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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
12,388 stopped studies mapped to Malignant Neoplasm and descendants · 89% state a reason
Over the 12,388 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT00989105 | Technetium Tc 99m Demobesin-4 for Imaging Procedures in Patients With Prostate Cancer | Phase 1 | terminated | Oct 2, 2009 | Cancer Research UK | not stated | Not stated |
| NCT01132599 | Comparing PET-CT Using C-11 Choline and 18F-Fluoromethylcholine in Patients With… | Phase 2 | withdrawn | May 28, 2010 | Cancer Research UK | not stated | Not stated |
| NCT01212887 | Treated Blood Cells, Cyclophosphamide, Fludarabine Phosphate, and Aldesleukin in Treating… | Phase 1 | terminated | Oct 1, 2010 | Cancer Research UK | due to safety concerns and lack of efficacy | Safety / toxicity |
| NCT00151671 | Effect of a Perioperative Oral Nutritional Supplementation on Patients Undergoing Hepatic…(IMPACT) | Phase 2 / Phase 3 | terminated | Sep 9, 2005 | Rennes University Hospital | insufficient enrollment rate | Enrollment / accrual |
| NCT01096381 | Potential Biomarkers for Bevacizumab-Induced High Blood Pressure in Patients With Solid… | — | terminated | Mar 31, 2010 | Vanderbilt-Ingram Cancer Center | funding withdrawn due to fellow's departure from VICC | Funding |
| NCT00378781 | Heparin or M-EDTA in Preventing Catheter-Related Infections and Blockages in Patients at… | N/A | withdrawn | Sep 21, 2006 | M.D. Anderson Cancer Center | Study withdrawn. | Other (stated, no rule matched) |
| NCT00488553 | Molecular Epidemiology of Lymphoma Patients | — | withdrawn | Jun 20, 2007 | M.D. Anderson Cancer Center | No participants recruited, study discontinued. | Enrollment / accrual |
| NCT00653367 | Evaluation of Chronic Pain After Nerve Section During Thoracotomy | N/A | withdrawn | Apr 4, 2008 | Rigshospitalet, Denmark | not stated | Not stated |
| NCT00585741 | Pilot Study of 18F-FLT PET | N/A | terminated | Jan 3, 2008 | University of Wisconsin, Madison | not stated | Not stated |
| NCT01452334 | Safety Study of Anti-Programmed Death-Ligand 1 in Hematologic Malignancy | Phase 1 | withdrawn | Oct 14, 2011 | Bristol-Myers Squibb | not stated | Not stated |
| NCT00003599 | Vitamin E in Preventing the Side Effects of Isotretinoin in Former and Current Smokers… | Phase 3 | withdrawn | Sep 13, 2004 | M.D. Anderson Cancer Center | Withdrawn study. | Other (stated, no rule matched) |
| NCT00003714 | Chemotherapy in Treating Patients With Unresectable Primary or Metastatic Kidney Cancer | Phase 2 | withdrawn | Sep 14, 2004 | M.D. Anderson Cancer Center | Withdrawn | Other (stated, no rule matched) |
| NCT00074750 | Study of DT388GMCSF Fusion Protein in Acute Myelogenous Leukemia (AML) and Chronic… | Phase 1 | terminated | Dec 23, 2003 | M.D. Anderson Cancer Center | Slow accrual. | Enrollment / accrual |
| NCT00502814 | 3-Dimensional Form and Soft Tissue Biomechanics of the Breast | — | terminated | Jul 18, 2007 | M.D. Anderson Cancer Center | Sample size too small for data analysis. | Other (stated, no rule matched) |
| NCT01003626 | Interstitial Fluid Pressure (IFP) Pilot Study in Melanoma Patients | N/A | withdrawn | Oct 29, 2009 | M.D. Anderson Cancer Center | Slow accrual. | Enrollment / accrual |
| NCT00005969 | Liposomal Tretinoin in Treating Patients With Recurrent or Refractory Hodgkin's Disease | Phase 2 | withdrawn | Apr 28, 2004 | M.D. Anderson Cancer Center | Study withdrawn. | Other (stated, no rule matched) |
| NCT01189513 | SCH-900105 in Recurrent Glioblastoma | Phase 1 | withdrawn | Aug 26, 2010 | M.D. Anderson Cancer Center | Sponsor decision. | Sponsor / business decision |
| NCT01318200 | Transarterial Chemoembolization (TACE) vs. CyberKnife for Recurrent Hepatocellular… | Phase 3 | withdrawn | Mar 18, 2011 | Accuray Incorporated | not stated | Not stated |
| NCT00696007 | Neoadjuvant Chemotherapy Plus Nephroureterectomy for Locally Advanced Upper Tract… | Phase 2 | withdrawn | Jun 12, 2008 | Lahey Clinic | Study was unable to recruit subjects meeting the study requirements. | Enrollment / accrual |
| NCT00430014 | Study of Atiprimod Treatment for Patients With Advanced Cancer | Phase 1 | terminated | Feb 1, 2007 | M.D. Anderson Cancer Center | Sponsor Withdrew | Other (stated, no rule matched) |
| NCT00475332 | Study to Treat Relapsed Follicular Non-Hodgkin's Lymphoma With Radiation and Bexxar | Phase 2 | terminated | May 21, 2007 | University of Florida | PI left our institution | Investigator |
| NCT01063400 | Feasibility Study: Comparison of Performance Status With Objective Physical Activity… | — | terminated | Feb 5, 2010 | University of Wisconsin, Madison | lack of funding | Funding |
| NCT00472771 | INNO-206 in Patients With Small Cell Lung Cancer (SCLC) | Phase 2 | withdrawn | May 14, 2007 | CytRx | Terminated due to clinical trial material production delays | Other (stated, no rule matched) |
| NCT00411593 | Phase I-II for Patients With Recurrent or Refractory Non-small Cell Lung Cancer (NSCLC) | Phase 1 / Phase 2 | withdrawn | Dec 14, 2006 | M.D. Anderson Cancer Center | Lack of Patient Accrual | Enrollment / accrual |
| NCT00736164 | Selenomethionine in Treating Patients Undergoing Surgery or Internal Radiation Therapy… | Phase 2 | withdrawn | Aug 15, 2008 | Roswell Park Cancer Institute | No accrual | Enrollment / accrual |
| NCT00124748 | Efficacy of 400 Mg Versus 800 Mg Imatinib in Chronic Myeloid Leukemia in Chronic Phase…(TOPS) | Phase 3 | terminated | Jul 28, 2005 | Novartis Pharmaceuticals | This study was prematurely discontinued because no improvement was observed in the 800mg dose… | Other (stated, no rule matched) |
| NCT00609310 | Dietary Bioflavonoid Supplementation for the Prevention of Neoplasia Recurrence | Phase 2 | suspended | Feb 7, 2008 | Technische Universität Dresden | not stated | Not stated |
| NCT00768001 | Genetic Analysis of Liver Cancer | — | terminated | Oct 7, 2008 | Samuel So | low accrual | Enrollment / accrual |
| NCT00967291 | Mitomycin C and Ifosfamide in Treating Patients With Metastatic Pancreatic Cancer(PACT-11) | Phase 2 | terminated | Aug 27, 2009 | IRCCS San Raffaele | lack of activity and G3-4 toxicity at interim analysis | Safety / toxicity |
| NCT00969033 | CS-1008 Used With Irinotecan Versus Irinotecan Alone in Subjects With Metastatic… | Phase 2 | terminated | Aug 31, 2009 | Daiichi Sankyo | not stated | Not stated |
| NCT01132404 | Study in Men With Prostate Cancer to Assess the Safety, Pharmacokinetics and… | Phase 1 / Phase 2 | terminated | May 28, 2010 | Millennium Pharmaceuticals, Inc. | Developing new formulation of study drug. New study to open next year under a new protocol. | Other (stated, no rule matched) |
| NCT01409187 | IPI-Biotherapy for Patients Previously Treated With Cytotoxic Drugs With Metastatic… | Phase 1 / Phase 2 | withdrawn | Aug 4, 2011 | M.D. Anderson Cancer Center | not stated | Not stated |
| NCT01254136 | Safety and Efficacy of INCB007839 With Trastuzumab and Vinorelbine in Patients With… | Phase 1 / Phase 2 | terminated | Dec 6, 2010 | Incyte Corporation | Incyte has suspended development of the compound. | Other (stated, no rule matched) |
| NCT01456182 | Phase 1B- Open Label Dose-Ranging Study of Oral AFX-2 in Adults With Chronic Lymphocytic… | Phase 1 | withdrawn | Oct 20, 2011 | Afexa Life Sciences Inc | not stated | Not stated |
| NCT00419081 | Study of Forodesine Hydrochloride in Patients With Relapsed/Refractory Precursor… | Phase 2 | terminated | Jan 8, 2007 | BioCryst Pharmaceuticals | Issues with Manufacturing | Drug supply |
| NCT00351637 | Sublingual Methadone for the Management of Cancer-related Procedure Pain in Inpatients | Phase 2 | terminated | Jul 13, 2006 | Alberta Health services | Study suspended due to low accrual | Enrollment / accrual |
| NCT00363441 | A Study of Conventional 3D Radiation vs. Intensity-Modulated Radiation in Squamous Cell… | Phase 2 / Phase 3 | withdrawn | Aug 15, 2006 | Alberta Health services | not stated | Not stated |
| NCT00446303 | A Phase II Study of Maintenance With Azacitidine in MDS Patients | Phase 2 | terminated | Mar 12, 2007 | Groupe Francophone des Myelodysplasies | not stated | Not stated |
| NCT00296062 | Dose Dense Therapy and Bevacizumab in Solid Tumors and Colorectal Cancer | Phase 1 | terminated | Feb 24, 2006 | Case Comprehensive Cancer Center | Trial did not move to Phase II portion due to poor tolerance of treatment | Other (stated, no rule matched) |
| NCT00508456 | Dietary Methionine Restriction Plus Temozolomide for Recurrent GBM | Phase 1 | terminated | Jul 30, 2007 | M.D. Anderson Cancer Center | Low Accrual | Enrollment / accrual |
| NCT01142414 | Chemotherapy and Radiation Therapy With or Without Panitumumab in Treating Patients Who… | Phase 3 | withdrawn | Jun 11, 2010 | European Organisation for Research and Treatment of Cancer - EORTC | not stated | Not stated |
| NCT01510288 | Phase 1 Trial of Ipilimumab and GVAX in Patients With Metastatic Castration-resistant… | Phase 1 | terminated | Jan 16, 2012 | Amsterdam UMC, location VUmc | The study was terminated because Cell Genesys stopped all activities for GVAX. | Other (stated, no rule matched) |
| NCT00245128 | Imatinib Mesylate in Treating Patients With Myelofibrosis | Phase 2 | terminated | Oct 27, 2005 | OHSU Knight Cancer Institute | Per PI, results from another similar study were published prior to study analysis. Negative study… | Other (stated, no rule matched) |
| NCT01175278 | Vertebral Augmentation With Kyphoplasty vs Nonsurgical Mgmt for Vertebral Body… | N/A | withdrawn | Aug 4, 2010 | H. Lee Moffitt Cancer Center and Research Institute | No enrollment | Enrollment / accrual |
| NCT00492388 | Safety and Efficacy of PMI-150 (Intranasal Ketamine) for the Treatment of Breakthrough… | Phase 3 | terminated | Jun 27, 2007 | Hospira, now a wholly owned subsidiary of Pfizer | Business decision not to continue development | Sponsor / business decision |
| NCT00758693 | Frontline Treatment With Bendamustine in Combination With Rituximab in Adults Age 65 or… | Phase 2 | withdrawn | Sep 25, 2008 | University of Kentucky | Funding was withdrawn due to insufficient accrual | Enrollment / accrual |
| NCT01105988 | Evaluating Tumor Pseudoprogression With FLT-PET and MRI | Early Phase 1 | terminated | Apr 19, 2010 | Massachusetts General Hospital | Funding ended | Funding |
| NCT00585819 | Validation of a Novel Thoracic Neoplasm Radiotherapy Image Guidance Technique: A Pilot… | N/A | withdrawn | Jan 3, 2008 | University of Wisconsin, Madison | lack of interest | Other (stated, no rule matched) |
| NCT01169870 | Genexol-PM Versus Paclitaxel in Anthracycline-pretreated Metastatic Breast Cancer Patients | Phase 2 | withdrawn | Jul 26, 2010 | National Cancer Center, Korea | withdrawn studies | Other (stated, no rule matched) |
| NCT00504491 | R-CHOP and Alemtuzumab in Patients With Chronic Lymphocytic Leukemia(R-CHOP) | Phase 2 | withdrawn | Jul 20, 2007 | CABYC | IMP new owner decision | Other (stated, no rule matched) |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Feb 28, 2012source: clinicaltrials