergoing Elective Pancreatic Resection | Phase 3 | terminated | May 5, 2004 | Mayo Clinic | Teminated by the DSMB because there are no differences between the control group and the Vapreotide… | Other (stated, no rule matched) |
| NCT00735332 | Efficacy Study of TLN-232 in Patients With Recurring Metastatic Melanoma | Phase 2 | terminated | Aug 14, 2008 | Thallion Pharmaceuticals | License termination. | Other (stated, no rule matched) |
| NCT00791544 | Dose Finding Study of AVE1642 in Patients With Advanced or Metastatic Liver Carcinoma | Phase 1 / Phase 2 | terminated | Nov 14, 2008 | Sanofi | Company decision to discontinue the AVE1642 development program, not due to any safety or efficacy… | Safety / toxicity |
| NCT00210366 | Salvage Therapy With Idarubicin in Relapsing CNS Lymphoma | Phase 2 | terminated | Sep 21, 2005 | International Extranodal Lymphoma Study Group (IELSG) | due to slow accrual | Enrollment / accrual |
| NCT00460837 | Comparison of Bowel Preparation in Virtual Colonoscopy (VC) - Patient Experience | Phase 4 | withdrawn | Apr 17, 2007 | London North West Healthcare NHS Trust | Supply of adequate label was not provided to the MHRA | Drug supply |
| NCT00647140 | Clinical Evaluation of 18F-DOPA Positron Emission Tomography in Medullary Thyroid Cancer(DOPMET) | Phase 2 | terminated | Mar 31, 2008 | Assistance Publique - Hôpitaux de Paris | Insuffisent recruitment | Enrollment / accrual |
| NCT00177853 | Celecoxib, Irinotecan and Concurrent Radiotherapy in Preoperative Pancreatic Cancer | Phase 1 | terminated | Sep 15, 2005 | University of Pittsburgh | terminated | Other (stated, no rule matched) |
| NCT00279773 | Safety, Pharmacokinetics and Pharmacodynamics of TKI258 in Subjects With Acute Myeloid… | Phase 1 | terminated | Jan 20, 2006 | Novartis Pharmaceuticals | Study was stopped due to time dependent drug accumulation | Other (stated, no rule matched) |
| NCT01010321 | Confocal Microscopy of Benign and Malignant Skin Tumors | — | suspended | Nov 10, 2009 | Sheba Medical Center | not stated | Not stated |
| NCT00783471 | Docetaxel Intermittent-Erlotinib (Tarceva®) In Metastatic Non Small Cell Lung Cancer…(DOPERLO) | Phase 2 | terminated | Oct 31, 2008 | Hellenic Cooperative Oncology Group | The low accrual rate of the study (30% of the expected accrual rate)/Low efficacy in both treatment… | Efficacy / futility |
| NCT00515970 | Curettage Versus Excision in Nodular and Superficial Basal Cell Carcinomas | N/A | suspended | Aug 14, 2007 | University Hospital Tuebingen | Problems with the electronic data collection program | Other (stated, no rule matched) |
| NCT00003567 | Gene Therapy and Chemotherapy in Treating Patients With Advanced Solid Tumors or… | Phase 1 | terminated | Jan 27, 2003 | Case Comprehensive Cancer Center | slow accrual | Enrollment / accrual |
| NCT00005997 | Rebeccamycin Analogue in Treating Patients With Advanced Liver and/or Biliary Cancer | Phase 2 | terminated | Jan 27, 2003 | Case Comprehensive Cancer Center | slow accrual for Cohort II | Enrollment / accrual |
| NCT00077103 | Induction Chemotherapy Using Doxorubicin and Cisplatin Followed by Combretastatin A4… | Phase 1 / Phase 2 | terminated | Feb 11, 2004 | Case Comprehensive Cancer Center | slow accrual | Enrollment / accrual |
| NCT00110006 | Positron Emission Tomography Using Fludeoxyglucose F 18 in Predicting Response to… | N/A | withdrawn | May 4, 2005 | Case Comprehensive Cancer Center | No accrual | Enrollment / accrual |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Feb 2, 2011source: clinicaltrials