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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
881 stopped studies mapped to Malignant Intestinal Neoplasm and descendants · 90% state a reason
Over the 881 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT02228785 | A Study of the Safety and Tolerance of Three Doses of G17DT in Metastatic Colorectal…(CC1C) | Phase 2 | terminated | Aug 29, 2014 | Cancer Advances Inc. | Poor local tolerance to injection. | Other (stated, no rule matched) |
| NCT00538291 | Cetuximab and Capecitabine in Treating Patients With Metastatic Colorectal Cancer That… | Phase 2 | terminated | Oct 2, 2007 | City of Hope Medical Center | Study was terminated early due to lack of efficacy. | Efficacy / futility |
| NCT01365910 | Linifanib in Treating Patients With Advanced, Refractory Colorectal Cancer | Phase 2 | terminated | Jun 3, 2011 | Vanderbilt-Ingram Cancer Center | Interim analysis determined the study did not meet criteria to proceed | Efficacy / futility |
| NCT01574677 | Assessment of Septin9 Biomarker for Detection of Colorectal Cancer in Patients With… | — | withdrawn | Apr 10, 2012 | Epigenomics, Inc | not stated | Not stated |
| NCT00499369 | Irinotecan and Cetuximab With or Without Bevacizumab in Treating Patients With Metastatic… | Phase 3 | terminated | Jul 11, 2007 | National Cancer Institute (NCI) | Due to inadequate accrual, study was terminated and limited outcome data was reported. | Enrollment / accrual |
| NCT02204332 | Phase II-b Randomized Clinical Trial of Cabazitaxel in Metastatic Colorectal Cancer…(COMETA) | Phase 2 | terminated | Jul 30, 2014 | Hospital Clinico Universitario de Santiago | Interim analysis performed on the first 10 patients showed no efficacy of cabazitaxel | Efficacy / futility |
| NCT01198548 | High-Dose Cholecalciferol in Treating Patients Receiving Combination Chemotherapy and… | Phase 2 | terminated | Sep 10, 2010 | Roswell Park Cancer Institute | Lack of funding | Funding |
| NCT01941173 | Short-Infusion Ziv-aflibercept in Treating Patients With Metastatic Colorectal Cancer… | N/A | withdrawn | Sep 13, 2013 | City of Hope Medical Center | Lack of accrual | Enrollment / accrual |
| NCT01418742 | SKIP - A Double-blind Placebo-controlled Randomized Multicenter Trial of Skin Toxicity… | Phase 2 | terminated | Aug 17, 2011 | Gesellschaft fur Medizinische Innovation - Hamatologie und Onkologie mbH | Recruitement did not meet expectations. Prev. differentiation of RAS-wild-type and mutated RAS are… | Enrollment / accrual |
| NCT00107315 | Bevacizumab and Capecitabine as First-Line Therapy in Treating Older Patients With… | Phase 2 | terminated | Apr 6, 2005 | Roswell Park Cancer Institute | Terminated due to low accrual | Enrollment / accrual |
| NCT00089076 | MDX-010 in Treating Patients With Recurrent or Refractory Lymphoma | Phase 1 / Phase 2 | terminated | Aug 5, 2004 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00835679 | Cetuximab and/or Dasatinib in Patients With Colorectal Cancer and Liver Metastases That… | Early Phase 1 | terminated | Feb 4, 2009 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00006037 | Chemotherapy Plus IM-862 in Treating Patients With Metastatic Colorectal Cancer | Phase 2 | terminated | Feb 26, 2004 | University of Southern California | Drug not available | Other (stated, no rule matched) |
| NCT00323011 | FOLFIRI + Bevacizumab With or Without Dalteparin in First Line Treatment of Advanced… | Phase 2 | terminated | May 9, 2006 | University of Southern California | drug not available | Other (stated, no rule matched) |
| NCT00933985 | Obatoclax Mesylate, Vincristine Sulfate, Doxorubicin Hydrochloride, and Dexrazoxane… | Phase 1 | terminated | Jul 8, 2009 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT01587872 | Double-balloon Colonoscopy to Increase Colonoscopy Completion Rate | N/A | terminated | Apr 30, 2012 | Sorlandet Hospital HF | Slow patient recruitment, not enough patients willing to participate within the prespecified time… | Enrollment / accrual |
| NCT01233505 | Veliparib, Oxaliplatin, and Capecitabine in Treating Patients With Advanced Solid Tumors | Phase 1 | terminated | Nov 3, 2010 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00088933 | Vaccine Therapy and Sargramostim With or Without Docetaxel in Treating Patients With… | Phase 1 | terminated | Aug 5, 2004 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT01320267 | Single Port Laparoscopic Colectomy(SILS) | Phase 1 / Phase 2 | withdrawn | Mar 22, 2011 | University of British Columbia | Industry Funding Withdrawn | Funding |
| NCT00003786 | Irofulven in Treating Patients With Metastatic or Recurrent Colorectal Cancer | Phase 2 | withdrawn | Aug 4, 2004 | University of Chicago | NO participants | Other (stated, no rule matched) |
| NCT00101205 | Oxaliplatin, Ifosfamide and Etoposide in Treating Young Patients With Recurrent or… | Phase 1 | terminated | Jan 10, 2005 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00394992 | Adjuvant Xeloda Plus Eloxatin +/- Avastin After Radical Resection of Liver Metastasis of… | Phase 3 | terminated | Nov 2, 2006 | Dutch Colorectal Cancer Group | Data from the C08 study and Avant study | Other (stated, no rule matched) |
| NCT01403103 | Cholecalciferol(25-[OH]-Vitamin D) in Treating Patients With Colorectal Cancer | Early Phase 1 | withdrawn | Jul 27, 2011 | Case Comprehensive Cancer Center | Slow Accrual | Enrollment / accrual |
| NCT00819754 | A Phase I/II Study of IXO With Bevacizumab in Patients With Metastatic Colorectal Cancer(IXO+A) | Phase 1 / Phase 2 | terminated | Jan 9, 2009 | Ottawa Hospital Research Institute | not stated | Not stated |
| NCT01344902 | An Open Dose-finding Study of Oral Applied Hexaminolevulinate (HAL) Imaging in Patients… | Phase 1 / Phase 2 | terminated | Apr 29, 2011 | Photocure | The study was stopped due to inadequate efficacy after 13 patients were evaluated. | Efficacy / futility |
| NCT00719199 | Study of FOLFIRI Plus Cetuximab Plus IMO-2055 in Patients With Colorectal Cancer | Phase 1 | terminated | Jul 21, 2008 | EMD Serono | Sponsor will discontinue further development of EMD 1201081 | Other (stated, no rule matched) |
| NCT01016860 | OSI-906 and Irinotecan in Patients With Advanced Cancer | Phase 1 | terminated | Nov 20, 2009 | University of Colorado, Denver | This study was discontinued due to a shown lack of efficacy in the investigational agent | Efficacy / futility |
| NCT00870961 | Vitamin D Supplement in Preventing Colon Cancer in African Americans With Colon Polyps | N/A | terminated | Mar 27, 2009 | Northwestern University | PI changed institutions and accrual was not completed. | Enrollment / accrual |
| NCT00145860 | Do Patients With Colorectal Cancer Understand That Their Family is at Risk? | — | terminated | Sep 5, 2005 | University of Chicago | not stated | Not stated |
| NCT00033306 | BMS-247550 in Treating Patients With Metastatic Colorectal Cancer | Phase 2 | terminated | Aug 6, 2003 | University of Alabama at Birmingham | not stated | Not stated |
| NCT00026468 | Exisulind in Preventing Polyps in Patients With Familial Adenomatous Polyposis | Phase 2 / Phase 3 | withdrawn | Jan 27, 2003 | University of Utah | Principle Investigator has left the University. | Investigator |
| NCT00003486 | Antineoplaston Therapy in Treating Patients With Colon Cancer | Phase 2 | withdrawn | Jan 27, 2003 | Burzynski Research Institute | not stated | Not stated |
| NCT00896467 | Psychological and Emotional Impact in Patients Undergoing Treatment For Metastatic Cancer… | — | terminated | May 11, 2009 | Centre Oscar Lambret | not stated | Not stated |
| NCT00932724 | CY-503 for the Treatment of Chemotherapy-refractory Metastatic Colorectal Cancer(CY503C2) | Phase 2 | terminated | Jul 3, 2009 | Cytavis Biopharma GmbH | The sponsor declared the early termination of the study due to poor recruitment of patients. | Enrollment / accrual |
| NCT00049608 | Gemcitabine Combined With Mistletoe in Treating Patients With Advanced Solid Tumors | Phase 1 | terminated | Jan 27, 2003 | National Center for Complementary and Integrative Health (NCCIH) | Principal investigator \[PI\] has left institution. | Investigator |
| NCT00908024 | Combination Study of BMS-754807 and Erbitux® in Subjects With Advanced or Metastatic… | Phase 1 / Phase 2 | terminated | May 25, 2009 | Bristol-Myers Squibb | not stated | Not stated |
| NCT01257035 | Predictive Value of 18F-FAZA in Rectum Cancer(FAZA) | — | terminated | Dec 9, 2010 | Vejle Hospital | The logistics of this trial (incl. supply of tracer) in connection with the patients' treatment… | Drug supply |
| NCT01872104 | Safety and Efficiency of Photodynamic Therapy for Rectal Cancer(PDT-R-01) | Phase 2 / Phase 3 | suspended | Jun 7, 2013 | li xiong | Modifying the clinnicaltrials | Other (stated, no rule matched) |
| NCT01293942 | IXO+A in mCRC With Liver-only Metastases | Phase 2 | withdrawn | Feb 11, 2011 | Ottawa Hospital Research Institute | not stated | Not stated |
| NCT00103272 | 17-N-Allylamino-17-Demethoxygeldanamycin and Bortezomib in Treating Patients With… | Phase 1 | terminated | Feb 8, 2005 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00006001 | SU5416 in Treating Patients With Metastatic or Locally Recurrent Colorectal Cancer | Phase 2 | terminated | May 26, 2004 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT01032291 | A Study to Assess the Efficacy and Safety of Lenalidomide in Combination With Cetuximab… | Phase 2 | terminated | Dec 15, 2009 | Celgene Corporation | A business decision not to continue with Phase 2b based on non-safety observations during proof of… | Safety / toxicity |
| NCT00012246 | Vaccine Therapy in Treating Patients With Cancer of the Gastrointestinal Tract | Phase 2 | terminated | Jan 27, 2003 | The University of Texas Medical Branch, Galveston | Administratively Terminated | Other (stated, no rule matched) |
| NCT00354185 | PXD101 and 17-N-Allylamino-17-Demethoxygeldanamycin in Treating Patients With Metastatic… | Phase 1 | terminated | Jul 20, 2006 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00268463 | Oxaliplatin and Capecitabine With or Without an Hepatic Arterial Infusion With… | Phase 3 | terminated | Dec 22, 2005 | NSABP Foundation Inc | The study was terminated due to low accrual. | Enrollment / accrual |
| NCT01189227 | Combination Chemotherapy Before or After Surgery in Treating Patients With Colorectal… | Phase 3 | terminated | Aug 26, 2010 | NSABP Foundation Inc | The study was terminated due to low accrual. | Enrollment / accrual |
| NCT00006015 | Combination Chemotherapy Plus Trastuzumab in Treating Patients With Advanced, Recurrent,… | Phase 2 | terminated | Jan 27, 2003 | National Cancer Institute (NCI) | lack of sufficient accrual | Enrollment / accrual |
| NCT00960427 | Studying Biomarkers in Tumor Tissue and Blood Samples From Patients Undergoing… | Phase 1 | withdrawn | Aug 17, 2009 | Barbara Ann Karmanos Cancer Institute | No surgeon available to perfrom gastroscopy | Other (stated, no rule matched) |
| NCT01466504 | Effect of Sorafenib or Regorafenib on P63 Expression and Keratinocyte Differentiation in… | — | terminated | Nov 8, 2011 | Dartmouth-Hitchcock Medical Center | Accrual did not meet expectations. Over nearly 2 years just 4 subjects were treated on study. The… | Enrollment / accrual |
| NCT00004193 | ISIS 2503 in Treating Patients With Metastatic and/or Locally Recurrent Colorectal Cancer | Phase 2 | terminated | Aug 5, 2004 | University of Alabama at Birmingham | not stated | Not stated |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Aug 29, 2014source: clinicaltrials