Clinical trial · Interventional
Positron Emission Tomography Using Fludeoxyglucose F 18 in Predicting Response to Treatment in Patients Who Are Receiving Rituximab and Combination Chemotherapy for Newly Diagnosed Non-Hodgkin's Lymphoma
Prognostic Significance of Early Positron Emission Tomography (PET) With Fluorine-18 Fluorodeoxyglucose ([18F] FDG) in Intermediate and High Grade Non-Hodgkin's Lymphoma
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): No accrual
Summary
Brief summary (as posted)
RATIONALE: Diagnostic procedures, such as positron emission tomography (PET) using fludeoxyglucose F 18, may help in learning how well chemotherapy works to kill cancer cells and allow doctors to plan better treatment. Comparing results of diagnostic procedures done before, during, and after chemotherapy may help doctors predict a patient's response to treatment and help plan the best treatment. PURPOSE: This clinical trial is studying positron emission tomography using fludeoxyglucose F 18 to see how well it works in predicting response to treatment in patients who are receiving rituximab and combination chemotherapy for newly diagnosed non-Hodgkin's lymphoma.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Lymphoma | Lymphoma | ONTOLOGY_EXACT | 0.90 |
Interventions
Interventions (7)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| cyclophosphamide | Drug | Cyclophosphamide | ALIAS |
| doxorubicin hydrochloride | Drug | Doxorubicin | ALIAS |
| fludeoxyglucose F 18 | Radiation | — | UNRESOLVED |
| positron emission tomography | Procedure | — | UNRESOLVED |
| prednisone | Drug | Prednisone | ALIAS |
| rituximab | Biological | Rituximab | ALIAS |
| vincristine sulfate | Drug | Vincristine | ALIAS |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (3)
- measure
- Complete remission as measured by positron emission tomography (PET) at 7-10 days after R-CHOP, and after completion of study treatment
- timeFrame
- at 7-10 days after R-CHOP, and after completion of study treatment
- measure
- Overall survival at 7-10 days after R-CHOP, and after completion of study treatment
- timeFrame
- at 7-10 days after R-CHOP, and after completion of study treatment
- measure
- Disease-free survival at 7-10 days after R-CHOP, and after completion of study treatment
- timeFrame
- at 7-10 days after R-CHOP, and after completion of study treatment
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
DISEASE CHARACTERISTICS:
* Histologically confirmed newly diagnosed non-Hodgkin's lymphoma (NHL)
* Intermediate- or high-grade disease
* Stage I-IV disease
* Any of the following subtypes are allowed:
* Diffuse large B-cell lymphoma
* Anaplastic large cell lymphoma
* Mantle cell lymphoma
* Grade 3 follicular lymphoma
* Mediastinal B-cell lymphoma
* The following subtypes are not allowed:
* Lymphoblastic lymphoma
* Mycosis fungoides/Sézary's syndrome
* HTLV-1 associated T-cell leukemia or lymphoma
* Primary CNS lymphoma
* HIV-associated lymphoma
* Transformed lymphoma
* Burkitt's lymphoma
* Adequate staging of lymphoma by any of the following methods:
* CT scan or MRI of affected sites
* Unilateral or bilateral bone marrow biopsy
* Positive pre-treatment positron emission tomography (PET) scan
* Lumbar puncture
* Radiographically measurable disease by PET scan
* Any International Prognostic Index risk category allowed
* No prior diagnosis of another hematologic malignancy NOTE: A new classification scheme for adult non-Hodgkin's lymphoma has been adopted by PDQ. The terminology of "indolent" or "aggressive" lymphoma will replace the former terminology of "low", "intermediate", or "high" grade lymphoma. However, this protocol uses the former terminology.
PATIENT CHARACTERISTICS:
Age
* 18 and over
Performance status
* Not specified
Life expectancy
* Not specified
Hematopoietic
* Absolute neutrophil count \> 1,000/mm\^3\*
* Platelet count ≥ 75,000/mm\^3\* NOTE: \*Unless due to NHL
Hepatic
* Bilirubin ≤ 2.0 mg/dL\* (excluding Gilbert's disease) NOTE: \*Unless due to NHL
Renal
* Creatinine ≤ 2.0 mg/dL (unless due to NHL)
Cardiovascular
* Ejection fraction ≥ 45% by echocardiogram or MUGA
Other
* Not pregnant or nursing
* Negative pregnancy test
* Fertile patients must use effective contraception
* HIV negative
* No other malignancy within the past 5 years except superficial nonmelanoma skin cancer or carcinoma in situ of the cervix
* No other serious co-morbid disease that would preclude study participation
PRIOR CONCURRENT THERAPY:
Biologic therapy
* No prior rituximab for NHL
* No concurrent filgrastim \[G-CSF\] during course 1 of study treatment except for patients \> 70 years of age OR patients with active infection
Chemotherapy
* No prior chemotherapy for NHL
Endocrine therapy
* No prior steroids for NHL
Radiotherapy
* No prior radiotherapy for NHL
* Concurrent consolidation radiotherapy to sites of bulky disease allowed at the discretion of the attending physician
Surgery
* Not specified
Other
* No other prior treatment for NHLReferences
Publications (0)
Data not yet available