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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
826 stopped studies mapped to Malignant Female Reproductive System Neoplasm and descendants · 86% state a reason
Over the 826 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT01218490 | Pelvic and Aortic-cava Lymphadenectomy Randomized for Ovarian Cancer(CARACO) | Phase 3 | suspended | Oct 11, 2010 | Institut Cancerologie de l'Ouest | qualitative analysis of the study database | Other (stated, no rule matched) |
| NCT02943317 | Study to Investigate the Safety, Pharmacokinetics, Pharmacodynamics and Preliminary… | Phase 1 | terminated | Oct 24, 2016 | Verastem, Inc. | The study was terminated upon completion of escalation phase, prior to opening expansion cohorts | Other (stated, no rule matched) |
| NCT02575807 | Safety and Efficacy of CRS-207 With Epacadostat in Platinum Resistant Ovarian, Fallopian…(SEASCAPE) | Phase 1 / Phase 2 | terminated | Oct 15, 2015 | Aduro Biotech, Inc. | Study was stopped due to low enrollment and lack of clinical activity. | Enrollment / accrual |
| NCT02948101 | PD 0360324 and Cyclophosphamide in Treating Patients With Recurrent High-Grade Epithelial… | Phase 2 | withdrawn | Oct 28, 2016 | M.D. Anderson Cancer Center | PI's request | Other (stated, no rule matched) |
| NCT01685255 | A Phase 2 Study of the IDO Inhibitor Epacadostat Versus Tamoxifen for Subjects With… | Phase 2 | terminated | Sep 14, 2012 | Incyte Corporation | Study was terminated by the sponsor for lack of evidence of superiority and slow study accrual. | Enrollment / accrual |
| NCT02879058 | Intraoperative Ultrasound in Laparoscopic or Robotic Myomectomy Patients | N/A | terminated | Aug 25, 2016 | The Cleveland Clinic | Due to inadequate enrollment. | Enrollment / accrual |
| NCT02050009 | Metformin Hydrochloride, Carboplatin, and Paclitaxel in Treating Patients With Recurrent… | Phase 1 | withdrawn | Jan 30, 2014 | Fox Chase Cancer Center | study was never opened to accrual | Enrollment / accrual |
| NCT01083537 | Trial of Best Supportive Care and Either Cisplatin or Paclitaxel to Treat Patients With… | Phase 1 / Phase 2 | terminated | Mar 9, 2010 | University Health Network, Toronto | Slow accrual | Enrollment / accrual |
| NCT02411565 | Fermented Wheat Germ Extract in Women With Ovarian Cancer | Early Phase 1 | terminated | Apr 8, 2015 | H. Lee Moffitt Cancer Center and Research Institute | Drug manufacturing issues | Drug supply |
| NCT01251354 | Study of BN83495 in Post-menopausal Women With Endometrial Cancer Post-chemotherapy | Phase 2 | terminated | Dec 1, 2010 | Ipsen | The futility analysis of study NCT00910091 in patients with endometrial cancer shows that the… | Efficacy / futility |
| NCT02539719 | Study of SC-003 Alone and in Combination With ABBV-181 in Subjects With… | Phase 1 | terminated | Sep 3, 2015 | Stemcentrx | Strategic Considerations | Sponsor / business decision |
| NCT03206216 | Feasibility Study of New Method of Diagnostic and Prediction of Painful CIPN | N/A | terminated | Jul 2, 2017 | Stanford University | Business decision | Sponsor / business decision |
| NCT00257829 | Improving Tumor Oxygenation in Cervical Cancer | Phase 2 | withdrawn | Nov 23, 2005 | University of California, Irvine | This study was closed due to lack of funding. | Funding |
| NCT02530606 | Photoacoustic Imaging in Detecting Ovarian or Fallopian Tube Cancer | N/A | withdrawn | Aug 21, 2015 | Stanford University | Efficacy | Efficacy / futility |
| NCT00102622 | Intraperitoneal tgDCC-E1 and Intravenous Paclitaxel in Women With Platinum-Resistant… | Phase 1 | terminated | Feb 1, 2005 | M.D. Anderson Cancer Center | Phase I/II study that did not progress to Phase II | Other (stated, no rule matched) |
| NCT02470819 | Genomic and Proteomic Profiling Targets Influenced Treatment in Metastatic Breast Cancer | N/A | withdrawn | Jun 12, 2015 | Avera McKennan Hospital & University Health Center | Investigator elected to end the study | Investigator |
| NCT02669914 | MEDI4736 (Durvalumab) in Patients With Brain Metastasis From Epithelial-derived Tumors | Phase 2 | terminated | Feb 1, 2016 | Washington University School of Medicine | Low accrual, funding withdrawn by AstraZeneca, and change in clinical practice | Enrollment / accrual |
| NCT02868892 | A Study of Pemetrexed in Recurrent Cervical Adenocarcinomas | Phase 2 | terminated | Aug 16, 2016 | Western Regional Medical Center | departure of PI from institution and poor population for study participation | Other (stated, no rule matched) |
| NCT02589366 | Lymphoseek as Lymphoid Tissue Targeting Agent in Patients With Cancer of the Endometrium | Phase 1 | terminated | Oct 28, 2015 | University of California, San Diego | not stated | Not stated |
| NCT03220009 | Nivolumab or Expectant Observation Following Ipilimumab, Nivolumab, and Surgery in… | Phase 2 | withdrawn | Jul 18, 2017 | National Cancer Institute (NCI) | The study was never approved by CTEP neither was it ever activated | Other (stated, no rule matched) |
| NCT00003821 | Aminopterin in Treating Patients With Recurrent or Refractory Endometrial Cancer | Phase 2 | withdrawn | Aug 4, 2004 | Genzyme, a Sanofi Company | not stated | Not stated |
| NCT00005645 | ILX-295501 in Treating Patients With Stage III or Stage IV Ovarian Cancer That Has Not… | Phase 2 | withdrawn | May 26, 2004 | Genzyme, a Sanofi Company | not stated | Not stated |
| NCT02836028 | A Study Evaluating Talazoparib in Relapsed Ovarian, Fallopian Tube, and Peritoneal Cancer | Phase 2 | withdrawn | Jul 18, 2016 | Pfizer | not stated | Not stated |
| NCT00322881 | Carboplatin and Paclitaxel in Elderly Women With Newly Diagnosed Ovarian, Peritoneal, or… | Phase 2 | terminated | May 8, 2006 | Dana-Farber Cancer Institute | Early closure based on audit by study investigators after 3 patients died on study. | Other (stated, no rule matched) |
| NCT00910000 | Vorinostat, Carboplatin and Gemcitabine in Women With Recurrent, Platinum-Sensitive… | Phase 1 / Phase 2 | terminated | May 29, 2009 | Dana-Farber Cancer Institute | Terminated due to unacceptable toxicity | Safety / toxicity |
| NCT00039091 | Monoclonal Antibody Therapy in Treating Patients With Ovarian Epithelial Cancer,… | Phase 1 | terminated | Jan 27, 2003 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00730886 | ExAblate Treatment of Uterine Fibroids for Fertility Enhancement | N/A | terminated | Aug 8, 2008 | InSightec | not stated | Not stated |
| NCT00084890 | Docetaxel and Carboplatin in Treating Patients With Recurrent Stage IVB Squamous Cell… | Phase 1 | terminated | Jun 11, 2004 | Wake Forest University Health Sciences | slow accrual | Enrollment / accrual |
| NCT00856453 | Yoga in Relieving Fatigue in Patients Undergoing Chemotherapy for Ovarian Cancer | N/A | terminated | Mar 5, 2009 | Wake Forest University Health Sciences | slow accrual | Enrollment / accrual |
| NCT01197664 | Paricalcitol, Fluorouracil, and Radiation Therapy in Treating Patients With Rectal Cancer… | Phase 1 | terminated | Sep 9, 2010 | Wake Forest University Health Sciences | Study terminated due to funding issues | Funding |
| NCT01328067 | Study to Evaluate the Safety and Effectiveness of MRgFUS Compared With Myomectomy for the… | N/A | withdrawn | Apr 4, 2011 | InSightec | not stated | Not stated |
| NCT02878980 | An Exercise Intervention Trial to Reduce Symptoms & Improve Clinical Outcomes of… | N/A | withdrawn | Aug 25, 2016 | City of Hope Medical Center | Feasibility issues | Other (stated, no rule matched) |
| NCT02872519 | PET Imaging of Ovarian Carcinoma With 18F-FSPG | Early Phase 1 | withdrawn | Aug 19, 2016 | Vanderbilt-Ingram Cancer Center | No funding | Funding |
| NCT00866723 | Avastin in Patients With Epithelial Ovarian, Primary Peritoneal Serous or Fallopian Tube… | Phase 2 | terminated | Mar 20, 2009 | Beth Israel Deaconess Medical Center | Recruitment has been terminated prematurely because of poor enrollment. | Enrollment / accrual |
| NCT00899093 | YKL-40 in Serum Samples From Patients With Newly Diagnosed Stage III-IV Ovarian… | — | terminated | May 12, 2009 | Gynecologic Oncology Group | not stated | Not stated |
| NCT01275664 | Granisetron, Aprepitant, and Dexamethasone in Preventing Nausea and Vomiting in Patients… | N/A | terminated | Jan 12, 2011 | Gynecologic Oncology Group | Study terminated due to no patient population available | Other (stated, no rule matched) |
| NCT02818530 | Correlation Between Intraocular Pressure Measurement by Tomometer and Anterior Chamber… | N/A | terminated | Jun 29, 2016 | Tata Memorial Centre | Two patients developed corneal laceration and hence study re-reviewed by IEC and decided to… | Other (stated, no rule matched) |
| NCT02412124 | Peer-to-Peer Support Program in Improving Quality of Life Outcomes in Patients With… | N/A | terminated | Apr 8, 2015 | City of Hope Medical Center | Feasibility issues | Other (stated, no rule matched) |
| NCT02833506 | Sirolimus and Vaccine Therapy in Treating Patients With Stage II-IV Ovarian, Fallopian… | Phase 1 | withdrawn | Jul 14, 2016 | Roswell Park Cancer Institute | production of adjuvant to be used with vaccine was discontinued by sponsor | Other (stated, no rule matched) |
| NCT00005029 | Topotecan in Treating Patients With Recurrent Ovarian Epithelial or Primary Peritoneal… | Phase 2 | terminated | Jul 19, 2004 | Gynecologic Oncology Group | not stated | Not stated |
| NCT01773889 | A Trial of Intravenous Denileukin Diftitox Plus Subcutaneous Pegylated IFNα-2A in Stage… | Phase 2 | terminated | Jan 23, 2013 | The University of Texas Health Science Center at San Antonio | Lack of funding | Funding |
| NCT02708511 | Copper Cu 64-DOTA-B-Fab PET/CT in Imaging Patients With Ovarian and Breast Cancer | Phase 1 | terminated | Mar 15, 2016 | Sanjiv Sam Gambhir | not stated | Not stated |
| NCT02765698 | Efficacy of PET/MRI in Detecting Metastatic Disease in Endometrial Cancer | — | terminated | May 9, 2016 | Mayo Clinic | not stated | Not stated |
| NCT02110277 | Photoacoustic Imaging of the Ovary | N/A | terminated | Apr 10, 2014 | UConn Health | Dr Zhu, collaborator and the inventor of the photoacoustic system, is leaving the institution and… | Other (stated, no rule matched) |
| NCT00408070 | Bevacizumab Study With Carboplatin & Paclitaxel in Ovarian, Fallopian Tube or Primary… | Phase 2 | terminated | Dec 6, 2006 | UConn Health | Did not meet accrual goals. | Enrollment / accrual |
| NCT02110953 | Irinotecan-Eluting Beads in Treating Patients With Refractory Metastatic Colon or Rectal… | Phase 1 | terminated | Apr 10, 2014 | Fox Chase Cancer Center | IRB study closure by investigator due to low enrollment | Investigator |
| NCT00004261 | EF5 Prior to Surgery or Biopsy in Patients With Breast, Prostate, or Cervical Cancer or… | Phase 1 | terminated | Dec 11, 2003 | University Health Network, Toronto | Lack of patient accrual | Enrollment / accrual |
| NCT01936974 | (PGA) for Platinum-resistant/Refractory, Paclitaxel-Pretreated Recurrent Ovarian and…(PGA) | Phase 2 | terminated | Sep 6, 2013 | Western Regional Medical Center | PI Decision | Other (stated, no rule matched) |
| NCT00588263 | Anonymous Testing of Pathology Specimens for BRCA Mutations in Ashkenazi Jewish… | — | withdrawn | Jan 8, 2008 | Memorial Sloan Kettering Cancer Center | Data from MSK-IMPACT is sufficient for relevant analyses going forward | Other (stated, no rule matched) |
| NCT01934179 | Telomere Length in Predicting Toxicity in Older Patients With Stage III-IV Colorectal… | — | terminated | Sep 4, 2013 | Fox Chase Cancer Center | Low Accrual Rate | Enrollment / accrual |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated May 16, 2019source: clinicaltrials