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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
881 stopped studies mapped to Malignant Intestinal Neoplasm and descendants · 90% state a reason
Over the 881 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT02317731 | Effect of Use of Straw on Tolerability and Quality of Split Dose 4l-PEG Preparation | N/A | terminated | Dec 16, 2014 | Yale University | PI relocated | Other (stated, no rule matched) |
| NCT01858662 | Study Comparing Pathological Responses Observed on Colorectal Cancer Metastases Resected… | Phase 2 | terminated | May 21, 2013 | Cliniques universitaires Saint-Luc- Université Catholique de Louvain | due to poor recrutment | Other (stated, no rule matched) |
| NCT00865527 | Pilot Study of Colon Cancer Screening Tests | N/A | terminated | Mar 19, 2009 | Hamilton Health Sciences Corporation | Lack of ongoing funding | Funding |
| NCT02720926 | Study of TKI 258 in Combination With Xeloda and Oxaliplatin in Advanced Colorectal and… | Phase 1 | terminated | Mar 28, 2016 | National Cancer Centre, Singapore | Unafavourable toxicity profile | Safety / toxicity |
| NCT00131586 | Cisplatin, Carboplatin, and Oxaliplatin Interactions With Plasma Proteins | — | terminated | Aug 19, 2005 | AHS Cancer Control Alberta | not stated | Not stated |
| NCT01157039 | A Trial of Glutamine to Prevent Oxaliplatin Neurotoxicity and a Pharmacokinetic Analysis… | Phase 2 | withdrawn | Jul 5, 2010 | AHS Cancer Control Alberta | abandoned | Other (stated, no rule matched) |
| NCT00305643 | Celecoxib in Preventing Hand/Foot Syndrome Caused By Capecitabine With Metastatic Breast… | Phase 3 | terminated | Mar 22, 2006 | M.D. Anderson Cancer Center | Terminated due to low accrual. No data analyzed. | Enrollment / accrual |
| NCT00271011 | A Study of Mitomycin C, Irinotecan, and Cetuximab | Phase 2 | terminated | Dec 29, 2005 | University of Michigan Rogel Cancer Center | The study was discontinued due to the death of a co-investigator and a second co-investigator… | Investigator |
| NCT01186705 | Clinical And Translational Study Of MK-2206 In Patients With Metastatic KRAS-Wild-Type,… | Phase 2 | terminated | Aug 23, 2010 | Memorial Sloan Kettering Cancer Center | Lack of accrual | Enrollment / accrual |
| NCT01816659 | An Open-Labeled Pilot Study of Biomarker Response Following Short-Term Exposure to… | Phase 1 | terminated | Mar 22, 2013 | M.D. Anderson Cancer Center | Slow Accrual | Enrollment / accrual |
| NCT00019747 | Surgery With or Without Thalidomide in Treating Patients With Recurrent or Metastatic… | Phase 2 | terminated | Jan 27, 2003 | National Institutes of Health Clinical Center (CC) | DSMB recommended closure of the protocol due to slow accrual. | Enrollment / accrual |
| NCT01856322 | Surgery Plus Sulindac or Surgery Alone for Advanced Colorectal Cancer | Phase 2 | terminated | May 17, 2013 | National Cancer Institute (NCI) | The trial was prematurely closed due to lack of accrual. | Enrollment / accrual |
| NCT01004159 | Cetuximab Plus Irinotecan in Colorectal Cancer Patients Who Progressed After Failure With… | Phase 2 | terminated | Oct 29, 2009 | Roswell Park Cancer Institute | former PI left institute | Investigator |
| NCT00717990 | Irinotecan, Capecitabine and Avastin for Metastatic Colorectal Cancer as Salvage Treatment | Phase 2 | terminated | Jul 18, 2008 | University Hospital of Crete | Poor Accrual | Enrollment / accrual |
| NCT00755118 | Lohp, 5-Fu/Lv and Bevacizumab, Alternative With Cpt-11, 5-Fu/Lv and Cetuximab In… | Phase 2 | terminated | Sep 18, 2008 | University Hospital of Crete | Due to poor Accrual | Enrollment / accrual |
| NCT00899132 | Studying a Tumor Marker for Testicular Cancer, Skin Cancer, Small Intestine Cancer, and… | — | terminated | May 12, 2009 | Case Comprehensive Cancer Center | Study due for continuing review | Other (stated, no rule matched) |
| NCT01501604 | BKM120 in Cancers With PIK3CA Activating Mutations | Phase 2 | withdrawn | Dec 29, 2011 | Massachusetts General Hospital | The study has been closed due to lack of accrual | Enrollment / accrual |
| NCT00250835 | Combination of Oxaliplatin, Capecitabine, and Celecoxib With Concurrent Radiation for… | Phase 2 | terminated | Nov 8, 2005 | New Mexico Cancer Research Alliance | Low accrual | Enrollment / accrual |
| NCT00244348 | Hepatic Artery Infusion With Oxaliplatin | Phase 1 / Phase 2 | withdrawn | Oct 26, 2005 | Medical College of Wisconsin | Investigator has left institution | Investigator |
| NCT02109224 | Ibrutinib in Treating Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma in Patients With… | Phase 1 | terminated | Apr 9, 2014 | National Cancer Institute (NCI) | Inadequate accrual rate | Enrollment / accrual |
| NCT01062919 | Local Anesthetic Wound Infusion and Functional Recovery After Colon Surgery | N/A | terminated | Feb 4, 2010 | Franco Carli | Low recruitment rate - \>70% of colorectal procedures are done laparoscopically | Enrollment / accrual |
| NCT01300858 | A Study of the Safety and Biological Activity of Intraperitoneal (IP) EGEN-001… | Phase 1 / Phase 2 | terminated | Feb 23, 2011 | EGEN, Inc. | Sites could not enroll patients. | Enrollment / accrual |
| NCT00099346 | MK0457 (an Aurora Kinase Inhibitor) Study in Patients With Advanced Colorectal Cancer and… | Phase 1 | terminated | Dec 13, 2004 | Merck Sharp & Dohme LLC | not stated | Not stated |
| NCT00396487 | Tailored Treatment in Metastatic Colorectal Cancer | Phase 3 | terminated | Nov 7, 2006 | Vejle Hospital | Only one patient included as per Feb. 4, 2008. | Other (stated, no rule matched) |
| NCT01375816 | Liposome-encapsulated Irinotecan Hydrochloride PEP02 or Irinotecan Hydrochloride,…(PEPCOL) | Phase 2 | terminated | Jun 17, 2011 | GERCOR - Multidisciplinary Oncology Cooperative Group | efficacy interim analysis as per protocol | Efficacy / futility |
| NCT02162641 | Study to Determine the Feasibility of Sentinel Node Biopsy in Patients With Anal Cancer(R-SeNSAR) | — | withdrawn | Jun 13, 2014 | The Christie NHS Foundation Trust | The study was terminated early as it failed to recruit. | Enrollment / accrual |
| NCT01238965 | Panobinostat and Fluorouracil Followed By Leucovorin Calcium in Treating Patients With… | Phase 1 | terminated | Nov 11, 2010 | University of Southern California | Adverse Events | Safety / toxicity |
| NCT00735241 | FOLFOX6 Plus Sir-Spheres Microspheres Plus Avastin in Patients With Nonresectable Liver…(FAST) | Phase 2 / Phase 3 | withdrawn | Aug 14, 2008 | Sirtex Medical | Withdrawn by the study sponsor. | Other (stated, no rule matched) |
| NCT01198535 | Phase I Study of Cetuximab With RO4929097 in Metastatic Colorectal Cancer | Phase 1 | terminated | Sep 10, 2010 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT01769911 | Genetically Modified Peripheral Blood Stem Cell Transplant in Treating Patients With… | N/A | withdrawn | Jan 17, 2013 | Fred Hutchinson Cancer Center | not stated | Not stated |
| NCT02235324 | Ziv-Aflibercept Followed by Ziv-Aflibercept, Fluorouracil, and Leucovorin Calcium in… | Phase 2 | withdrawn | Sep 9, 2014 | University of Southern California | Lack of funding | Funding |
| NCT00459901 | Study of the Antitumor Activity of Capecitabine in Combination With Erlotinib in Patients… | Phase 2 | terminated | Apr 13, 2007 | Peter Kozuch | Study halted by drug manufacturer | Drug supply |
| NCT01507740 | Profile of Soluble and Cellular Biomarkers and of Functional Imaging During… | — | terminated | Jan 11, 2012 | Medical University Innsbruck | Study was stopped 04.10.2014 prematurly after recruitment of HCC and RCC patients. NSCLC (2 of 10… | Enrollment / accrual |
| NCT00826800 | Neoadjuvant FOLFOX Plus Bevacizumab Chemotherapy in Patients With Locally Advanced Colon… | N/A | terminated | Jan 22, 2009 | Memorial Sloan Kettering Cancer Center | Lack of accrual | Enrollment / accrual |
| NCT01882972 | Strength for Health | N/A | withdrawn | Jun 21, 2013 | Loyola University | investigator left Loyola | Investigator |
| NCT01440127 | Impact of Pretreatment With Metformin on Colorectal Cancer Stem Cells (CCSC) and Related… | Phase 1 | terminated | Sep 26, 2011 | Tufts Medical Center | Unable to accrue all planned subjects in a timely fashion, but data collected will still be… | Enrollment / accrual |
| NCT00873600 | Outpatient Health Care Program for Older Patients Receiving Chemotherapy for Newly… | — | withdrawn | Apr 1, 2009 | Case Comprehensive Cancer Center | No accrual | Enrollment / accrual |
| NCT01706822 | Radial Reload Laparoscopic LAR Case Series | Phase 4 | terminated | Oct 15, 2012 | Medtronic - MITG | Slow recruitment | Enrollment / accrual |
| NCT00720512 | Second-Line Combination Chemotherapy With or Without Bevacizumab in Treating Patients…(BEBYP) | Phase 3 | terminated | Jul 22, 2008 | Gruppo Oncologico del Nord-Ovest | not stated | Not stated |
| NCT00575640 | Hydralazine as a Demethylating Agent in Rectal Cancer | Phase 1 / Phase 2 | withdrawn | Dec 18, 2007 | University of Arkansas | No enrollment | Enrollment / accrual |
| NCT01717014 | Radial Reload Open LAR Case Series | N/A | terminated | Oct 30, 2012 | Medtronic - MITG | not stated | Not stated |
| NCT00003843 | Irinotecan in Treating Patients With Colorectal Cancer | — | terminated | Jan 27, 2003 | California Cancer Consortium | Study terminated due to poor accrual | Enrollment / accrual |
| NCT01659424 | Phase II Trial of Preoperative High-dose-rate Endorectal Brachytherapy and FOLFOX…(HDRBT) | Phase 2 | withdrawn | Aug 7, 2012 | Beth Israel Medical Center | No participants were enrolled | Enrollment / accrual |
| NCT01631539 | Chemoembolisation With CPT11 Loaded DC Bead With Cetuximab and 5FU/LV in First Line in… | N/A | withdrawn | Jun 29, 2012 | Universitaire Ziekenhuizen KU Leuven | No patients enrolled | Enrollment / accrual |
| NCT01544452 | Total Preoperative MR Diagnostic Evaluation Versus Standard Diagnostic Evaluation in… | N/A | terminated | Mar 6, 2012 | Herlev Hospital | Lack of MR scanning capacity | Other (stated, no rule matched) |
| NCT01889680 | Safety and Effectiveness Study of Chemotherapy and Ziv-aflibercept to Treat Metastatic… | Phase 2 | withdrawn | Jun 28, 2013 | NSABP Foundation Inc | not stated | Not stated |
| NCT00823810 | Treatment Monitoring of Advanced Colorectal Cancer With 18F-FDG PET/CT(RESCORE) | N/A | terminated | Jan 16, 2009 | Turku University Hospital | Recruitment promlems | Enrollment / accrual |
| NCT00390364 | Everolimus in Treating Patients With Advanced or Metastatic Colorectal Cancer That Did… | Phase 2 | terminated | Oct 19, 2006 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | Withdrawn due to low accrual | Enrollment / accrual |
| NCT01149434 | Study of JI-101 in Patients With Advanced Low Grade Endocrine Tumors, Ovarian Cancers or… | Phase 1 / Phase 2 | terminated | Jun 23, 2010 | University of Utah | Lack of drug efficacy | Efficacy / futility |
| NCT00642746 | Erlotinib and Chemotherapy for 2nd Line Treatment (Tx) of Metastatic Colorectal Cancer… | Phase 2 | terminated | Mar 25, 2008 | OHSU Knight Cancer Institute | Terminated due to poor enrollment and grade 3 toxicities noted during an interim analysis. | Safety / toxicity |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Apr 18, 2016source: clinicaltrials