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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
881 stopped studies mapped to Malignant Intestinal Neoplasm and descendants · 90% state a reason
Over the 881 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT02407561 | Prospective Validation Study for the Proprietary Rectal and Anal Cancer Protein… | — | terminated | Apr 3, 2015 | Castle Biosciences Incorporated | Futility - unable to secure sites and samples for participation | Efficacy / futility |
| NCT01729923 | A Trial of Maintenance ADAPT Therapy With Capecitabine and Celecoxib in Patients With…(ADAPT) | Phase 2 | terminated | Nov 20, 2012 | University of Washington | Funding ended | Funding |
| NCT01012362 | Study of Pazopanib and Ixabepilone in Patients With Solid Tumors | Phase 1 | terminated | Nov 13, 2009 | Masonic Cancer Center, University of Minnesota | PI left institution. | Investigator |
| NCT02182466 | German Colon Capsule Registry(DEKOR) | — | terminated | Jul 8, 2014 | Johann Wolfgang Goethe University Hospital | not stated | Not stated |
| NCT00226941 | A Phase 1-2 Trial of Cetuximab in Combination With Oxaliplatin, Capecitabine, and… | Phase 1 / Phase 2 | terminated | Sep 27, 2005 | George Albert Fisher | The response rate observed in the phase 1 portion of the study did not merit further evaluation in… | Other (stated, no rule matched) |
| NCT01279681 | Combination Chemotherapy Plus Bevacizumab With or Without Oxaliplatin in Treating Older… | Phase 3 | terminated | Jan 19, 2011 | Alliance for Clinical Trials in Oncology | Slow accrual | Enrollment / accrual |
| NCT02057991 | Mindfulness-Based Exercise Video in Educating Hispanic/Latino Patients With Colorectal… | N/A | terminated | Feb 7, 2014 | University of Southern California | Insufficient Accrual | Enrollment / accrual |
| NCT00903396 | Palonosetron Hydrochloride in Preventing Nausea and Vomiting Caused by Radiation Therapy… | Phase 2 | terminated | May 18, 2009 | Alliance for Clinical Trials in Oncology | Slow accrual | Enrollment / accrual |
| NCT00625183 | Capecitabine, Oxaliplatin, Selenomethionine, and Radiation Therapy in Treating Patients… | Phase 2 | terminated | Feb 28, 2008 | Roswell Park Cancer Institute | Withdrawn due to poor/low accrual | Enrollment / accrual |
| NCT01606124 | Polyphenon E in Treating Patients With High-Risk of Colorectal Cancer | Phase 2 | terminated | May 25, 2012 | Mayo Clinic | pending expiration of the supply of study agent. | Drug supply |
| NCT02630420 | Cetuximab and Savolitinib Treatment of Ras Wild-Type Colorectal Cancer | Phase 1 | withdrawn | Dec 15, 2015 | Yale University | The study never officially funded and therefore never began. | Funding |
| NCT02774512 | Predictive Biomarkers of Biological Activity and Efficacy of Nilotinib on ZAK Target in…(ZAK-0) | Early Phase 1 | withdrawn | May 17, 2016 | Institut Bergonié | none participant has been enrolled and recruited during the first year after competent autority… | Enrollment / accrual |
| NCT03007771 | Magnetic Resonance-guided High-Intensity Focused Ultrasound (MR-HIFU) Used for Mild… | Phase 1 | withdrawn | Jan 2, 2017 | Washington University School of Medicine | Decision was made to not go forward with the study | Other (stated, no rule matched) |
| NCT00003522 | Antineoplaston Therapy in Treating Patients With Cancer of the Small Intestine | Phase 2 | terminated | Jan 27, 2003 | Burzynski Research Institute | slow accrual | Enrollment / accrual |
| NCT00003485 | Antineoplaston Therapy in Treating Patients With Metastatic or Unresectable Colon Cancer | Phase 2 | terminated | Jan 27, 2003 | Burzynski Research Institute | slow accrual | Enrollment / accrual |
| NCT02615574 | A Study of Type-1 Polarized Dendritic Cell (αDC1) Vaccine in Combination With… | Phase 2 | withdrawn | Nov 26, 2015 | Pawel Kalinski | Due to inadequate supply of drug | Drug supply |
| NCT02542436 | Avastin (Bevacizumab) in the Treatment of Metastatic Colorectal Cancer in Normal Clinical… | — | withdrawn | Sep 7, 2015 | Hoffmann-La Roche | not stated | Not stated |
| NCT02538627 | Phase 1 Combination Study of MM-151 With MM-121, MM-141, or Trametinib | Phase 1 | terminated | Sep 2, 2015 | Merrimack Pharmaceuticals | Sponsor decision | Sponsor / business decision |
| NCT02609451 | Closure of Protective Ileostomy 2 vs. 12 Weeks After TME(Closure2vs12) | N/A | terminated | Nov 20, 2015 | Kantonsspital Liestal | Evidence of bad outcome after interims analysis | Other (stated, no rule matched) |
| NCT03264274 | Trial of Aflibercept Monotherapy With DCE-US in Chemorefractory Metastatic Colorectal…(AUSCOR) | Phase 2 | withdrawn | Aug 29, 2017 | Barts & The London NHS Trust | Funding restrictions - study never opened to recruitment | Enrollment / accrual |
| NCT02345746 | Hepatic Arterial Infusion With FOLFOX Alone or in Combination With IV Chemotherapy in… | Phase 2 | withdrawn | Jan 26, 2015 | Western Regional Medical Center | patient population | Other (stated, no rule matched) |
| NCT01114256 | FNA Tumor Sampling for CD137 Modulation: A Pilot Study | — | terminated | May 3, 2010 | Stanford University | not stated | Not stated |
| NCT02079220 | A Phase II Study of Ziv-aflibercept in Combination With Capecitabine/Oxaliplatin (XELOX)… | Phase 2 | withdrawn | Mar 5, 2014 | James J Lee | Funding for the study was withdrawn, no participants were ever recruited. | Enrollment / accrual |
| NCT01419795 | Lenalidomide With or Without Rituximab in Treating Patients With Progressive or Relapsed… | Phase 2 | terminated | Aug 18, 2011 | Fred Hutchinson Cancer Center | Low accrual | Enrollment / accrual |
| NCT01847599 | Educational Intervention to Adherence of Patients Treated by Capecitabine +/- Lapatinib(ProMETheX) | N/A | terminated | May 7, 2013 | Centre Jean Perrin | interim analysis : discontinuation for efficacy of the intervention | Efficacy / futility |
| NCT00002664 | Monoclonal Antibody Therapy and Colony- Stimulating Factor in Treating Patients With… | Phase 2 | withdrawn | May 24, 2004 | James Ahlgren | No recruitment | Enrollment / accrual |
| NCT01309126 | Study of Imprime PGG® in Combination With Cetuximab in Subjects With Recurrent or…(PRIMUS) | Phase 3 | terminated | Mar 4, 2011 | HiberCell, Inc. | Due to enrollment challenges resulting from changing treatment patterns in the use of cetuximab,… | Enrollment / accrual |
| NCT01095523 | Prospective Randomized Trial Evaluating Mandatory Second Look Surgery With HIPEC and CRS… | Phase 2 | withdrawn | Mar 30, 2010 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT01176500 | A Pilot, Open-label Study of 18F-Fluciclatide PET/CT Imaging in the Evaluation of… | Phase 1 / Phase 2 | withdrawn | Aug 6, 2010 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT01386502 | CT-011 and p53 Genetic Vaccine for Advanced Solid Tumors | Phase 1 | withdrawn | Jul 1, 2011 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT01936961 | Study of Immunochemotherapy +/- Hypofractionated Radiation for Complete Response in Solid…(I-CREST) | N/A | withdrawn | Sep 6, 2013 | Western Regional Medical Center | No patients enrolled | Enrollment / accrual |
| NCT00408772 | Oxaliplatin, Capecitabine, and Bevacizumab Followed By Surgery and/or Radiofrequency… | Phase 2 | withdrawn | Dec 7, 2006 | University of California, Davis | Lack of accrual | Enrollment / accrual |
| NCT01940237 | A Pilot Trial of Interpersonal Psychotherapy for the Treatment of Depression in Patients… | N/A | terminated | Sep 12, 2013 | New York State Psychiatric Institute | Low recruitment | Enrollment / accrual |
| NCT00449163 | Combination Chemotherapy and Bevacizumab in Treating Patients With Stage IV Colorectal… | Phase 2 | terminated | Mar 19, 2007 | University of Miami | Study terminated by University of Miami Institutional Review Board | Other (stated, no rule matched) |
| NCT01326065 | Implementation of Laparoscopy-assisted Surgery for Colon Cancer | — | terminated | Mar 30, 2011 | Helse Stavanger HF | Study had to be terminated due to lack of funding | Funding |
| NCT01646554 | Efficacy of FOLFOX Versus FOLFOX Plus Aflibercept in K-ras Mutant Patients With…(BOS3) | Phase 2 / Phase 3 | withdrawn | Jul 20, 2012 | European Organisation for Research and Treatment of Cancer - EORTC | not stated | Not stated |
| NCT02277093 | Pacritinib to Inhibit JAK/STAT Signaling in Refractory Colorectal Cancer | Phase 2 | terminated | Oct 28, 2014 | Washington University School of Medicine | FDA issued a clinical hold as pacritinib had increased side effects | Other (stated, no rule matched) |
| NCT02060669 | Xeloda Maintenance Versus BSC in Metastatic Colorectal Cancer | Phase 3 | terminated | Feb 12, 2014 | Samsung Medical Center | others | Other (stated, no rule matched) |
| NCT02413853 | Combination Chemotherapy and Bevacizumab With or Without PRI-724 in Treating Patients…(PRIMIER) | Phase 2 | withdrawn | Apr 10, 2015 | University of Southern California | Study drug supply issues | Drug supply |
| NCT00126451 | A Clinical Trial of Oral Suberoylanilide Hydroxamic Acid (SAHA) in Patients With Relapsed… | Phase 2 | terminated | Aug 4, 2005 | Merck Sharp & Dohme LLC | not stated | Not stated |
| NCT00588900 | Irinotecan and Cediranib in Treating Patients With Metastatic Colorectal Cancer That Did… | Phase 2 | terminated | Jan 9, 2008 | Alliance for Clinical Trials in Oncology | not stated | Not stated |
| NCT01270438 | Combination Chemotherapy and Bevacizumab With or Without RO4929097 in Treating Patients… | Phase 2 | withdrawn | Jan 5, 2011 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT01229111 | Cediranib Maleate and Combination Chemotherapy in Treating Patients With Advanced Biliary… | Phase 2 | terminated | Oct 27, 2010 | National Cancer Institute (NCI) | Lack of Drug Supply | Drug supply |
| NCT00127036 | Trial for Microarray Analysis of Colon Cancer Outcome-A (MACCO-A) | Phase 2 | terminated | Aug 5, 2005 | H. Lee Moffitt Cancer Center and Research Institute | drug now on market | Other (stated, no rule matched) |
| NCT02857608 | A Prospective, Open-Label, Multi-center Comparison of Lymphoseek Identified Lymph Nodes… | Phase 2 | withdrawn | Aug 5, 2016 | Cardinal Health 414, LLC | not stated | Not stated |
| NCT02301338 | Improving Health of Patients With Colon Cancer Following Surgery: A Trial of SA-ICAN Via… | — | terminated | Nov 25, 2014 | Memorial Sloan Kettering Cancer Center | Lack of accrual | Enrollment / accrual |
| NCT01032590 | Internet-Based Weight-Loss Program for Colorectal Cancer Survivors | N/A | withdrawn | Dec 15, 2009 | Rutgers, The State University of New Jersey | Trial was only opened at RCINJ for analysis of data, no patient enrollment took place here. | Enrollment / accrual |
| NCT00361244 | SU011248 in Combination With Irinotecan and Cetuximab as a Second Line Regimen for Stage… | Phase 1 / Phase 2 | terminated | Aug 8, 2006 | Massachusetts General Hospital | Slow Accrual | Enrollment / accrual |
| NCT02423174 | Eval. of Safety and Effectiveness of the FMwand Ferromagnetic Surgical System During… | — | withdrawn | Apr 22, 2015 | Domain Surgical, Inc. | Funding | Funding |
| NCT00276861 | Gemcitabine and Oxaliplatin as Second-Line Therapy in Treating Patients With Metastatic… | Phase 2 | terminated | Jan 13, 2006 | University of Miami | Low Accrual | Enrollment / accrual |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 24 days agoSource updated Jan 25, 2018source: clinicaltrials