PD 0360324 and Cyclophosphamide in Treating Patients With Recurrent High-Grade Epithelial Ovarian, Primary Peritoneal, or Fallopian Tube Cancer

Inclusion Criteria:

* Written informed consent
* Histology showing recurrent high grade epithelial ovarian, peritoneal, or fallopian tube cancer
* Platinum resistant or refractory disease as defined by progression of disease on a platinum-containing regimen or recurrence of disease within 180 days of previous platinum treatment
* Have measurable disease based on Response Evaluation Criteria in Solid Tumors (RECIST) 1.1; measurable disease is defined at least two lesions that can be accurately measured in at least one dimension (longest dimension to be recorded); each "target" lesion must be \> 20 mm when measured by palpitation or \>10 mm when measured by spiral computed tomography (CT), plain x-ray, magnetic resonance imaging (MRI), or positron emission tomography (PET)/CT; PET/CT will be acceptable at baseline if PET/CT was previously performed and available; imaging must be performed within -28 to -7 days of starting therapy; the target lesion must be distinct from other tumor areas selected for pre-treatment biopsies
* Subject must be willing to undergo protocol directed biopsies and blood draw for immune profiling
* Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1
* Life expectancy of \>= 4 months in the attending physician's estimation
* Estimated creatinine clearance \> 40 mL/min by the Cockcroft-Gault formula
* White blood cell (WBC) \>= 3.0 x 10\^3/ul
* Absolute neutrophil count (ANC) \>= 1.5 x 10\^9/L (\> 1500 per mm\^3)
* Platelet count \>= 100 x 10\^9/L (\> 100,000 per mm\^3)
* Hemoglobin \>= 9.0 g/dL
* Female subjects must either be of non-reproductive potential (i.e., post-menopausal by history: \>=60 years old and no menses for \> 1 year without an alternative medical cause; OR history of hysterectomy, OR history of bilateral tubal ligation, OR history of bilateral oophorectomy) or must have a negative serum pregnancy test upon study entry
* Subject must be willing and able to comply with the protocol for the duration of the study including undergoing treatment and scheduled visits and examinations including follow up
* Signed informed consent for protocol PA13-0291

Exclusion Criteria:

* Absence of a biopsiable lesion as determined by radiologist
* Chemotherapy, hormonal, or biologic treatment for ovarian, fallopian tube, or primary peritoneal cancer in the last 21 days
* History of another primary malignancy except for:

  * Malignancy treated with curative intent and with no known active disease \>=5 years before the first dose of study drug and of low potential risk for recurrence;
  * Adequately treated non-melanoma skin cancer or lentigo maligna without evidence of disease; or
  * Adequately treated carcinoma in situ without evidence of disease, e.g. cervical cancer in situ
* Current or prior use of immunosuppressive medication within 21 days before the first dose of PD 0360324, with the exceptions of intranasal and inhaled corticosteroids and systemic corticosteroids at physiological doses (defined as not exceeding 10 mg/day of prednisone, or an equivalent dose of over corticosteroid)
* Prior immunotherapy with immune checkpoint inhibitors
* Any unresolved toxicity (\> Common Terminology Criteria for Adverse Events \[CTCAE\] grade 1) from previous anti-cancer therapy with the exception of alopecia; subjects with irreversible toxicity that is not reasonably expected to be exacerbated by the investigational product may be included (e.g., hearing loss, peripheral neuropathy)
* Subjects with an active infection requiring antibiotics or at an increased risk of latent infection that may affect safe study participation
* Subjects with existing periorbital edema
* Subjects with aspartate aminotransferase (AST) or alanine transaminase (ALT) \>= 2 x upper limit of normal (ULN)
* Subjects with creatine kinase \> ULN
* Subjects with clinically significant active ischemic heart disease, cardiac muscle disease (including cardiomyopathy or congestive heart failure) or myodegenerative disorders that may affect safe study participation
* Receipt of live attenuated vaccination within 30 days prior to study entry or within 30 days prior to study entry
* History of allergic or anaphylactic reaction to any therapeutic or diagnostic monoclonal antibody (IgG protein) or molecules made of components of monoclonal antibodies (e.g., Enbrel which is the Fc portion of an antibody or Lucentis which is a Fab)
* Pregnant or breastfeeding women or women of child-bearing potential who are not willing to use two highly effective methods of contraception (i.e., a hormonal contraceptive, intrauterine device, diaphragm with spermicide, condom with spermicide, or abstinence)
* Uncontrolled intercurrent illness including, but not limited to, bowel obstruction, uncontrolled hypertension, unstable angina pectoris, cardiac arrhythmia, active peptic ulcer disease or gastritis, active bleeding diatheses including any subject known to have evidence of acute or chronic hepatitis B, hepatitis C or human immunodeficiency virus (HIV), tuberculosis, or psychiatric illness/social situations that would limit compliance with study requirements or compromise the ability of the subject to give written informed consent, or undergo study procedures
* History of leptomeningeal carcinomatosis or brain metastasis