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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
2,226 stopped studies mapped to Malignant Digestive System Neoplasm and descendants · 91% state a reason
Over the 2,226 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT00564720 | Gemcitabine Plus Erlotinib Versus Erlotinib Plus Gemcitabine Plus Oxaliplatin, in… | Phase 2 | terminated | Nov 28, 2007 | Hellenic Oncology Research Group | Due to poor accrual of the study | Enrollment / accrual |
| NCT00681876 | Phase II Study of Avastin + Erbitux + Irinotecan as 2nd Line Treatment of Colorectal… | Phase 2 | terminated | May 21, 2008 | Hellenic Oncology Research Group | Due to poor accrual | Enrollment / accrual |
| NCT00755534 | Irinotecan/Cetuximab Followed by XELOX/Cetuximab vs the Reverse Sequence in Metastatic CRC | Phase 2 | terminated | Sep 19, 2008 | Hellenic Oncology Research Group | Due to poor accrual | Enrollment / accrual |
| NCT00003147 | Gene Therapy in Treating Patients With Cancer of The Liver | Phase 1 | terminated | Aug 24, 2004 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00002796 | Phase I-II Study of Fluorouracil in Combination With Phenylbutyrate in Advanced… | Phase 1 / Phase 2 | terminated | Jan 27, 2003 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00087334 | Capecitabine, Oxaliplatin, and Gefitinib in Treating Patients With Metastatic Colorectal… | Phase 1 / Phase 2 | terminated | Jul 12, 2004 | Roswell Park Cancer Institute | Withdrawn due to poor/low accrual | Enrollment / accrual |
| NCT00524069 | Gemcitabine, Capecitabine, and Bevacizumab in Treating Patients With Pancreatic Cancer… | N/A | withdrawn | Sep 3, 2007 | Roswell Park Cancer Institute | Withdrawn due to no accrual | Enrollment / accrual |
| NCT00070122 | Combination Chemotherapy and Bevacizumab in Treating Patients With Locally Advanced,… | Phase 3 | terminated | Oct 7, 2003 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00070265 | Neoadjuvant and Adjuvant Capecitabine and Oxaliplatin in Treating Patients With… | Phase 2 | terminated | Oct 7, 2003 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00047333 | Erlotinib in Treating Patients With Liver Cancer That Cannot be Surgically Removed | Phase 2 | terminated | Jan 27, 2003 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00061958 | Arsenic Trioxide in Treating Patients With Advanced Cancer of the Esophagus or… | Phase 2 | terminated | Jun 6, 2003 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT01619696 | Prospective Pilot Study of Multimodal Radiological Evaluation Feasibility During… | Phase 2 | terminated | Jun 14, 2012 | University Hospital, Toulouse | Insufficient recruitment | Enrollment / accrual |
| NCT00052585 | Gefitinib and Combination Chemotherapy in Treating Patients With Advanced or Recurrent… | Phase 2 | terminated | Jan 27, 2003 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00087191 | EF5 and Motexafin Lutetium in Detecting Tumor Cells in Patients With Abdominal or… | N/A | terminated | Jul 12, 2004 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00699374 | Study Of Sunitinib Malate Versus Sorafenib In Patients With Inoperable Liver Cancer | Phase 3 | terminated | Jun 18, 2008 | Pfizer | See termination reason in detailed description. | Other (stated, no rule matched) |
| NCT01611506 | Combination Chemotherapy, Cetuximab and Radiation for Patients With Localized Gastric… | Phase 1 / Phase 2 | terminated | Jun 5, 2012 | Dr Anna Dorothea Wagner | Outcome of EXPAND study (no benefit from adding cetuximab to the first-line chemotherapy in… | Other (stated, no rule matched) |
| NCT01219543 | A Phase I Study of AZD1480 in Patients With Advanced Solid Malignancies and Advanced… | Phase 1 | terminated | Oct 13, 2010 | AstraZeneca | Compound development discontinued | Other (stated, no rule matched) |
| NCT00087256 | Celecoxib in Preventing Polyps in Patients Who Have Undergone Surgery for Stage I Colon… | Phase 3 | terminated | Jul 12, 2004 | NSABP Foundation Inc | For scientific, logistic, and administrative reasons. | Other (stated, no rule matched) |
| NCT00118105 | S0408: Capecitabine, Oxaliplatin, and Bevacizumab in Pts Undergoing Surgery for Liver… | Phase 2 | withdrawn | Jul 11, 2005 | SWOG Cancer Research Network | Budget Constraints | Funding |
| NCT00766220 | Yttrium Microspheres With Cetuximab Plus Irinotecan for Patients With Advanced Colorectal… | Phase 2 | withdrawn | Oct 3, 2008 | M.D. Anderson Cancer Center | Slow Accrual and withdrawn/exclusion of 2 participants. | Enrollment / accrual |
| NCT00288444 | Interaction of Docetaxel and Lonafarnib in Patients With Advanced Cancer | Phase 1 | terminated | Feb 8, 2006 | Emory University | not stated | Not stated |
| NCT01071434 | Feasibility of Using Real-time Cine-MRI for Treating Moving & Deforming Tumors | — | terminated | Feb 19, 2010 | Stanford University | PI left | Investigator |
| NCT00387348 | Escitalopram in Treating Depression in Patients With Advanced Lung or Gastrointestinal… | Phase 3 | terminated | Oct 13, 2006 | Massachusetts General Hospital | DSMB stopped study because placebo arm had more adverse events | Safety / toxicity |
| NCT00966251 | Safety and Tolerability Study of the Monoclonal Antibody CT-011 in Patients With… | Phase 1 / Phase 2 | terminated | Aug 26, 2009 | CureTech Ltd | The study was stopped because of slow accrual | Enrollment / accrual |
| NCT00093548 | Vaccine Therapy in Treating Patients With Stage II, Stage IIIA, Stage IIIB, or Stage IVA… | Phase 1 / Phase 2 | withdrawn | Oct 8, 2004 | Jonsson Comprehensive Cancer Center | not stated | Not stated |
| NCT00004099 | Surgery With or Without Combination Chemotherapy in Treating Patients With Stomach Cancer | Phase 3 | terminated | Jan 27, 2003 | European Organisation for Research and Treatment of Cancer - EORTC | low accrual | Enrollment / accrual |
| NCT00043004 | Chemotherapy and Bevacizumab With or Without Radiofrequency Ablation in Treating… | Phase 2 | terminated | Jan 27, 2003 | European Organisation for Research and Treatment of Cancer - EORTC | low accrual | Enrollment / accrual |
| NCT00068744 | Radiation Therapy, Mitomycin, and Either Fluorouracil or Cisplatin in Treating Patients… | Phase 2 / Phase 3 | terminated | Sep 11, 2003 | European Organisation for Research and Treatment of Cancer - EORTC | low accrual | Enrollment / accrual |
| NCT00027521 | Electroporation Therapy With Bleomycin in Treating Patients With Pancreatic Cancer | Phase 1 | withdrawn | Nov 21, 2003 | Ichor Medical Systems Incorporated | Program terminated | Other (stated, no rule matched) |
| NCT00293436 | Celecoxib and Erlotinib in Treating Patients With Liver Cancer | Phase 1 / Phase 2 | withdrawn | Feb 17, 2006 | University of California, San Francisco | not stated | Not stated |
| NCT00410774 | Gemcitabine and Bevacizumab in Treating Patients With Pancreatic Cancer That Has Been… | Phase 1 / Phase 2 | terminated | Dec 13, 2006 | University of California, San Francisco | low accrual-no data available | Enrollment / accrual |
| NCT00025532 | Radiolabeled Monoclonal Antibody Therapy in Treating Patients With Gastrointestinal Cancer | Phase 1 | withdrawn | Nov 21, 2003 | University of California, San Francisco | not stated | Not stated |
| NCT01009593 | Efficacy and Tolerability of ABT-869 Versus Sorafenib in Advanced Hepatocellular… | Phase 3 | terminated | Nov 6, 2009 | Abbott | See termination reason in detailed description | Other (stated, no rule matched) |
| NCT00080002 | Efficacy of Pegamotecan (PEG-Camptothecin) in Localized or Metastatic Cancer of the… | Phase 2 | terminated | Mar 23, 2004 | Enzon Pharmaceuticals, Inc. | not stated | Not stated |
| NCT00855634 | Resection in Pancreatic Cancer With Minimal Metastatic Disease or Venous Infiltration…(PaMeViTUM) | N/A | terminated | Mar 4, 2009 | Technical University of Munich | Protocol planned interim analysis after two years showed very low recruitment in cohort 1 and low… | Efficacy / futility |
| NCT00469963 | Internal Radiation Therapy in Treating Patients With Primary Liver Cancer That Cannot Be… | N/A | terminated | May 7, 2007 | Vanderbilt-Ingram Cancer Center | slow accrual | Enrollment / accrual |
| NCT00838968 | The Efficiency of Postoperative Interferon-alpha Treatment in p48 Positive Patients With… | N/A | withdrawn | Feb 9, 2009 | Fudan University | we have found another marker (microRNA26) which is more sensitive to evaluate the effect of… | Other (stated, no rule matched) |
| NCT00335959 | S0425 Oxaliplatin, Capecitabine, and RT in Treating Patients W/Stomach Cancer That Can Be… | Phase 2 | terminated | Jun 12, 2006 | SWOG Cancer Research Network | Closed due to slow accrual | Enrollment / accrual |
| NCT00713687 | Gemcitabine/Oxaliplatin and Photodynamic Therapy in Cholangiocarcinoma(GemOx-PDT) | Phase 2 | withdrawn | Jul 11, 2008 | Technical University of Munich | recruiting failed | Enrollment / accrual |
| NCT00828620 | Positron Emission Tomography - Computed Tomography (PET-CT) Cetuximab Project | — | terminated | Jan 26, 2009 | Universitaire Ziekenhuizen KU Leuven | Lack of recruitment | Enrollment / accrual |
| NCT01238653 | Feasibility of a Minimally Invasive Image-Guided Surgery System for Hepatic Procedures | — | terminated | Nov 10, 2010 | Pathfinder Therapeutics | Slow enrollment with limited population for study parameters. | Enrollment / accrual |
| NCT01270893 | Tasigna Neoadjuvant Gastrointestinal Stromal Tumor (GIST) | Phase 2 | withdrawn | Jan 5, 2011 | M.D. Anderson Cancer Center | No particapnt recruitment. | Enrollment / accrual |
| NCT00426829 | Proton Therapy and Bevacizumab for Primary Liver Tumors | Phase 1 | terminated | Jan 25, 2007 | M.D. Anderson Cancer Center | Low Accural | Other (stated, no rule matched) |
| NCT00062023 | Comparison of Sulindac, Aspirin, and Ursodiol in Preventing Colorectal Cancer | Phase 2 | terminated | Jun 6, 2003 | M.D. Anderson Cancer Center | Study closed by the NCI. | Other (stated, no rule matched) |
| NCT00030511 | Radiation Therapy and Fluorouracil Before Surgery in Treating Patients With Primary or… | Phase 2 | terminated | Jan 27, 2003 | European Organisation for Research and Treatment of Cancer - EORTC | low accrual | Enrollment / accrual |
| NCT00368329 | Phase I Dose Escalation of Stereotactic Radiosurgical Boost for Locally Advanced… | Phase 1 | terminated | Aug 24, 2006 | Stanford University | low accrual | Enrollment / accrual |
| NCT01094600 | Comparison of Secretin-enhanced Magnetic Resonance Cholangiopancreatography (S-MRCP) to… | N/A | withdrawn | Mar 29, 2010 | Columbia University | not stated | Not stated |
| NCT00562666 | Immunotherapy of Hepatocellular Carcinoma With Gamma Delta T Cells(ICAR) | Phase 1 | terminated | Nov 22, 2007 | Rennes University Hospital | not stated | Not stated |
| NCT00004897 | Combination Chemotherapy and Interferon Alfa Followed by Surgery and/or Radiation Therapy… | Phase 2 | terminated | Jul 26, 2004 | Northwestern University | Institutional Review Board requested termination - all patients deceased and no new accrual. | Enrollment / accrual |
| NCT01327521 | Transarterial Chemoembolization vs CyberKnife for Recurrent Hepatocellular Carcinoma | Phase 3 | withdrawn | Apr 1, 2011 | Albert Koong | Accrual below target levels | Enrollment / accrual |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Feb 15, 2013source: clinicaltrials