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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
848 stopped studies mapped to Malignant Large Intestinal Neoplasm and descendants · 91% state a reason
Over the 848 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT03161574 | FOLFOXIRI Chemotherapy Alone as Neoadjuvant Treatment for Circumferential Radial Margin… | Phase 2 | withdrawn | May 22, 2017 | Guangxi Medical University | No participants were recruited | Enrollment / accrual |
| NCT03677960 | Study of Topical ABI-1968 in Subjects With Precancerous Anal Lesions Resulting From Human… | Phase 1 | terminated | Sep 19, 2018 | Antiva Biosciences | Pre-Clinical Toxicology Findings | Other (stated, no rule matched) |
| NCT00126867 | Thymidylate Synthase Polymorphisms as a Predictor of Toxicity to Capecitabine… | — | terminated | Aug 5, 2005 | AHS Cancer Control Alberta | Insufficient accrual and no funding | Enrollment / accrual |
| NCT02422680 | Patient Satisfaction With Colonoscopy in a Danish Setting - What Are the Most Important… | — | withdrawn | Apr 21, 2015 | Aalborg University Hospital | Cancelled according to PhD-protocol with insufficient time to complete the study | Other (stated, no rule matched) |
| NCT02585271 | Transanal Decompression Tube Versus Stent for Acute Malignant Left-sided Colonic and… | N/A | terminated | Oct 23, 2015 | Xuzhou Central Hospital | We can not get enough sample size. | Other (stated, no rule matched) |
| NCT02005614 | A Pilot/Phase II Study of Gamma Knife Radiosurgery for Brain Metastases Using 3Tesla MRI… | N/A | terminated | Dec 9, 2013 | Yale University | Unable to recruit patients. | Enrollment / accrual |
| NCT03431311 | T Cell Receptor Based Therapy of Metastatic Colorectal Cancer(TCR-CRC-001) | Phase 1 / Phase 2 | terminated | Feb 13, 2018 | Oslo University Hospital | Sponsor decision | Sponsor / business decision |
| NCT00777192 | Longitudinal Study of Symptoms in Colorectal Cancer | — | terminated | Oct 22, 2008 | M.D. Anderson Cancer Center | Terminated at continuing review | Other (stated, no rule matched) |
| NCT03532204 | Oligometastases of the LIVer Treated With Chemotherapy With ou Without Extracranial…(OLIVER) | N/A | withdrawn | May 22, 2018 | UNICANCER | no participants enrolled | Enrollment / accrual |
| NCT03634202 | Study of Radiation Therapy in Combination With Xeloda, for Initially Metastatic, Low and…(DESIR) | N/A | terminated | Aug 16, 2018 | Institut Cancerologie de l'Ouest | the study was stopped for lack of inclusion | Other (stated, no rule matched) |
| NCT03645876 | SHR-1210 in Combination With BP102 and XELOX in Patient With Metastatic Colorectal Cancer | Phase 2 | terminated | Aug 24, 2018 | Jiangsu HengRui Medicine Co., Ltd. | The study was terminated early due to company decision | Sponsor / business decision |
| NCT03070574 | Mesalamine for Colorectal Cancer Prevention Program in Lynch Syndrome(MesaCAPP) | Phase 2 | terminated | Mar 3, 2017 | Christoph Gasche | Due to poor patient recruitment and insufficient financing. | Enrollment / accrual |
| NCT01479465 | Efficacy and Safety of Simtuzumab (SIM) With FOLFIRI as Second Line Treatment in… | Phase 2 | terminated | Nov 24, 2011 | Gilead Sciences | not stated | Not stated |
| NCT01879943 | Capsule Versus Conventional Colonoscopy in Patient Following Colorectal Surgery | N/A | terminated | Jun 18, 2013 | IHU Strasbourg | Operational difficulties related to medical staff turnover (investigators departure and sickness… | Other (stated, no rule matched) |
| NCT00423345 | Colon Investigation - Factors Determining Choice of Procedure | — | terminated | Jan 18, 2007 | Sykehuset Telemark | One of the examinations (double contrast baium enema) became outdated in Norway | Other (stated, no rule matched) |
| NCT00835055 | Expression of Molecular Markers Before and After Neo-adjuvant Chemoradiotherapy in Rectal… | — | withdrawn | Feb 3, 2009 | St. Claraspital AG | never started several reasons | Other (stated, no rule matched) |
| NCT02139475 | Factors Influencing Quality of Bowel Cleansing for Colonoscopy in Patients With… | — | terminated | May 15, 2014 | Yonsei University | All the patients who had been targeted were registered. | Other (stated, no rule matched) |
| NCT02568046 | Sym004 in Combination With FOLFIRI in Metastatic Colorectal Cancer Patients | Phase 1 / Phase 2 | terminated | Oct 5, 2015 | Symphogen A/S | Discontinued development of Sym004 in combination with FOLFIRI | Other (stated, no rule matched) |
| NCT03455751 | Precision Pain Management for Major Abdominal Surgery in Colorectal Surgery(PPaM) | N/A | terminated | Mar 7, 2018 | The Cleveland Clinic | Failed to meet enrollment goals | Enrollment / accrual |
| NCT00264979 | Evaluation of 2 Resection Strategies of Synchronous Colorectal Cancer Metastases(METASYNC) | N/A | terminated | Dec 13, 2005 | Rennes University Hospital | Stop recommended following the last sequential analysis | Other (stated, no rule matched) |
| NCT01445054 | 111 Indium CHX-A DTPA Trastuzumab (Indium-Herceptin) for Imaging Breast Cancer | Early Phase 1 | terminated | Oct 3, 2011 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT02883790 | Effects of Somnage® in the Management on Sleep and Mood in Cancer Patients | N/A | terminated | Aug 30, 2016 | Helsinn Healthcare SA | Low enrolment rate | Enrollment / accrual |
| NCT02605044 | Masitinib in Combination With FOLFIRI for Second-line Treatment of Patients With… | Phase 3 | terminated | Nov 16, 2015 | AB Science | Sponsor decision based on portfolio prioritization | Sponsor / business decision |
| NCT01871311 | A Phase I Study of Nilontinib and Cetuximab in Patients With Solid Tumors | Phase 1 | terminated | Jun 6, 2013 | Georgetown University | Primary investigator left the institution. | Investigator |
| NCT01458925 | Feasibility of Check-Cap's P1 Capsule System Screening | N/A | terminated | Oct 25, 2011 | Check-Cap Ltd. | All trials ojectives were met | Other (stated, no rule matched) |
| NCT03717038 | Sym004 Versus TAS-102 in Patients With mCRC | Phase 3 | withdrawn | Oct 23, 2018 | Symphogen A/S | Study was withdrawn due to administrative reasons | Other (stated, no rule matched) |
| NCT02402036 | A Biomarker Study in Patients Getting Regorafenib for Metastatic Colorectal Cancer | Phase 2 | terminated | Mar 30, 2015 | Georgetown University | not stated | Not stated |
| NCT02205398 | Study of Safety and Efficacy of INC280 and Cetuximab, in Adult c-MET Positive mCRC and… | Phase 1 | terminated | Jul 31, 2014 | Novartis Pharmaceuticals | not stated | Not stated |
| NCT02726334 | A Phase I, Dose Escalation Study of BNC101 in Patients With Metastatic Colorectal Cancer. | Phase 1 | terminated | Apr 1, 2016 | Bionomics Limited | Monotherapy arm completed. Combination arm did not proceed (sponsor decision). | Sponsor / business decision |
| NCT00651677 | Hand Assisted Versus "Pure" Laparoscopic Assisted Proctectomy for Rectal Cancer | N/A | withdrawn | Apr 3, 2008 | Weill Medical College of Cornell University | funding issues | Funding |
| NCT00611858 | Cetuximab, 5-FU and Radiation as Neoadjuvant Therapy for Patients With Locally Advanced… | Phase 2 | terminated | Feb 11, 2008 | Dana-Farber Cancer Institute | Slow accrual | Enrollment / accrual |
| NCT01925274 | A Study Of PF-05212384 Plus Irinotecan Vs Cetuximab Plus Irinotecan In Patients With KRAS… | Phase 2 | terminated | Aug 19, 2013 | Pfizer | Enrollment to the study was terminated on 11Nvo2014 due to slow recruitment. There were no safety… | Safety / toxicity |
| NCT01523639 | A Randomized, Placebo-controlled, Double-blind Phase II Study Evaluating if Glucophage…(G-LUCAS) | Phase 2 | terminated | Feb 1, 2012 | Austrian Breast & Colorectal Cancer Study Group | Prematurely due to slow recruitment (07/08/2013). Newly defined study end=LPLV=05/11/2013. ABCSG… | Enrollment / accrual |
| NCT00267787 | Molecular Genetic and Pathological Studies of Anal Tumors | — | terminated | Dec 21, 2005 | Stanford University | not stated | Not stated |
| NCT01313026 | Treatment of "Low Anterior Resection Syndrome" by Percutaneous Nerve Evaluation and… | N/A | terminated | Mar 11, 2011 | University of Aarhus | Difficult to recruit participants | Enrollment / accrual |
| NCT00005030 | SCH 66336 Before Surgery in Treating Patients With Colorectal Cancer That Has… | Phase 1 | withdrawn | Jun 4, 2004 | M.D. Anderson Cancer Center | No enrollment. | Enrollment / accrual |
| NCT01740947 | Does Administration of Antibiotics in Patients Undergoing Surgery for Colorectal Cancer…(SELECT) | Phase 4 | terminated | Dec 4, 2012 | H. Jaap Bonjer, PhD | Superiority was no longer attainable | Other (stated, no rule matched) |
| NCT02669914 | MEDI4736 (Durvalumab) in Patients With Brain Metastasis From Epithelial-derived Tumors | Phase 2 | terminated | Feb 1, 2016 | Washington University School of Medicine | Low accrual, funding withdrawn by AstraZeneca, and change in clinical practice | Enrollment / accrual |
| NCT03527784 | Prestoma-Trial for Parastomal Hernia Prevention | N/A | terminated | May 17, 2018 | University of Oulu | Parastomal Parietex withdrawn from market by the manufacturer. | Drug supply |
| NCT03493009 | Optimizing the Preparation Regime Prior to Colonoscopy Procedure With Pure-Vu System | N/A | withdrawn | Apr 10, 2018 | Motus GI Medical Technologies Ltd | Difficulties to sign a contract with the hospital, due to logistic changes in the hospital. | Other (stated, no rule matched) |
| NCT00254436 | A Double-Blind, Randomized, Placebo-Controlled Study of the Efficacy and Safety of Weekly… | Phase 3 | terminated | Nov 16, 2005 | M.D. Anderson Cancer Center | not stated | Not stated |
| NCT03340558 | Atezolizumab Monotherapy vs Atezolizumab Plus Cobimetinib in Liver Metastases From…(ATELIER) | Phase 2 | withdrawn | Nov 13, 2017 | Niharika Mettu | Negative results in a similar study | Other (stated, no rule matched) |
| NCT03014284 | Novel Listeria Vectors Secreting Gut Flora-Altering Agents to Prevent Colon Cancer and… | — | withdrawn | Jan 9, 2017 | The University of Texas Health Science Center at San Antonio | Military collaborator sample supplier was transferred, no samples obtained | Other (stated, no rule matched) |
| NCT03232814 | Walk on: A Community-based Approach to Increase Physical Activity Among Men Treated for… | N/A | withdrawn | Jul 28, 2017 | University of Ottawa | No participants were recruited due to a lack of referrals. | Enrollment / accrual |
| NCT02650635 | TLR8 Agonist VTX-2337 and Cyclophosphamide in Treating Patients With Metastatic,… | Phase 1 | terminated | Jan 8, 2016 | Mayo Clinic | permanently closed per sponsor's request | Other (stated, no rule matched) |
| NCT03096899 | A Study to Estimate Overall Survival in Patients Receiving Best Supportive Care for… | — | withdrawn | Mar 30, 2017 | The Rogosin Institute | The investigator conducting the study determined that the entry criteria for the proposed subjects… | Investigator |
| NCT02216149 | Effects of S-1 and Capecitabine on Coronary Artery Blood Flow(FluoHeart) | Phase 2 | terminated | Aug 13, 2014 | Heikki Joensuu | Slow accrual | Enrollment / accrual |
| NCT03182894 | Epacadostat in Combination With Pembrolizumab and Azacitidine in Subjects With Metastatic… | Phase 1 / Phase 2 | withdrawn | Jun 9, 2017 | James J Lee | Study will not be conducted due to changes related to the investigational agent. | Other (stated, no rule matched) |
| NCT01286883 | Cancer Stem Cell Markers and Prognostic Markers in Circulating Tumor Cells | — | terminated | Jan 31, 2011 | Milton S. Hershey Medical Center | PI left Institution | Investigator |
| NCT02508077 | FOLFIRI and Panitumumab in Treating Patients With RAS and BRAF Wild-Type Metastatic… | Phase 2 | terminated | Jul 24, 2015 | City of Hope Medical Center | Poor Accrual | Enrollment / accrual |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Aug 8, 2019source: clinicaltrials