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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
196 stopped studies mapped to Malignant Esophageal Neoplasm and descendants · 93% state a reason
Over the 196 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT02272699 | Neoadjuvant Treatment of Nimotuzumab With Chemotherapy or Radiotherapy in Resectable… | Phase 2 / Phase 3 | withdrawn | Oct 23, 2014 | Peking University | Because there are questions about adjuvant radiotherapy in this study, the clinical trial is under… | Other (stated, no rule matched) |
| NCT04086901 | Dose Escalated Adaptive RadioTherapy in Definitive Chemo-radiotherapy for Esophageal…(DART) | N/A | terminated | Sep 12, 2019 | University of Aarhus | New data show no effect of dose escalation and also poor recruitment | Enrollment / accrual |
| NCT02864355 | Does Perioperative Goal Directed Therapy Using Flotrac Improve Outcomes in Esophagectomy… | N/A | terminated | Aug 12, 2016 | Medical University of South Carolina | Minimally invasive surgical methods have ceased enrollment | Enrollment / accrual |
| NCT04084158 | A Study of Toripalimab Combined With Concurrent Chemoradiotherapy for Locally Advanced… | Phase 2 | suspended | Sep 10, 2019 | Zhejiang Cancer Hospital | combination arm delevelped significant poor prognosis | Other (stated, no rule matched) |
| NCT00064259 | A Phase I/II Study of Oblimersen Plus Cisplatin and Fluorouracil in Gastric & Esophageal… | Phase 1 / Phase 2 | terminated | Jul 9, 2003 | National Cancer Institute (NCI) | Discontinued development of G3139 (oblimersen) | Other (stated, no rule matched) |
| NCT02757391 | CD8+ T Cell Therapy and Pembrolizumab in Treating Patients With Metastatic… | Phase 1 | terminated | May 2, 2016 | M.D. Anderson Cancer Center | Study halted prematurely and will not resume; participants are no longer being examined or… | Other (stated, no rule matched) |
| NCT02297607 | Routine Post-Operative Supplemental Nutrition | N/A | terminated | Nov 21, 2014 | University of Michigan | Poor accrual. Patients were reluctant to agree if they would need tube feeding for a month. | Enrollment / accrual |
| NCT00006472 | Combination Chemotherapy Plus Radiation Therapy Followed By Surgery in Treating Patients… | Phase 2 | terminated | Feb 26, 2004 | Medstar Health Research Institute | not stated | Not stated |
| NCT01249443 | Paclitaxel and Carboplatin in Treating Patients With Metastatic or Recurrent Solid Tumors… | Phase 1 | terminated | Nov 29, 2010 | AIDS Malignancy Consortium | Inadequate accrual rate | Enrollment / accrual |
| NCT02017600 | A Phase II Trial of Induction Chemotherapy With ND-420, Cisplatin and Fluorouracil… | Phase 2 | terminated | Dec 23, 2013 | Nang Kuang Pharmaceutical Co., Ltd. | not stated | Not stated |
| NCT03206125 | NCI UNC Project ESCC | — | terminated | Jul 2, 2017 | National Cancer Institute (NCI) | determined not to be human subjects research | Other (stated, no rule matched) |
| NCT00539617 | Chemotherapy & Erlotinib in Treating Patients w/ Esophageal or Gastroesophageal Cancer… | Phase 2 | terminated | Oct 4, 2007 | University of California, San Francisco | For slow accrual | Enrollment / accrual |
| NCT01143545 | Pilot Study of Allogeneic Tumor Cell Vaccine With Metronomic Oral Cyclophosphamide and… | Phase 1 | terminated | Jun 14, 2010 | National Cancer Institute (NCI) | Closed accrual due to unpromising results and the opening of study 14C0053 targeting the same… | Enrollment / accrual |
| NCT03818997 | Combination of Targeted and Immunotherapy for Advanced Biliary Tract and Esophagogastric…(DYNAMIC) | Phase 2 | withdrawn | Jan 28, 2019 | European Organisation for Research and Treatment of Cancer - EORTC | Company decision | Sponsor / business decision |
| NCT03110939 | Thoracic Surgery Combined With Intrathoracic Hyperthermic Perfusion for Advanced Lung… | N/A | withdrawn | Apr 12, 2017 | Henan Cancer Hospital | The principal investigator Dr.YinLi is working in other Hospital | Investigator |
| NCT01624090 | Mithramycin for Lung, Esophagus, and Other Chest Cancers | Phase 2 | terminated | Jun 20, 2012 | National Cancer Institute (NCI) | Study closed due to low accrual. | Enrollment / accrual |
| NCT00585117 | Pilot Study of (61)CuATSM-PET Imaging in Cancer Patients | N/A | terminated | Jan 3, 2008 | University of Wisconsin, Madison | change in imaging priorities | Other (stated, no rule matched) |
| NCT01258868 | Tumor Cell Vaccines With ISCOMATRIX Adjuvant and Celecoxib in Patients Undergoing… | Phase 1 | terminated | Dec 13, 2010 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT02318901 | Pembrolizumab and Monoclonal Antibody Therapy in Advanced Cancer(PembroMab) | Phase 1 / Phase 2 | terminated | Dec 17, 2014 | Western Regional Medical Center | PI no longer at sight. Results not collected | Other (stated, no rule matched) |
| NCT03211780 | Use of Intra-Operative Shear Wave Ultrasound Vibrometry for Characterization of… | N/A | terminated | Jul 7, 2017 | Mayo Clinic | Terminated due to the inability to enroll and carry out study intervention. | Enrollment / accrual |
| NCT02062632 | Doxepin Hydrochloride in Treating Esophageal Pain in Patients With Thoracic Cancer… | Phase 2 | terminated | Feb 14, 2014 | Mayo Clinic | Poor accrual | Enrollment / accrual |
| NCT02457299 | Esophagectomy With or Without Prior Ischemic Gastric Preconditioning | N/A | terminated | May 29, 2015 | Endeavor Health | Standard of care was modified at the primary institution | Other (stated, no rule matched) |
| NCT01498757 | Genome-wide Association Study | — | withdrawn | Dec 23, 2011 | Samsung Medical Center | Registration poor | Other (stated, no rule matched) |
| NCT01248299 | Benefit of Chemotherapy Over Best Supportive Care in Metastatic and Squamous Cell-type…(E-DIS) | Phase 2 | terminated | Nov 25, 2010 | Centre Oscar Lambret | not stated | Not stated |
| NCT03122548 | Safety and Efficacy of CRS-207 With Pembrolizumab in Gastric, Gastroesophageal Junction… | Phase 2 | terminated | Apr 21, 2017 | Aduro Biotech, Inc. | Low enrollment and lack of clinical activity in other CRS-207 studies. | Enrollment / accrual |
| NCT00372450 | Plastic Stents Compared With Metal Stents in Treating Patients With Malignant Dysphagia… | N/A | withdrawn | Sep 7, 2006 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | low accrual | Enrollment / accrual |
| NCT02547142 | Early Integration of Palliative Care in Esophageal Cancer Patients | N/A | terminated | Sep 11, 2015 | McMaster University | Study futility with regards to recruitment | Efficacy / futility |
| NCT01372202 | CHFR Methylation Status Esophageal Cancer Study(J10130) | Phase 2 | terminated | Jun 13, 2011 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | Study stopped due to early stopping rule | Other (stated, no rule matched) |
| NCT02221245 | Wnt, Notch and Hedgehog Activity in Chemo-Naive Tumors Collected During Staging of… | — | terminated | Aug 20, 2014 | University of Miami | Study terminated due to low accrual. | Enrollment / accrual |
| NCT03234842 | Dose Escalated Proton Beam Therapy or Photon Therapy for Esophageal Cancer(ES01) | Phase 2 | withdrawn | Jul 31, 2017 | University of Florida | non-accrual | Enrollment / accrual |
| NCT00493025 | Paclitaxel, Cisplatin, Gefitinib, and Radiation Therapy Followed by Surgery and Gefitinib… | Phase 2 | terminated | Jun 27, 2007 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | Closed due to early stopping rule-Low accrual | Enrollment / accrual |
| NCT01446874 | Prevention of Post-operative Pneumonia (POPP)(POPP) | Phase 2 / Phase 3 | terminated | Oct 5, 2011 | Washington University School of Medicine | Slow patient accrual and plans to perform multi-center study | Enrollment / accrual |
| NCT03223662 | Metabolomic and BH3 Profiling of Esophageal Cancers: Identification of Novel Assessment… | Phase 2 | terminated | Jul 21, 2017 | National Cancer Institute (NCI) | Principal Investigator left the NIH. | Investigator |
| NCT02234180 | Regorafenib in Treating Patients With Locally Advanced Cancer of the Esophagus or… | Phase 2 | terminated | Sep 9, 2014 | Academic and Community Cancer Research United | not stated | Not stated |
| NCT03220009 | Nivolumab or Expectant Observation Following Ipilimumab, Nivolumab, and Surgery in… | Phase 2 | withdrawn | Jul 18, 2017 | National Cancer Institute (NCI) | The study was never approved by CTEP neither was it ever activated | Other (stated, no rule matched) |
| NCT01471249 | Quality of Life and Dysphagia Following Palliative Stenting in Esophageal Cancer | — | terminated | Nov 15, 2011 | Centre hospitalier de l'Université de Montréal (CHUM) | Insuffisant personnel | Other (stated, no rule matched) |
| NCT02358863 | Molecularly Tailored Therapy for Patients With Metastatic Cancer of the Esophagus and…(mEGA) | N/A | terminated | Feb 9, 2015 | Georgetown University | Issues with recruitment. | Enrollment / accrual |
| NCT01608464 | Pre-op Chemo-RT w/CDDP/5FU vs Chemo w/ Docetaxel/Irinotecan in PET Non Responder… | Phase 2 | terminated | May 31, 2012 | King Faisal Specialist Hospital & Research Center | poor accrual | Enrollment / accrual |
| NCT01738633 | Quality of Life After Esophagectomy for Cancer - Step 2 | N/A | terminated | Nov 30, 2012 | University of Padova | Surgical Unit closed and moved. | Other (stated, no rule matched) |
| NCT02638909 | Study of Oral Ceritinib in Patients With ALK and ROS1 Activated Gastrointestinal… | Phase 2 | terminated | Dec 23, 2015 | Criterium, Inc. | Lack of Enrollment | Enrollment / accrual |
| NCT00827671 | Study of Combination of Cetuximab and Radiotherapy Added to the Standard Treatment for…(TRACC) | Phase 2 | terminated | Jan 23, 2009 | P.O. Witteveen | Experimental treatment not feasible due to high rate of drop out | Other (stated, no rule matched) |
| NCT01627379 | Cisplatin and 5-FU +/- Panitumumab for Patients With Nonresectable,Advanced or Metastatic…(POWER) | Phase 3 | terminated | Jun 25, 2012 | AIO-Studien-gGmbH | Sponsor decision due to recommendation of the IDMC. | Sponsor / business decision |
| NCT02392377 | Molecular Phenotyping in Predicting Response in Patients With Stage IB-III Esophageal… | Phase 2 | terminated | Mar 19, 2015 | Case Comprehensive Cancer Center | Slow accrual | Enrollment / accrual |
| NCT00256269 | Oxaliplatin and Irinotecan in Recurrent or Metastatic Esophageal and Gastroesophageal… | Phase 2 | terminated | Nov 21, 2005 | University of California, Irvine | Study was terminated by funding entity | Funding |
| NCT00848783 | Irinotecan/Cisplatin, Potentially Curative Surgery With or Without Floxuridine, Followed… | Phase 2 | terminated | Feb 20, 2009 | NYU Langone Health | Due to slow accrual | Enrollment / accrual |
| NCT03307941 | Assessment of Metabolic & Path Response w/ RCT & ImT Before Surgery in Locally Advanced…(ARTEMIS-Eso) | Phase 1 / Phase 2 | withdrawn | Oct 12, 2017 | Jules Bordet Institute | Suspended collaboration with the company providing the study drug | Sponsor / business decision |
| NCT02157363 | POsitioning for Esophageal Cancer Resection(POETRI) | N/A | terminated | Jun 6, 2014 | Technische Universität Dresden | poor recruitment due to change of surgical technique | Enrollment / accrual |
| NCT01065818 | Early Prediction of Pathology Response of Chemoradiotherapy With FLT PET | N/A | terminated | Feb 9, 2010 | Columbia University | Lack of funding | Funding |
| NCT01740375 | Role of Esophagectomy in Complete Responders to CCRT(ESOPRESSO) | Phase 3 | terminated | Dec 4, 2012 | Asan Medical Center | slow recruitment | Enrollment / accrual |
| NCT01738620 | Quality of Life After Esophagectomy for Cancer - Step 1 | N/A | terminated | Nov 30, 2012 | University of Padova | In October 2015 ICU's setting completely changed from an open concept 8-beds unit to a single bed… | Other (stated, no rule matched) |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Mar 18, 2021source: clinicaltrials